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  • 1995-1999  (7)
  • 1965-1969  (1)
  • 1960-1964  (4)
  • 1955-1959  (1)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 9189-9193 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 202 (1964), S. 1316-1318 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MITOCHONDRIA catalyse a rapid incorporation of phosphorus-32 from 32Pi or AT32P into a protein-bound phosphohistidine. This phosphohistidine appears to be an intermediate in the formation of ATP from inorganic phosphorus, and has been suggested as a key intermediate in oxidative phosphorylation1-3. ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: We have synthesized a series of non-macrocyclic ligands to FKBP12 that are comparable in binding potency and peptidyl prolyl isomerase (PPIase) inhibition to FK506 itself. We have also solved the structure of one of these ligands in complex with FKBP12, and have compared that structure to the FK506–FKBP12 complex. Consistent with the observed inhibitory equipotency of these compounds, we observe a strong similarity in the conformation of the two ligands in the region of the protein that mediates PPIase activity. Our compounds, however, are not immunosuppressive. In the FKBP12–FK506 complex, a significant portion of the FK506 ligand, its `effector domain', projects beyond the envelope of the binding protein in a manner that is suggestive of a potential interaction with a second protein, the calcium-dependent phosphatase, calcineurin, whose inhibition by the FKBP 12–FK506 complex interrupts the T-cell activation events leading to immunosuppression. In contrast, our compounds bind within the surface envelope of FKBP12, and induce significant changes in the structure of the FKBP12 protein which may also affect calcineurin binding indirectly.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Flüssigkeits-Szintillationszählung zur Bestimmung von14C-markiertem Ametryn in Dünnschichtchromatogrammen wurde eingehend geprüft. Alterung, Löschungseffekt von Trägersubstanz und Adsorptionsmitteln, Temperaturbeständigkeit der Verbindung in adsorbiertem Zustand wurden untersucht. Die Reproduzierbarkeit beträgt 1 bis 2%, die Nachweisgrenze 0,005μg pro Tüpfel, das Signal-Hintergrund-Verhältnis 3∶1. Zur Lokalisierung der Flecken wurde die Fluoreszenzlöschung herangezogen. Die Ausbeute nach 30 Minuten Entwicklung auf Silikagelplatten war ungefähr 90% Ametryn, unabhängig vom Laufmittel. Bei zweidimensionaler Arbeitsweise wurden 75% wiedergefunden. Die Ausbeute aus Wasser- und Bodenproben lag zwischen 78 und 88%.
    Notes: Summary The use of the liquid scintillation counting method for the determination of14C labelled ametryne on thin-layer chromatograms has been thoroughly investigated. Aging, quenching effect of carrier and adsorbents as well as temperature stability of the compound in the adsorbed state have been studied. The method has a reproducibility of 1 to 2% and a detection limit of 0.005μg per spot at a 3 ∶ 1 signal to background ratio. Fluorescence quenching was used for the location of spots on the chromatogram. Recovery studies were carried out by this method. After 30 minutes development on a chromatoplate coated with silicagel, about 90% of the ametryne was recovered independent of solvent system used. About 75% of the ametryne was recovered from a two-dimensional chromatogram. Recoveries of ametryne from water and soil samples ranged between 78 and 88%.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 1242-1243 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To determine whether or not there exist conditions under which unimolecular hydrolysis occurs, we have hydrolysed suitably substituted amides in an acid solvent (95-100 per cent sulphuric acid) which possesses good ionizing properties but contains little free water, and which is therefore ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 42 (1997), S. 404-407 
    ISSN: 1573-2568
    Keywords: IRRITABLE BOWEL SYNDROME ; UROLOGICAL SYMPTOMS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Irritable bowel syndrome patients often complainof urinary symptoms such as frequency, urgency, anddysuria, raising the possibility of inappropriatereferral to the urologist. To resolve this issue, the prevalence of irritable bowel syndrome wascompared in patients attending urological and controlclinics (dermatology and ENT). The overall prevalence ofirritable bowel syndrome was 31.2% in the urological clinic compared with 21.2% in the controls (P〈 0.001), but striking differences emerged, dependingon presenting complaint. Irritable bowel symptoms wereparticularly common in patients presenting with loin pain (male: 40.9%, P = 0.004; female: 50%, P =0.03), dysuria (male: 43.8%, P = 0.007; female: 46.2%,P = 0.01) and frequency/urgency (male: 31.7%, P = 0.002;female: 42.4%, P = 0.006), and the male/femaleprevalence was 24% and 44%. These results suggest that inirritable bowel syndrome, urinary symptoms includingloin pain can present diagnostic dilemmas in both thegastroenterological and urological setting, underlining the importance of specialists in these fieldsworking together in order to define better ways ofmanaging such patients.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 1 (1961), S. 134-141 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract One method of determining the strains on the surface of a metal part is by the use of a birefringent coating. Because of the thickness of the coating, however, the observed fringe order depends not only on the surface strains but also on two other factors, namely, the curvature that the surface undergoes and the variation of strain acrose the thickness of the coating. These thickness effects have already been studied in a paper dealing with one dimensional variations in strain. In the present paper, the solution is extended to a two-dimensional deformation with radial symmetry. An experiment is described in which the surface strains produced by the impact of a bullet on a flat plate are determined from the birefringence of a surface coating taking into account the effects of strain gradients and curvature. The values of surface strain are compared with measurements made by means of a square grid inscribed on the metal surface. A procedure is suggested for determining an unknown surface strain having radial symmetry from the total birefringence of the surface coating when the change in curvature of the metal surface under load is known or can be determined separately.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 1 (1961), S. 74-82 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract It is known that birefringent coatings are a powerful experimental technique for the determination of surface strains of metals or other opaque bodies. In this paper the complete state of strain in such a coating is determined for an arbitrary one-dimensional variation of the displacement at the metal surface. It is shown that strain gradients or curvature of the surface have a pronounced effect on the observed birefringence, and must be taken into consideration. This can be done by means of two correction factors derived in the paper which take into account the elastic properties of the coating and its thickness. An experimental procedure is outlined for determining an unknown distribution of strain at the metal surface on the basis of the observed photoelastic pattern.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 1 (1961), S. 109-112 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 211 (1996), S. 173-179 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The phase behaviour of carbon dioxide confined in VYCOR glass at pressures below that of the bulk triple point (∼0.51 MPa) has been investigated. The temperature at which freezing occurs appears to be pressure dependent below 0.3 MPa. As experiments are performed at successively lower pressures, the confined phase transitions gradually disappear, due to either partial pore filling, or the proximity of the confined triple point.
    Type of Medium: Electronic Resource
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