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  • 1995-1999  (10)
  • 1
    Electronic Resource
    Electronic Resource
    Adsorption geometries of CO on Cu (211) (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 110 (1999), S. 10522-10525 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The adsorption of CO on Cu (211), serving as model system for the adsorption of CO in stepped surfaces, has been investigated using electron energy loss spectroscopy (EELS). At a surface temperature of 110 K, CO adsorbs nondissociatively and is drawn exclusively to descending step sites in this system. On-top and bridge sites are sequentially populated with the CO axis being perpendicular to the surface. In addition, at low coverage, a molecular state is observed, for which the CO axis is strongly inclined. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.478983
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A confocal fiber-coupled single-lens theta microscope (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 2956-2963 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A confocal theta microscope using a single water-immersion objective lens is described. The system is based on the Zeiss Axioplan universal microscope, such that the illumination light is coupled into, and the detected light out of, the microscope optics via optical fibers attached to the reflector slider of the microscope. Conventional wide-field, laser-scanning confocal, confocal theta, and 4Pi-confocal theta microscopy modes are available with the system. As the design can be easily adapted to other microscopes, objective lenses, and wavelengths, it allows confocal theta techniques to be implemented in many standard systems. The design constraints and specifications for the microscope are given, as well as a demonstration of its performance. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149040
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-resolution axial and lateral position sensing using two-photon excitation of fluorophores by a continuous-wave Nd:YAG laser (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 446-448 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The change in position of fluorescent beads captured inside the focal volume of optical tweezers is monitored using fluorescence emission induced by two-photon absorption of a continuous-wave Nd:YAG laser (λ=1064 nm). The displacement of a bead due to interactions with its environment leads to a fluorescence intensity variation that is used to design a novel spatial sensor. We determine changes in the axial position of a CY3-labeled latex bead with a diameter of 1.03 μm to a precision better than 10 nm. At an intensity of 600 mW/ μm2 the two-photon bleaching rate is lower than 50% per 2000 s. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.118134
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    PSEUDO-PYOSTOMATITIS VEGETANS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 34 (1995), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1995.tb01105.x
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  • 5
    Electronic Resource
    Electronic Resource
    Tuberculosis of the skin: historical perspectives on tuberculin and Bacille Calmette Guérin (1997)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 36 (1997), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1997.00027.x
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  • 6
    Electronic Resource
    Electronic Resource
    CHRONIC ULCERATIVE STOMATITIS WITH STRATIFIED EPITHELIUM-SPECIEIC ANTINUCLEAR ANTIBODIES (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 35 (1996), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. In 1990 a new disease-associated antinuclear antibody was first recognized as a specific immunologic marker for a chronic form of ulcerative stomatitis (cus). Methods. Another case is reported herein and the subject of chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibodies (SES-ANA) is reviewed. Intraoral biopsies from this patient were submitted for microscopic examination and direct immunofluorescence. Indirect immunofluorescence studies were also performed. Serial SES-ANA titers were obtained with the patient on maintenance treatment with hydroxychloroquine. A skin biopsy of a recent lichenoid eruption was obtained and skin explants grown in the serum of this patient were studied in tissue culture with reference to SES-ANA binding and complement fixation. Results. Biopsy and serum studies confirmed a diagnosis of cus with SES-ANA in the patient reported. Skin biopsy showed lichen planus. The patient was treated with hydroxychloroquine with a favorable response. Serial SES-ANA titers did not parallel the disease activity. Among the substantive observations made from skin explants cultured in the serum of this patient was widespread fixation of C3 to the nuclei of basal cells. Conclusions. The case described herein extends the findings in cus to include lichenoid skin lesions. Records show that at least four of 11 cases of cus had skin lesions, whereas all had oral lesions. Stratified epithelium-specific antinuclear antibodies serve as the key marker of cus. Skin explants grown in the serum of this cus patient bind SES-ANA in tissue culture. Sections of explants fix complement. Titers of SES-ANA have been reported to parallel disease activity in one case, but not in the present case. Thus, there appears to be case-to-case variation. The treatment of choice for cus is hydroxychloroquine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1996.tb03000.x
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  • 7
    Electronic Resource
    Electronic Resource
    Relevance of complement fixing antinuclear antibodies (1999)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 38 (1999), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Connective tissue diseases (CTDs) are a heterogeneous group of disorders defined by the association of a variety of clinical manifestations with immunologic and other laboratory findings. Overlap of syndromes and aberrant findings appear rather frequently. Methods Sera of eight antinuclear antibody (ANA) negative, cases of subacute cutaneous lupus erythematosus (SCLE) with antibodies to Ro (SS-A) and a ninth case with clinical and laboratory signs of Sjögren’s syndrome and systemic lupus erythematosus (SLE) were tested for complement (C′) fixing antinuclear antibodies (C-ANAs). The ninth case was examined in depth by direct immunofluorescence (DIF) and a two-step “C + DIF” test of biopsies for C′ fixation to in vivo bound ANAs, as well as serum tests for C-ANA, ANA, and SCLE markers. Results Sera of five of the eight ANA negative, Ro(SS-A) positive SCLE cases had C-ANAs. The ninth case, a 50-year-old woman with clinical and laboratory signs of Sjögren’s syndrome and SLE, gave a strong positive C + DIF reaction in the skin biopsy for in vivo bound ANAs that fix C′, but negative ANAs and C-ANAs in routine serum tests; they revealed antimitochondrial antibodies. Serum tests on normal skin, however, revealed weak ANA and strong C-ANA reactions with in vitro fixed C′. Conclusions ANA negative cases of SCLE or Sjögren’s syndrome may have C-ANAs. A case with Sjögren’s syndrome and signs of SLE had both in vivo and in vitro C′ fixing ANAs. C-ANA tests can aid in the identification of such cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1999.00580.x
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  • 8
    Electronic Resource
    Electronic Resource
    Structure and dynamics of human interphase chromosome territories in vivo (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 241-251 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A new approach is presented which allows the in vivo visualization of individual chromosome territories in the nuclei of living human cells. The fluorescent thymidine analog Cy3-AP3-dUTP was microinjected into the nuclei of cultured human cells, such as human diploid fibroblasts, HeLa cells and neuroblastoma cells. The fluorescent analog was incorporated during S-phase into the replicating genomic DNA. Labelled cells were further cultivated for several cell cycles in normal medium. This well-known scheme yielded sister chromatid labelling. Random segregation of labelled and unlabelled chromatids into daughter nuclei resulted in nuclei exhibiting individual in vivo detectable chromatid territories. The territories were composed of subcompartments with diameters ranging between approximately 400 and 800 nm which we refer to as subchromosomal foci. Time-resolved in vivo studies demonstrated changes of positioning and shape of territories and subchromosomal foci. The hypothesis that subchromosomal foci persist as functionally distinct entities was supported by double labelling of chromatin with CldU and IdU, respectively, at early and late S-phase and subsequent cultivation of corresponding cells for 5–10 cell cycles before fixation and immunocytochemical detection. This scheme yielded segregated chromatid territories with distinctly separated subchromosomal foci composed of either early- or late-replicating chromatin. The size range of subchromosomal foci was similar after shorter (2 h) and longer (16 h) labelling periods and was observed in nuclei of both living and fixed cells, suggesting their structural identity. A possible functional relevance of chromosome territory compartmentalization into subchromosomal foci is discussed in the context of present models of interphase chromosome and nuclear architecture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050686
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  • 9
    Electronic Resource
    Electronic Resource
    The Use of Patent Data for Technological Forecasting: The Diffusion of CNC-Technology in the Machine Tool Industry (1997)
    Springer
    Small business economics 9 (1997), S. 361-381 
    Details
    ISSN: 1573-0913
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract In the 1980s, a dramatic change in the competitive structure of the machine tool industry through the development and implementation of CNC-technology occurred. For the individual company, the timely anticipation and forecast of these technological challenges has been of vital importance in order to incorporate these technological changes into its strategic planning process. This paper assesses the suitability of patent data for forecasting technological developments, based on the experience in the case of CNC-technology. Following a general description of the technological life cycle concept and the discussion of possible benefits of patent data as a technological forecasting tool, actual patenting activity in CNC-technology is analysed. It is found that the diffusion of CNC-technology can be appropriately described by means of patent data. Different development stages in the life cycle of CNC-technology can be distinguished, where for each stage strategic R&D investment decisions can be derived. Analysing the impact of CNC-technology on the trade pattern between Japan and Germany clearly reveals that patenting activity causes subsequent and immediate market changes. The strong Japanese patent position in CNC-technology is closely associated with favourable trade changes. Consequently, it is recommended to incorporate the systematic and continuous monitoring of patenting activity into a company's overall competitor monitoring intelligence. Especially for small and medium-sized enterprises, patent data analysis provides a technological forecasting instrument with high potential benefits and relatively low cost.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007921808138
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  • 10
    Electronic Resource
    Electronic Resource
    On the Thermoelectric Performance of Plasma Spray–formed Iron Disilicide (1998)
    Springer
    Journal of materials science 17 (1998), S. 1487-1490 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026486703748
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    Paper (German National Licenses)
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