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  • 1
    Electronic Resource
    Electronic Resource
    High Quality GaAs on Si Grown by CBE (1995)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 196-201 (Nov. 1995), p. 535-538 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.196-201.535.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    H1- and H2-receptor antagonists prevent histamine release in allergic patients after the administration of midazolam-ketamine. A randomized controlled study (1999)
    Springer
    Inflammation research 48 (1999), S. 128-132 
    Details
    ISSN: 1420-908X
    Keywords: Key words: H1-receptor antagonist — H2-receptor antagonist — Midazolam — Ketamine — Allergic disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: The prophylactic effects of H1- and H2-receptor antagonist against histamine release and clinical symptoms (e.g. skin reactions, hemodynamic changes) were examined in 80 allergic patients after the administration of midazolam-ketamine.¶Subject: We examined 80 allergic patients undergoing oral surgery.¶Methods: A prospective randomized controlled study was performed in four groups of 20 patients who received either hydroxyzine (H1-receptor antagonist), chlorpheniramine (H1-receptor antagonist), a combination of chlorpheniramine and famotidine (H1- and H2-receptor antagonist) or a placebo (control) as premedications. Venous blood samples were obtained before introduction as a control and 0.5, 1, 3, 5 min after the administration of midazolam-ketamine in order to measure the plasma histamine level. In addition, any observed hemodynamic changes were simultaneously recorded. The plasma histamine level was measured using the HPLC (high performance liquid chromatography) post-label system.¶Results: The patients who were treated with both chlorpheniramine and famotidine demonstrated a high level of basal plasma histamine compared to the patients who were treated by hydroxyzine alone (p 〈 0.05), and they also showed less histamine release and anaphylactoid reactions during midazolam-ketamine anesthesia. Allergic patients demonstrated a high percentage of eosinophils, with an average of 4.79 ± 3.78%.¶Conclusion: The administration of midazolam-ketamine in allergic patients demonstrated no significant problems. The combined premedication with chlorpheniramine and famotidine was thus found to have the most prophylactic effect against histamine release after the administration of midazolam-ketamine in allergic patients in spite of a high level of basal plasma histamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050435
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  • 3
    Electronic Resource
    Electronic Resource
    Histamine release during the induction of anesthesia with propofol in allergic patients: A comparison with the induction of anesthesia using midazolam-ketamine (1999)
    Springer
    Inflammation research 48 (1999), S. 582-587 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Propofol — Midazolam-ketamine — Allergic patients — Histamine release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: A prospective randomized controlled study was performed for patients with a history of allergy to evaluate the effect of the induction of anesthesia with propofol against histamine release, skin reactions, hemodynamic changes and other clinical symptoms, while also comparing these parameters during the induction of anesthesia with midazolam-ketamine for patients with a history of allergy. ¶Subjects: We examined 40 patients undergoing oral surgery, who had a history of allergy and/or the percentage of eosinophils in the leukocytes was more than 3%. ¶Methods: Forty patients were randomly allocated into two groups and thus received either midazolam-ketamine (M-K group, n = 20) or fentanyl-propofol (propofol group, n = 20) for the induction of anesthesia. Venous blood samples (4 ml each) were obtained before induction as a control and at 0.5, 1, 3, 5 minutes after the administration of each induction agent, and then furthermore at 0.5, 1, 3, 5 minutes after tracheal intubation in order to measure the plasma histamine level by using the HPLC post-label system. In addition, the blood pressure and heart rate were also simultaneously recorded. Skin reactions were also evaluated by two anesthesiologists. ¶Results: The incidence of 50% histamine release during the induction of anesthesia with propofol occurred in 15% of the patients with a history of allergy. Sixteen patients out of 20 (80%) showed a decrease in the systolic blood pressure after the administration of propofol without any evidence of histamine release. The incidence of 50% histamine release, skin reactions and an increase in the heart rate between the two groups were not statistically significant after the administration of each anesthetic agent. Moreover, some patients also demonstrated histamine release after tracheal intubation. Hemodynamic changes after tracheal intubation showed a similar tendency in both groups. No significant difference was observed regarding the incidence of histamine release, skin reactions and hemodynamic changes between both groups after tracheal intubation. ¶Conclusions: Propofol was found to show a similar incidence of histamine release during the induction of anesthesia using midazolam-ketamine, and thus was also found to be a useful induction agent against histamine release for patients with a history of allergy when hydroxizine was used as a premedication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050507
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  • 4
    Electronic Resource
    Electronic Resource
    Interleukin-13 down-regulates the expression of neutrophil-derived macrophage inflammatory protein-1 alpha (1998)
    Springer
    Inflammation research 47 (1998), S. 361-368 
    Details
    ISSN: 1420-908X
    Keywords: Key words: IL-13 — MIP-1 α— Neutrophils — Inflammation — Chemokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To determine whether interleukin-13 (IL-13) possesses anti-inflammatory properties with respect to polymorphonuclear neutrophils (PMNs). Effects of IL-13 on production of the chemokine, macrophage inflammatory protein-1 alpha (MIP-1α), by PMNs were analyzed.¶Subjects: Human peripheral blood PMNs obtained from healthy volunteers.¶Methods: PMNs were stimulated by lipopolysaccharide (LPS) and/or IL-13 for selected periods of time, and MIP-1α expression was assessed by ELISA and Northern blot analysis.¶Results: IL-13 suppressed expression and production of PMN-derived MIP-1α mRNA and protein in a dose- and time-dependent manner. Inhibition of protein synthesis caused significant enhancement of MIP-1α mRNA expression. The inhibitory activity of IL-13 was abrogated, however, in the presence of cycloheximide, suggesting that IL-13's effect was via synthesis of de novo repressor protein(s).¶Conclusions: PMN-derived chemokines are regulated by both proinflammatory and immunomodulatory cytokines. The coordinated production of these substances is likely to be important in the orchestration of inflammatory and immune responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050345
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical characteristics of children with hypoparathyroidism due to 22q11.2 microdeletion (1997)
    Springer
    European journal of pediatrics 157 (1997), S. 34-38 
    Details
    ISSN: 1432-1076
    Keywords: Key words Hypoparathyroidism ; 22q11 deletion ; DiGeorge syndrome ; Graves disease ; Idiopathic thrombocytopenic purpura
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The phenotypes of chromosomal 22q11.2 microdeletion are quite variable among individuals and hypoparathyroidism (HP) constitutes a definite portion of the clinical spectrum. For the correct diagnosis and pertinent follow up of the HP children due to del22q11.2, we tried to delineate the clinical characteristics of such patients. By employing fluorescence in situ hybridization (FISH) to all the patients diagnosed as HP in our clinic, ten possessed the 22q11.2 microdeletion. Among them, the incidence of cardiac defect (5/10), recurrent infection (1/10) and cleft palate (1/10) was modest. Additionally, seven of them had been diagnosed as HP during the infantile period, when their facial abnormality and intellectual problem had not become evident. Notably, two patients were complicated by Graves disease, while the association of idiopathic thrombocytopenic purpura was also observed in two girls. Conclusion HP due to del22q11.2 may be misdiagnosed as idiopathic, especially in an infant who lacks apparent complications like cardiac anomaly. They should be closely followed up for auto-immune complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050762
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  • 6
    Electronic Resource
    Electronic Resource
    Osteopathia striata, short stature, and characteristic facies: a previously unknown skeletal dysplasia (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 631-635 
    Details
    ISSN: 1432-1076
    Keywords: Key words Skeletal dysplasia ; Osteopathia striata ; Short stature ; Dysmorphic facies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two sporadic cases of a hitherto undescribed skeletal dysplasia with short stature and characteristic facies. The present patients, a 6-year-old girl and a 15-year-old boy, were almost equally affected. Craniofacial anomalies included a sloping forehead, bitemporal bulging, sparse medial eyebrows, a prominent nasal bridge, hypertelorism, proptosis, a beaked nose, hypoplastic alae nasi and a pointed chin. Shallow orbits, short anterior cranial fossae and bitemporal bossing found on skull radiograph corresponded with the facial dysmorphism. Thickening of the dorsum sellae was another hallmark in the skull. Skeletal survey revealed mild osteopenia, interpediculate narrowing of the lumbar spine with short neural arches and, most important, osteopathia striata of the long tubular bones. There was no sclerosis of the craniofacial bones. The clinical and radiological findings in the present patients were overall inconsistent with those of previously known skeletal dysplasias and congenital malformation syndromes, which possess osteopathia striata as a cardinal feature. Conclusion The unique clinical and radiological constellation of our patients constitutes a hitherto unknown bone dysplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050680
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  • 7
    Electronic Resource
    Electronic Resource
    Denudation history of the high T/P Ryoke metamorphic belt, southwest Japan: constraints from CHIME monazite ages of gneisses and granitoids (1998)
    Oxford, UK : Blackwell Science Ltd.
    Journal of metamorphic geology 16 (1998), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: CHIME (chemical Th–U-total Pb isochron method) monazite ages were determined for gneisses and granitoids from the eastern and western parts of the Ryoke belt separated by about 500 km. The monazite ages for the gneisses are concentrated between 102 and 98 Ma, and are interpreted as the time of monazite formation under lower amphibolite facies conditions. The peak metamorphism seems to be contemporaneous with the emplacement of the geologically oldest plutons that are dated at c. 95 Ma in both the eastern and western parts. In the eastern part plutonism continued from c. 95 Ma to c. 68 Ma at intervals of 2–10 Ma, whereas in the western part it ceased at c. 85 Ma. The CHIME monazite ages agree well with the relative age of granitoids derived from intrusive relationships of granitoids in both parts. These lines of evidence are incompatible with a current view that the plutonometamorphism in the Ryoke belt becomes younger towards the east. The CHIME monazite ages, coupled with available data on the depth at which the Ryoke metamorphism took place and the emplacement of individual plutons, show that the western part was eroded more rapidly (about 1.5 mm year−1) than the eastern part (about 0.8 mm year−1) over the time span from 91 to 85 Ma. The denudation rates agree well with those in active orogenic belts like the Alps and Himalayas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1525-1314.1998.00057.x
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  • 8
    Electronic Resource
    Electronic Resource
    Archean cherts derived from chemical, biogenic and clastic sedimentation in a shallow restricted basin: examples from the Gorge Creek Group in the Pilbara Block (1998)
    Oxford UK : Blackwell Science Ltd
    Sedimentology 45 (1998), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The 〉3·0 Ga chert sequence of the Gorge Creek Group is exposed at Ord Ranges about 50 km east of Port Hedland in the Pilbara Block. The chert sequence examined in this study is 15 m thick and consists of oxide-rich laminated chert, grey chert (silicified clastic rock), carbonaceous black chert and carbonate-rich laminated chert. Although the cherts have undergone postdepositional silica enrichment, such as cementation and metasomatic silicification, primary precipitation of silica at the site of deposition is indicated by abundant microstructures (mosaic and spherulitic structures). Other primary to early diagenetic components were carbonates, sulphates (gypsum and anhydrite) and organic matter. Although these mineral associations, on the whole, correspond to those of modern marine evaporites, they are different from modern equivalents with respect to abundant precipitation of amorphous silica and presumed primary precipitation of iron-carbonate (siderite). This feature is a possible manifestation of peculiar physicochemical conditions in the water mass from which the chemical sediments were precipitated; compared with modern ocean waters, the concentrations of Fe and Si were significantly higher and the pH value might have been lower. These conditions could be obtained by contributions of Fe- and Si-enriched hydrothermal solutions and continental run-off to the site of deposition.Grey cherts contain detrital quartz and altered Fe–Ti oxides and were formed in a period of input of terrigenous detrital materials. They are characterized by higher concentrations of TiO2, Al2O3, Cr, Ni, Zn, Rb and Zr compared with the other types of chert and by very low (〈 4) Al2O3/TiO2 values. These features are attributed to the supply of terrigenous detrital materials that contain abundant Fe–Ti oxides (ilmenite and titanomagnetite) and fine TiO2 particles. Such detrital materials might have been formed by extensive chemical alteration of source rocks and residual enrichment of Ti relative to Al.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3091.1998.00198.x
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  • 9
    Electronic Resource
    Electronic Resource
    Fluoride Analysis of Apatite Crystals with a Central Planar OCP Inclusion: Concerning the Role of F− Ions on Apatite/OCP/Apatite Structure Formation (1996)
    Springer
    Calcified tissue international 59 (1996), S. 377-384 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Fluoride — Octacalcium phosphate — Apatite — Fluoridation — Enamel mineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. To study the roles of F− ions in the formation of apatite crystals embedding octacalcium phosphate (OCP) lamella in the center of apatite (Ap), a range of the Ap/OCP/Ap lamellar-mixed crystals were synthesized under various concentrations of fluoride ion (F−) from 0.1–1.0 ppm at pH 6.5 and 37°C. The products were analyzed for the F− incorporation, F− distribution, and the amount of OCP and Ap by chemical analysis, X-ray diffraction (XRD), electron probe microanalysis (EPMA), and nuclear magnetic resonance (NMR) techniques. The F− content and the amount of apatite in the crystalline product increased with an increase in the F− concentration in solution, whereas the amount of OCP and the yield of total product decreased. EPMA indicated that F− ions are distributed in the crystals almost homogeneously. The combined analysis suggested that a low-substituted fluoridated hydroxyapatite (FHAp) grew on a small amount of F−-containing OCP or on a surface-reaction layer of OCP, which has accumulated a small amount of F−. The roles of F− ions were hypothesized as the reduction of the growth rate and/or the critical thickness in the a*-axis direction of OCP, the enhancement of hydrolysis of OCP, and the activation of the growth of FHAp, resulting in thinner OCP lamella and thicker apatite lamella in the a*-axis direction with an increase in F− concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900143
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  • 10
    Electronic Resource
    Electronic Resource
    The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma (1997)
    Springer
    Apoptosis 2 (1997), S. 313-318 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; differentiation ; oral squamous cell carcinoma ; vesnarinone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A patient with histopathological recurrent oral cancer with well-differentiated squamous cell carcinoma, was treated with differentiation- and apoptosis-inducing agent, vesnarinone, per os at a dose of 180 mg/day for 56 days and then at a dose of 60 mg/day for 93 days. The vesnarinone administration caused complete remission of the tumour. It has been found by immunohistochemical staining and PCR-SSCP analysis that the recurrent tumour has wild type p53 gene and relative high level of LeY expression as well as DNA fragmentation in the cancer cells, as assessed by nick-end labelling. These findings suggest that the cure of oral squamous cell carcinoma observed in this case might be associated with induction of differentiation and apoptosis of cancer cells by vesnarinone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026493205097
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