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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of biliary lipid secretion in non-obese cholesterol gallstone patients with normal, young, male volunteers (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1163-1169 
    Details
    ISSN: 1432-1440
    Keywords: Cholesterol gallstones ; Biliary lipid secretion ; Deoxycholic acid ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Measurements of biliary lipid secretion rates were performed in 14 non-obese patients with radiolucent gallstones (9 females, 5 males; mean age 48 years; mean body weight 65 kg) and in 14 healthy male volunteers (mean age 26 years, mean body weight 74 kg). The results in the gallstone patients differ in several respect from those obtained in the volunteers. Molar percentage of cholesterol was higher (5.8 versus 5.0 mol%;P〈0.05) and molar percentage of bile acids lower (73.8 versus 76.9 mol%;P〈0.05) in the gallstone patients. However, these changes were not followed by notable differences in cholesterol saturation of bile (94% vs 88%). Generally, hepatic secretion rates of cholesterol were significantly elevated in the gallstone patients (55 vs 46 mg/h;P〈0.05) whereas outputs of bile acids and phospholipids did not differ between the two groups. Although patients with cholesterol gallstones tended to have a lower percentage of chenodeoxycholic acid (38 versus 42 mol%) and increased deoxycholic acid (23 versus 16 mol%) in their bile, these differences were not significant. Nevertheless, in patients with cholesterol gallstones a significant positive correlation between deoxycholic acid secretion and cholesterol output was observed. For the whole group of patients and volunteers a positive correlation between age and cholesterol secretion could be demonstrated. The higher hepatic cholesterol secretion in gallstone patients seems not be due to differences in body weight, but rather to the older age of the patients. These results suggest that age itself or age-related changes in deoxycholic acid metabolism contributes to biliary cholesterol output in non-obese patients with cholesterol gallstones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740592
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  • 2
    Electronic Resource
    Electronic Resource
    Serum-cholesterol-lowering effect of metronidazole and possible mechanisms of action (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 279-281 
    Details
    ISSN: 1432-1440
    Keywords: Metronidazole ; Bile acids ; Cholesterol absorption ; Serum cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five patients with Crohn's disease long-term therapy with metronidazole (400 mg b.i.d.) was followed by a significant reduction of total serum cholesterol from 179 mg/dl to 156 mg/dl, 134 mg/dl, and 143 mg/dl, after 2–4 months, 6 months, and 9–12 months, respectively. Lipoprotein analysis before and after 3 weeks of administration of metronidazol (400 mg/day) to five normolipemic volunteers revealed that LDL-cholesterol was reduced by 21% (P〈0.05), whereas HDL-cholesterol remained unchanged. Biliary secretion of cholesterol and bile acids were reduced by 13% and 20% (P〈0.05), respectively, which might suggest a decreased sterol synthesis. The amount and percentage of intestinal cholesterol absorption were decreased by 33% and 22% (P〈0.05). Thus, a possible decrease in sterol synthesis and a reduction of cholesterol absorption might be responsible for the serum-cholesterol-lowering effect of metronidazole. However, caution should be taken when considering metronidazole for long-term treatment of patients with hypercholesterolemia due to possible side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731475
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  • 3
    Electronic Resource
    Electronic Resource
    Administration of a terpene mixture inhibits cholesterol nucleation in bile from patients with cholesterol gallstones (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 458-462 
    Details
    ISSN: 1432-1440
    Keywords: Gallstones ; Bile ; Nucleation time ; Cholesterol crystals ; Terpenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with cholesterol gallstones referred to elective cholecystectomy were randomly assigned prior to operation to no treatment (n=14), treatment with one capsule t.d.s. (n=12) or two capsules t.d.s. (n=11) of a terpene mixture (Rowachol). Patients with pigment stones (n=7) or no biliary tract disease (n=5) were also studied. Lipid composition, presence of cholesterol monohydrate crystals, and nucleation time were determined in galbladder bile aspirated during surgery. Cholesterol saturation was similar in the different groups. Crystals were present in all cholesterol gallstone patients without treatment and in none of the controls. In one of the patients treated with one capsule and four of the patients treated with two capsules crystals could not be detected. The terpenes prolonged nucleation time from 2.8 to 5.8 days (one capsule;P〈0.05) and to 9.5 days (two capsules;P〈0.001), respectively; but nucleation did not occur in seven controls. Although the mechanism by which the terpene mixture inhibits the formation of cholesterol crystals in bile was not determined, the findings suggest that the terpene mixture might be a useful agent for a clinical trial to test whether they will prevent recurrence of gallstones after medical dissolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712838
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  • 4
    Electronic Resource
    Electronic Resource
    Differences in the response of serum lipoproteins to fenofibrate between women and men with primary hypercholesterolaemia (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 365-369 
    Details
    ISSN: 1432-1041
    Keywords: Key words Hyperlipoproteinaemia ; Fenofibrate; fenofibric acid ; sex differences ; long-term treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: We studied possible sex differences of the effect of fenofibrate on serum lipoproteins. Twenty-three patients with primary hypercholesterolaemia (10 postmenopausal women and 13 aged-matched men) were treated with slow-release fenofibrate for 96 weeks. Results: Steady state lipoprotein concentrations were reached after 12 and 24 weeks of treatment in women and men, respectively. During the subsequent follow-up the lipoprotein concentrations remained constant. In women total and low-density lipoprotein (LDL) cholesterol decreased from 299 to 234 mg⋅dl−1 and from 210 to 151 mg⋅dl−1, respectively, and in men from 265 to 233 mg⋅dl−1 and from 192 to 160 mg⋅dl−1. The decrease in triglycerides was also more pronounced in women (−42%) than in men (−18%). High-density lipoprotein (HDL) cholesterol increased significantly in women from 53 to 63 mg⋅dl−1 but not in men (45 to 50 mg⋅dl−1). Since the changes in LDL and HDL cholesterol occurred in opposite directions, the decrease in LDL/HDL cholesterol ratio was accentuated in both groups. However, this ratio was decreased almost twofold in women (−41%) compared to men (−23%). Although the serum concentrations of fenofibric acid were 1.3-fold higher in women than in men, which was probably due to the higher body weight in men (1.2-fold), this difference can hardly explain the favorable effect on lipoproteins in women. Conclusion: The present study indicates that fenofibrate might be very effective by reducing the concentrations of atherogenic lipoproteins in postmenopausal women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050124
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  • 5
    Electronic Resource
    Electronic Resource
    Efficient and selective population of high vibrational levels by stimulated near resonance Raman scattering (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 5064-5076 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report the successful application of an optically pumped molecular beam laser for efficient and selective population transfer from v″=0 to high lying vibrational levels of Na2 in the electronic ground state. More than 50% of the molecules in a thermally populated rotational level of v″=0 can be transferred to a state v″(very-much-greater-than)1 with typically ≥75% of the molecules excited out of the initial state found in the predetermined end vibrational level and approximately ≤25% distributed over other levels according to the Franck–Condon factors. The applicability of this technique to the study of collision processes involving vibrationally highly excited levels is discussed. This work also contributes in general to a better understanding of optically pumped dimer lasers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453674
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  • 6
    Electronic Resource
    Electronic Resource
    Vibrational level dependence of Na2–Ne scattering cross sections at very low collision energy (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 2583-2584 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A significant increase in the total integral cross section in (Na)2−Ne collisions with the vibrational level v'' of the sodium molecule in the electronic ground state, at a collision energy of the order of 1 mev is reported. (AIP)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.455053
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  • 7
    Electronic Resource
    Electronic Resource
    Rotational rainbow scattering with large Δ j: Energy dependence of the anisotropy of the Na2–Ne, Ar interaction potential (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 2680-2684 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Differential cross sections for rotational transitions in Na2–Ne, Ar collisions are measured up to very large Δj. It is shown that the energy dependent anisotropy ΔR(E) of the interaction potential can be determined from these data using simple classical relations of ΔR and the rainbow angle θR. Excellent agreement with ab initio data is demonstrated and underlines the usefulness of this concept.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452070
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  • 8
    Electronic Resource
    Electronic Resource
    Supernumerary rotational rainbows in Na2–He, Ne, Ar scattering (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 2685-2688 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report the resolution of supernumerary rotational rainbows for rotationally inelastic ji → jf=0 transitions in Na2–He, Ne, Ar scattering. The relation of the angular position of the supernumerary maxima and the anisotropy ΔR of the interaction potential is established. The analysis yields the energy dependent anisotropy ΔR(E) in very good agreement with data from other sources.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452071
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  • 9
    Electronic Resource
    Electronic Resource
    Angularly resolved vibrational excitation in Na2–He collisions (1986)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 84 (1986), S. 756-763 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report angle-resolved measurements of vi=0 → vf=1 vibrational transitions in Na2–He collisions at an energy of 90 meV. The agreement with calculated cross sections using an ab initio surface is good, both in the angular variation of the cross section as well as with respect to its magnitude relative to the vibrationally elastic process. The calculated (vi=0, ji=0) → (vf=1, jf ) differential cross sections are discussed in some more detail. They show structure, in addition to the rainbow oscillations, related to the fact that the vibrational transition probability vanishes for a specific approach angle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.450573
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  • 10
    Electronic Resource
    Electronic Resource
    Coherent population transfer and dark resonances in SO2 (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 7068-7072 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Highly efficient population transfer between the (0,0,0) and the (9,1,0) vibrational levels of the electronic ground state X˜ 1A1 of SO2 is demonstrated. The process relies on stimulated Raman scattering with adiabatic passage induced by two suitably delayed ultraviolet laser pulses with nearly transform-limited bandwidth. A transfer efficiency of 100% is achieved. The associated dark resonance is observed. Properties of the latter are compared for delayed and fully overlapping pulses. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.471424
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