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  • Articles: DFG German National Licenses  (5)
  • 1995-1999  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Neuronal correlates of encoding and retrieval in episodic memory during a paired-word association learning task: a functional magnetic resonance imaging study (1999)
    Springer
    Experimental brain research 128 (1999), S. 332-342 
    Details
    ISSN: 1432-1106
    Keywords: Key words Episodic memory ; Paired word association ; fMRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The investigation of memory function using functional magnetic resonance imaging (fMRI) is an expanding field of research. The aim of this study was to demonstrate brain-activity patterns related to a word-pair association task employing a whole-brain EPI sequence. Six right-handed, healthy male volunteers (mean age: 27.5 years) took part in the study. fMRI was performed at a field strength of 1.5 Tesla with 26–32 slices parallel to the AC-PC line, depending on individual brain size. Distributed brain regions were activated in episodic encoding and retrieval with similarities, but also (distinct) differences in activation patterns. Bilateral prefrontal cortical areas were involved when comparing encoding as well as retrieval to the reference condition (nonsense words). Furthermore, activation was observed in cerebellar areas during encoding, and activation in bilateral parietal areas (precuneus and inferior parietal cortex) was differentially more pronounced during retrieval. The activation of left dorsomedial thalamus during retrieval of high imagery-content word-pair associates may point to the role of this structure in episodic retrieval. The direct cognitive subtraction of encoding minus retrieval yielded a differentially larger left prefrontal activation. There was a differentially higher right prefrontal activation during retrieval than during encoding, underlining the proposed right/left asymmetry for episodic memory processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050853
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Network analysis in episodic encoding and retrieval of word-pair associates: a PET study (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The involvement of distributed brain regions in declarative memory has been hypothesized based on studies with verbal memory tasks. To characterize episodic declarative memory function further, 14 right-handed volunteers performed a visual verbal learning task using paired word associates. The volunteers underwent positron emission tomography. 15O-butanol was used as a tracer of regional cerebral blood flow (rCBF). Inter-regional functional interactions were assessed based on within-task, across-subject inter-regional rCBF correlations. Anatomical connections between brain areas were based on known anatomy. Structural equation modelling was used to calculate the path coefficients representing the magnitudes of the functional influences of each area on the ones to which it is connected by anatomical pathways. The encoding and the retrieval network elicit similarities in a general manner but also differences. Strong functional linkages involving visual integration areas, parahippocampal regions, left precuneus and cingulate gyrus were found in both encoding and retrieval; the functional linkages between posterior regions and prefrontal regions were more closely linked during encoding, whereas functional linkages between the left parahippocampal region and posterior cingulate as well as extrastriate areas and posterior cingulate gyrus were stronger during retrieval. In conclusion, these findings support the idea of a global bihemispheric, asymmetric encoding/retrieval network subserving episodic declarative memory. Our results further underline the role of the precuneus in episodic memory, not only during retrieval but also during encoding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00723.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Psoriatische Osteoarthropathie und Skelettszintigraphie (1996)
    Springer
    Der Hautarzt 47 (1996), S. 427-431 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Psoriasis ; Osteoarthropathie ; Skelettszintigraphie ; Key words Psoriasis ; Osteoarthropathy ; Bone scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Psoriasis is a generalized disease that affects bone as well as skin. Three patterns of bone involvement can be differentiated in psoriatic arthritis distal, central, and distal combined with central. Distal involvement is more specific for psoriatic arthritis, with radial and/or transverse involvement of the distal interphalangeal joints. The progression dynamic and the pattern of distribution are different from those pattern of rheumatoid arthritis: psoriatic arthritis originates in the periarticular bone and extends towards the synovia, whereas in rheumatoid arthritis it extends in the opposite direction. In psoriatic arthritis anterior chest wall syndrome, insertion tendinopathies, and localized or diffuse bone disease are often observed. Bone scintigraphy is more sensitive in the diagnosis of psoriatic bone involvement than clinical examination or conventional radiological imaging, allowing earlier diagnosis through the visualization and documentation of specific patterns and presence of disease in multiple sites. It also allows more discriminating selection of subsequent X-ray examinations to limit radiation exposure. Thus, bone scintigraphy is now the most important diagnostic tool in the assessment of psoriatic arthritis.
    Notes: Zusammenfassung Die wichtigsten Manifestationen der Psoriasis sind Haut und Skelettsystem. Bei der psoriatischen Osteoarthropathie werden szintigraphisch drei Manifestationstypen unterschieden: peripher, zentral sowie peripher und zentral. Der periphere Manifestationstyp weist einen Befall im Strahl und/oder einen Transversalbefall der kleinen distalen Interphalangealgelenke von Händen und Füßen auf. Dieses Verteilungsmuster hat spezifischen Charakter. Zur Abgrenzung von der rheumatoiden Arthritis sind die Ausbreitungsdynamik und das Verteilungsmuster von Bedeutung. Die psoriatische Osteoarthropathie geht vom gelenknahen Knochen aus mit Übergreifen auf die Synovia und ist somit entgegengesetzt der Ausbreitungsdynamik der rheumatoiden Arthritis. Bezüglich des Verteilungsmusters, finden sich bei der psoriatischen Osteoarthropathie häufig das „anterior chest wall Syndrom“, Insertionstendinopathien sowie eine lokalisierte und diffuse Osteopathie. Die Skelettszintigraphie ist sensitiver als Klinik und radiologische Diagnostik. Sie erlaubt in einem Untersuchungsgang frühzeitig die Erfassung pathologischer Veränderungen, eine exakte Dokumentation der Befunde, sowie die Darstellung des spezifischen Verteilungsmusters und der Polytopie. Sie ermöglicht weiterhin gezielte Röntgenaufnahmen und damit eine Verringerung der Strahlenbelastung. Die Skelettszintigraphie ist daher die wichtigste Methode zur Beurteilung der psoriatischen Osteoarthropathie (Diagnose, Prognose und Therapiekontrolle).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050445
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Debranching of arabinoxylan: properties of the thermoactive recombinant α-L-arabinofuranosidase fromClostridium stercorarium (ArfB) (1995)
    Springer
    Applied microbiology and biotechnology 43 (1995), S. 856-860 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The genearfB encoding α-L-arabinofuranosidase B of the cellulolytic thermophileClostridium stercorarium was expressed inEscherichia coli from a 2.2-kbEcoRI DNA fragment. The recombinant gene product ArfB was purified by fast-performance liquid chromatography. It has a tetrameric structure with a monomeric relative molecular mass of 52 00. The optima for temperature and pH are 70°C and 5.0 respectively. The enzyme appears to have no metal cofactor requirement and is sensitive to sulfhydryl reagents. It hydrolyzes aryl and alkyl α-L-arabinofuranosides and cleaves arabinosyl side-chains from arabinoxylan (oat-spelt xylan) and from xylooligosaccharides produced by recombinant endoxylanase XynA from the same organism. The identity of the N-terminal amino acid sequences indicates that ArfB corresponds to the major α-arabinosidase activity present in the culture supernatant ofC. stecorarium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431919
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Debranching of arabinoxylan: properties of the thermoactive recombinant α-L-arabinofuranosidase from Clostridium stercorarium (ArfB) (1995)
    Springer
    Applied microbiology and biotechnology 43 (1995), S. 856-860 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  The gene arfB encoding α-L-arabino-furanosidase B of the cellulolytic thermophile Clostridium stercorarium was expressed in Escherichia coli from a 2.2-kb EcoRI DNA fragment. The recombinant gene product ArfB was purified by fast-performance liquid chromatography. It has a tetrameric structure with a monomeric relative molecular mass of 52 00. The optima for temperature and pH are 70 °C and 5.0 respectively. The enzyme appears to have no metal cofactor requirement and is sensitive to sulfhydryl reagents. It hydrolyzes aryl and alkyl α-L-arabinofuranosides and cleaves arabinosyl side-chains from arabinoxylan (oat-spelt xylan) and from xylooligosaccharides produced by recombinant endoxylanase XynA from the same organism. The identity of the N-terminal amino acid sequences indicates that ArfB corresponds to the major α-arabinosidase activity present in the culture supernatant of C. stercorarium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050496
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    Paper (German National Licenses)
    Fulltext
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