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  • 1
    Electronic Resource
    Electronic Resource
    Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection (1996)
    Springer
    Inflammation research 45 (1996), S. 109-112 
    Details
    ISSN: 1420-908X
    Keywords: NG-nitro-L-arginine-methyl-ester (L-NAME) ; NG-monomethyl-L-arginine (L-NMMA) ; N-iminoethyl-L-ornithine (L-NIO) ; Septic shock ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the effects of three nitric oxide synthase inhibitors on survival in a murine sepsis model.Design: Prospective randomized experimental trials.Setting: Laboratory.Subjects: Female Balb/c mice.Interventions:Escherichia coli (108 colony-formingunits/body) were injected into the peritoneal cavities of Balb/c mice. NG-nitro-L-arginine-methyl-ester, NG-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge.Measurements: One hundred and fifteen animals were observed for survival.Results: These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with NG-nitro-L-arginine-methyl-ester (100 mg/kg i.p.) actually reduced survival time afterE. coli challenge.Conclusions: Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265161
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of sporadic mutations in the helix initiation motif of keratin 6 in two pachyonychia congenita patients: further evidence for a mutational hot spot (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Pachyonychia congenita (PC) is a rare, autosomal dominant, ectodermal dysplasia characterized most distinctly by the presence of symmetric nail hypertrophy. In the Jadassohn-Lewandowsky form, or PC-1, additional cutaneous manifestations may include palmoplantar hyperkeratosis, hyperhidrosis, follicular keratoses, and oral leukoker-atosis. Mutations have previously been identified in the 1A helix initiation motif of either keratin 6 or keratin 16 in patients with PC-1. In the current study, we have identified 2 sporadic, heterozygous mutations in the 1A helix region of the K6 isoform (K6a). The first mutation identified was a 3 base pair deletion (K6aΔ N171). The second mutation was a C-to-A transversion resulting in an amino acid substitution (K6a N171K). These data, in combination with previous reports, provide further evidence that this location is a mutational hot spot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00357.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of biquadratic exchange coupling on magnetoresistance and magnetization process in magnetic bilayer systems (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 4430-4432 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An improved model is proposed to deal with the magnetic bilayer systems taking into account the contribution of the anisotropy energy and biquadratic exchange coupling to elaborate on the evolution of the magnetoresistance (MR) ratio and magnetization process. The results indicate that the characteristic behavior of the MR ratio depends distinctly on both the biquadratic coupling constant and the layer thickness. The profile of the MR ratio was found to vary from an inverted bell shape to a concave pyramid with increasing biquadratic coupling strength, and decays sharply with the layer thickness. This model calculation helps us to provide a venue for further understanding the MR or giant magnetoresistance behavior of the magnetic multilayer system. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.370364
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  • 4
    Electronic Resource
    Electronic Resource
    Hysteretic behavior of magnetic particles with dipole interaction (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 5558-5560 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Energy barrier height and coercivity variation of a pair of interacting particles has been studied as a function of the bonding angle β for 0°≤β≤π/2 and applied field using the fixed step Monte Carlo simulation approach supplemented by the perturbation method. Coercivity Hc(β) of the system has local maxima at β=0 and π/2, and a global minimum at β(similar, equals)65°, and remains depressed compared to the noninteracting case for β≤30° at any temperature. The barrier height behaves similarly. Due to the random nature of distribution dipole interaction, on average, leads naturally to a reduction in coercivity and energy barrier height in comparison with the noninteracting case. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.369894
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  • 5
    Electronic Resource
    Electronic Resource
    Human T-lymphotropic Virus Type II Infection inVietnamese Thalassemic Patients (1997)
    Springer
    Archives of virology 142 (1997), S. 1429-1440 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050170
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  • 6
    Electronic Resource
    Electronic Resource
    Envelope gene sequences of human T-lymphotropic virus type I in Taiwan (1996)
    Springer
    Archives of virology 141 (1996), S. 219-229 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three major types of HTLV-I had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HLTV-I isolates. In this study, the envelope gene sequences of HTLV-I from 9 Taiwanese were analyzed. Based on the phylogenetic tree constructed by unweighed pair group method and the sequence homology analysis by GCG computer programs, the envelope gene sequences of HTLV-I proviruses from these 9 Taiwanese belonged to subtype A or subtype B of the cosmopolitan type and were closely related to HTLV-I from Japan. Twelve subtype-specific nucleotide variations were deduced from the comparison of complete or partial envelope gene sequences of 16 HTLV-I isolates of known subtypes as well as those of 9 Taiwanese. These data provided the basis for subtyping the cosmopolitan type of HTLV-I by amplification of envelope gene sequences and restriction fragment length polymorphism studies. A more extensive survey based upon this proposal was warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01718395
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  • 7
    Electronic Resource
    Electronic Resource
    Detection of dural involvement by magnetic resonance imaging in adult patients with acute leukemias – preliminary experience (1995)
    Springer
    Annals of hematology 70 (1995), S. 243-249 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute leukemia ; Dura ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Retrospectively, the dura in 18 adult patients with acute leukemia were evaluated by gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI). Abnormal dural enhancements were detected in three of four patients with positive cerebrospinal fluid (CSF) cytology, in one of five with suspicious central nervous system (CNS) disease, and in two of nine asymptomatic patients. Computed tomography failed to demonstrate any dural abnormality in these six patients. The abnormal dural enhancement was found in either (a) the brain and the spine, (b) the thoracolumbar spine, or (c) the area adjacent to the parenchymal lesions. Three of the patients were in hematological remission stage; disappearance of the abnormal dural enhancement was observed 1–2 months after radiotherapy and high-dose systemic chemotherapy. The results suggest that MRI is a sensitive and noninvasive imaging modality and superior to CT in detecting dural disease in leukemic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784043
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  • 8
    Electronic Resource
    Electronic Resource
    Subtyping of human T-lymphotropic virus type I by amplification of long terminal repeat sequences and restriction fragment length polymorphism analysis in carriers with multiple transfusions (1996)
    Springer
    Annals of hematology 73 (1996), S. 127-134 
    Details
    ISSN: 1432-0584
    Keywords: Key words Human T-lymphotropic virus type I ; Long terminal repeat ; Restriction fragment length polymorphism ; Polymerase chain reaction ; Transfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Five major subtypes of human T-lymphotropic virus type I (HTLV-I) have been proposed: cosmopolitan, Japanese, West African, Central African, and Melanesian. Based on nucleotide variations specific to particular subtypes, it was possible to genotype HTLV-I rapidly by restriction fragment length polymorphism (RFLP) studies following polymerase chain reaction (PCR) . In this study, the restriction patterns of two LTR fragments were analyzed using eight restriction endonucleases (AvaI, Eco57I, BsoFI, NdeI, SacI, DraI, MaeII, and MaeIII). Genotyping of HTLV-I was done in nine patients with adult T-cell leukemia or HTLV-I-associated myelopathy/tropical spastic paraparesis, in three prostitutes, and in 19 carriers with multiple transfusion in Taiwan. The subtyping results of RFLP studies using these eight restriction endonucleases were in accordance with those of phylogenetic analysis. A substitution of G by A at nucleotide position 503, which creates the DraI site but suppresses the SacI site, was found not only in the Japanese subtype but also in a minority of the cosmopolitan subtype. A mutation near the position of subtype-specific nucleotide variations might suppress the restriction site and lead to unexpected restriction patterns. Amplification of more than one proviral fragment and RFLP studies with a group of appropriate restriction endonucleases may provide rapid and accurate genotyping of HTLV-I. More carriers are required to evaluate the possibility of mixed infection with different HTLV-I subtypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050213
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  • 9
    Electronic Resource
    Electronic Resource
    Detection of dural involvement by magnetic resonance imaging in adult patients with acute leukemias — preliminary experience (1995)
    Springer
    Annals of hematology 70 (1995), S. 243-249 
    Details
    ISSN: 1432-0584
    Keywords: Acute leukemia ; Dura ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Retrospectively, the dura in 18 adult patients with acute leukemia were evaluated by gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI). Abnormal dural enhancements were detected in three of four patients with positive cerebrospinal fluid (CSF) cytology, in one of five with suspicious central nervous system (CNS) disease, and in two of nine asymptomatic patients. Computed tomography failed to demonstrate any dural abnormality in these six patients. The abnormal dural enhancement was found in either (a) the brain and the spine, (b) the thoracolumbar spine, or (c) the area adjacent to the parenchymal lesions. Three of the patients were in hematological remission stage; disappearance of the abnormal dural enhancement was observed 1–2 months after radiotherapy and high-dose systemic chemotherapy. The results suggest that MRI is a sensitive and noninvasive imaging modality and superior to CT in detecting dural disease in leukemic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784043
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  • 10
    Electronic Resource
    Electronic Resource
    Suppression of natural killer cell activity in mouse spleen lymphocytes by several dopamine receptor antagonists (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 343-348 
    Details
    ISSN: 1420-9071
    Keywords: Dopamine ; neuroleptics ; natural killer cell ; spleen lymphocytes ; interferon ; interleukin-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of dopaminergic receptor inhibitors such as thiothixine (D1/D2), fluphenazine (D1/D2), trifluoperazine (D1/D2), pimozide (D2), flupenthixol (D1/D2), (+/−)-SKF 83566 (D1), and spiperone (D2) on splenic natural killer (NK) cell cytotoxic activities were assessed in vitro using mouse spleen lymphocytes or enriched NK cells. Both the activities of the splenic NK cell cytotoxicity and the effector-target cell conjugation were suppressed by thiothixine, fluphenazine, and trifluoperazine at concentrations from 2.64 to 14.78 μM. In addition, the augmentation of the cytolytic activity of NK cells induced by interferon-α or interleukin-2 was antagonized by pretreatment with these neuroleptic compounds. However, neither the splenic NK cell cytotoxicity nor the effector-target cell conjugation were affected by treatment with other neuroleptic compounds such as pimozide, flupenthixol, (+/−)-SKF 83566, and spiperone. Thus, it appears that neuroleptic compounds such as thiothixine, fluphenazine, and trifluoperazine may act through the mechanisms other than a dopaminergic pathway to affect the NK cell-target cell interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928892
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