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  • 1
    Electronic Resource
    Electronic Resource
    HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP) (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 29 (2002), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/Aim:  There is growing indication that differences in host response determine susceptibility and resistance to periodontal disease. Particularly, the effect of histocompatibility antigens (HLA) on early onset periodontitis (EOP) has been studied. As most of the results are not conclusive and to date no report has been done on German patients, the aim of this study was to investigate the distribution of HLA alleles in a group of 50 German RPP patients and 102 German AP patients and to compare them to 102 control probands without periodontitis.Methods:  Diagnosis was established according to standardised clinical criteria. HLA typing was performed using serologic and molecular biologic (PCR-SSP) techniques.Results: Compared to the controls, RPP patients had a significantly higher frequency of HLA-DRB1*13 and a significantly lower frequency of HLA-DRBblank*(non-DRB3/4/5). AP patients showed a significantly increased occurrence of HLA-B*14 and -Cw*08 as well as a significantly decreased frequency of HLA-A*03. In both patient groups HLA-A*11 and -A*29 had an increased frequency and HLA-A*31 and -A*30/31 were decreased. These differences were statistical significant in the whole patient group (RPP + AP).Conclusions:  Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051X.2002.290614.x
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  • 2
    Electronic Resource
    Electronic Resource
    The three sorCS genes are differentially expressed and regulated by synaptic activity (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 88 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have isolated the murine sorCS3 gene, a new member of the family of receptors containing a Vps10p-domain. Receptors of this family facilitate rapid endocytosis and are thought to be involved in intracellular sorting. SorCS3 and the highly homologous sorCS1 and sorCS2 genes were expressed in a combinatorial, mostly non-overlapping pattern in both the developing and mature central nervous system. During development, distribution and abundancy of their transcripts was regulated. Moreover, their expression was differentially influenced by neuronal activity in the hippocampus of adult mice. Although kainic acid-induced seizures had no effect on sorCS2 mRNA levels, they dramatically increased the expression of sorCS1 and sorCS3. The activity-dependent induction of sorCS1 expression required de novo protein synthesis, whereas that of sorCS3 did not. Our results imply that the three sorCS genes have diverse, but partly overlapping functions in the developing and mature central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2004.02286.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of different luting procedures on the seating of ceramic inlays (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This in vitro study evaluated the effect of different luting procedures on the proper seating of ceramic inlays and on the marginal seal through microleakage testing. Sixty mesial-, occlusal-, distal- (MOD) cavities were prepared in third molars, and distributed among four groups. In the control group 1, the cavity surface was treated with dentin and enamel bonding agents; ceramic inlays were placed into the cavity and light cured. In group 2, the dentin and enamel bonding agents were cured prior to the placing of the inlays, and following the insertion. In group 3, the inlays were luted without enamel bonding. In group 4, the inlays were cemented using a one-bottle bonding and two times light curing. The groups with only one time light curing at the end of the luting process exhibited the smallest luting space following cementation. The smallest dye penetration values were obtained for the two groups with separate light curing of the dentin bonding agent. Reducing the film thickness of polymerized dentin bonding agents, i.e. by changing the composition of the bonding agents, could facilitate proper seating of ceramic inlays together with a better marginal seal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2000.00525.x
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  • 4
    Electronic Resource
    Electronic Resource
    Tensile bond strengths of four different dentin adhesives on irradiated and non-irradiated human dentin in vitro (2001)
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 28 (2001), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study evaluated the influence of irradiation on dentin bond strength. Sixty irradiated and 60 non-irradiated human third molars were used. The irradiation dose of 60 Gy was fractionally applied over 6 weeks (2 Gy day−1, 5 days week−1). All teeth were prepared in a special manner allowing the simulation of intra-pulpal pressure and dentin perfusion. Dentin specimens with a thickness of 2·0 mm were obtained under standardized conditions. The specimens were randomly assigned to four experimental groups. Tensile bond strength of four different dentin bonding agents (Scotchbond™ 1, Solobond Plus®, Prime&Bond™ 2·1 and Syntac®) was evaluated using an Instron Universal testing machine. Pairwise comparison did not show any significant differences between the irradiated and non-irradiated groups. The influence of the different dentin adhesives was significant (P=0·0001; ANOVA). Compared with Solobond Plus® and Prime&Bond™ 2·1, the use of Scotchbond™ 1 resulted in a significantly higher tensile bond strength in non-irradiated specimen (P〈 0·05; closed test procedure based on Kruskal–Wallis test). Within the limitations of an in vitro study, it can be concluded that adhesive restoration procedures can be successfully used in patients irradiated for cancer of the head and neck.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2001.00758.x
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  • 5
    Electronic Resource
    Electronic Resource
    Permeability of dentine after Nd:YAG laser treatment: an in vitro study (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 24 (1997), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary The purpose of this investigation was to determine the effects of Nd:YAG laser treatment on the permeability of dentine. Forty dentine discs were prepared by horizontal sectioning through the middle coronal third of freshly extracted non-carious third molars. After the removal of the pulp the discs were finished with 600 grit and divided into three test groups and one control group (n = 10). For the test groups three different laser power settings were chosen: test group A: 3 × 60 sec, 60 mJ; test group B: 3 × 60 sec, 90 mJ; test group C: 3 × 60 sec, 120 mJ. No laser treatment was performed on the control group. In a two-chamber system the filtration rate of dentine tubules from an exactly defined area of the specimens was measured using a radioactive Ringer solution under a pressure of 30 cm H2O. Permeability measurements were carried out three times prior to lasing, three times immediately following laser treatment and six times after the application of phosphoric acid. Analysis of variance showed a significant influence of the Nd:YAG laser treatment on the permeability of dentine (P 〈 0.001). The mean quotient of non-treated control vs. lased dentine was 2.19 ± 0.86 for the 60 mJ beam, 1.49 ± 0.88 for the 90 mJ beam, and 204 ± 2.17 for the 120 mJ beam. Etching the lased surfaces had a statistically significant influence on the permeability of the dentine only in the 60 mJ group (P 〈 0.001). The data show that the Nd:YAG laser treatment often increases the permeability of smear layer covered dentine but moderates the increase of permeability after etching the surface with phosphoric acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1997.tb00326.x
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  • 6
    Electronic Resource
    Electronic Resource
    Zur gesundheitlichen Bedeutung des Tanzens im Alter (1999)
    Springer
    Zeitschrift für Gerontologie + Geriatrie 32 (1999), S. 207-212 
    Details
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Präventives Training – Belastungsintensität – Seniorentanz – Alterssport ; Key words Preventive exercise – exercise intensity – dance for the elderly – sports for the elderly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In field research, training intensity was tested during three different dances by recording the exercise heart rates. The subjects (twelve women from 59 to 77 years old) were tested once a week three times, over three minutes with a break of three minutes, three weeks in all. The sequence of the dances changed every week. 108 values of the maximum heart rates measured were considered for statistical calculation. 77 percent of these values were above the threshold to reach health related relevance. There was no significant difference between the seperate dances. The results suggest that dancing even of slow dances will have positive effects for a preventive heart-circulatory training, when the exercise program takes into account, within the context of a particular group, the needs of the individual, especially training duration and training frequency.
    Notes: Zusammenfassung In einer Felduntersuchung wurde die Belastungsintensität während dreier, vom Takt und Tanzprofil her unterschiedlicher Tanzformen bei 12 Frauen im Alter von 59 bis 77 Jahren ( {\overline x} = 69 Jahre) mittels Pulsfrequenzmessung erhoben. Die Versuchspersonen wurden jeweils dreimal 3 Minuten lang mit je 3 Minuten Pause belastet, dies insgesamt dreimal im Wochenabstand. Dabei wurde die Abfolge der Tänze von Woche zu Woche variiert. Die erzielten auswertbaren 108 Spitzenwerte lagen zu 77 % oberhalb der Reizschwelle für ein gesundheitsorientiertes Ausdauertraining. Diese Ergebnisse lassen erwarten, daß das Tanzen auch relativ langsamer Tanzformen bei wenig trainierten Frauen im fortgeschrittenen Lebensalter positive Effekte im Sinne eines präventiven Herz-Kreislauf-Trainings verspricht, wenn es im konkreten Fall gelingt, die beim Tanzen erreichbare Belastungsintensität durch weitere, individuell auf die Population abgestimmte Belastungsnormative, insbesondere Belastungsdauer und -häufigkeit, zu ergänzen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003910050106
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  • 7
    Electronic Resource
    Electronic Resource
    Fluoride uptake in dentin with and without simulating dentinal fluid flow (1997)
    Springer
    Clinical oral investigations 1 (1997), S. 125-130 
    Details
    ISSN: 1436-3771
    Keywords: Key words Fluoride ; Dentin ; Dentinal fluid flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to compare fluoride uptake of dentin with and without simulating dentinal fluid flow. Eighty-five dentinal discs were prepared from retained human molars. Seventeen discs were used to assess baseline fluoride content (controls). Sixty-eight discs were evenly distributed among two experimental groups and were fixed for 24 h in a two-chamber device allowing for simulating dentinal fluid flow. Thirty-four samples were treated with dentifrice slurry containing a low fluoride concentration (Elmex, dilution 1:5); the remaining discs were treated with a solution of a high fluoride concentration (Elmex Fluid). For the perfused group, each of the 17 discs of the high and low concentration fluoride groups were constantly perfused during the experiment. The remaining fluoridated specimens were not perfused. All specimens were assayed for KOH-soluble fluoride and structurally bound fluoride. Structurally bound fluoride was determined in three successive layers of 20 µm each. Uptake of KOH-soluble fluoride was significantly higher in the specimens fluoridated with Elmex Fluid compared to the samples treated with the dentifrice slurry. The uptake of KOH-soluble fluoride was not influenced by perfusion of the dentinal discs. However, perfusion resulted in lower acquisition of structurally bound fluoride in the samples treated with the dentifrice slurry. After application of Elmex Fluid, no significant difference was found in the amount of structurally bound fluoride between the perfused specimens and non-perfused samples. It is suggested that further studies on fluoride uptake in dentin should use a model simulating outward dentinal fluid flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007840050023
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  • 8
    Electronic Resource
    Electronic Resource
    Root lesions in a group of 50–60 year-old Germans related to clinical and social factors (1999)
    Springer
    Clinical oral investigations 3 (1999), S. 168-174 
    Details
    ISSN: 1436-3771
    Keywords: Key words Root caries ; Prevalence ; Middle age ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  From a preventive point of view collection of data concerning carious and non-carious cervical tooth defects is definitely important. Consequently, the prevalence and distribution of different root lesions were studied and correlated with behavioral and biological factors in 50- to 60-year-old German individuals (n=298). Additionally, the data were correlated with characteristics concerning oral health and known risk factors such as gender, educational level, and presence of plaque. An interview included questions on sociodemographic and socioeconomic characteristics, dental and general health status, and various behavioral parameters. During clinical examination data concerning coronal and root lesions, restorations, probing depth, gingival bleeding, and dental plaque were obtained. The participants represented a social middle class population with a high awareness of dental health. Obviously, for the participants, known risk factors for root decay such as gender, educational level and plaque index were of minor importance. Factors correlating with root caries were: (a) number of missing teeth, (b) probing depth, (c) smoking habit, (d) regular dental attendance and (e) the reason for the last dental treatment. Additionally, the prevalence of non cariogenic lesions, primarily resulting from increased but wrongly performed oral self care, seems gradually to relieve carious root destruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007840050097
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  • 9
    Electronic Resource
    Electronic Resource
    Immune Escape by Hepatitis B Viruses (2000)
    Springer
    Virus genes 21 (2000), S. 27-37 
    Details
    ISSN: 1572-994X
    Keywords: HBV ; infection ; liver ; hepadnaviruses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatitis B viruses are DNA viruses characterized by their very small genome size and their unique replication via reverse transcription. The circular genome has been efficiently exploited, thereby limiting genome variation, and leaves no space for genes in addition to those essentially needed during the viral live cycle. Hepatitis B viruses are prototype non-cytopathic viruses causing persistent infection. Human hepatitis B virus (HBV), as well as the closely related animal viruses, most frequently are transmitted vertically from mothers to their offspring. Because infection usually persists for many years, if not lifelong, hepatitis B viruses need efficient mechanisms to hide from the immune response of the host. To escape the immune response, they exploit different strategies. Firstly, they use their structural and non-structural proteins multiplely. One of the purposes is to alter the immune response. Secondly, they replicate by establishing a pool of stable extrachromosomal transcription templates, which allow the virus to react sensitively to changes in its microenvironment by up- or downregulating gene expression. Thirdly, hepatitis B viruses replicate in the liver which is an immunopriviledged site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008128212380
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  • 10
    Electronic Resource
    Electronic Resource
    Expression and characterization of the ”laminin binding protein” in hydra (1997)
    Springer
    Cell & tissue research 287 (1997), S. 507-512 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Laminin binding protein (LBP) ; Rapidly cycling cells ; CDC2 kinase ; Cytoplasmic localization ; Hydra vulgaris (Cnidaria) ; Chlorohydra viridissima (Cnidaria)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Recently, a cDNA was isolated from hydra with extensive homology to a mammalian and invertebrate gene which codes for a protein called laminin binding protein (LBP). In this paper we describe the protein expression of the hydra LBP in Escherichia coli. On SDS gels the recombinant hydra LBP displayed an apparent molecular mass of 43 kDa, although the calculated mass, including six additional histidines, is 33.7 kDa. Polyclonal antibodies were produced against the hydra recombinant LBP. The antiserum reacted with a 42-kDa and a 43-kDa protein from Hydra vulgaris and from a multiheaded mutant of Chlorohydra viridissima, respectively. In hydra, LBP RNA and protein were highly expressed in cells with short cell cycles, such as all cells of the interstitial cell lineage, less in slowly cycling epithelial cells, and at very reduced levels or not at all in differentiated cells. Higher expression in the multiheaded mutant of C. viridissima than in H. vulgaris, the cells of which differ in doubling time, hint at a function in cell proliferation. This is supported by the finding that in vitro hydra LBP is a substrate for the cell-cycle-specific kinase CDC2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050774
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