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  • 1
    Electronic Resource
    Electronic Resource
    Total knee and hip arthroplasty in haemophilic patients (1998)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 4 (1998), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the long-term results of three total hip and nine total knee arthroplasties in nine haemophilic patients with disabling pain and end-stage arthropathy. These patients have been followed over a period of 2–12 years (mean 6.9). One patient had a post-operative haematoma, which was evacuated; two patients required manipulation of the knee because of a limited range of motion. There were no infections. At follow-up, all but two patients were completely free of pain; two patients had occasional pain. The functional improvement was impressive with an average increase in the knee score from 37 to 80 points post-operatively. The hip score increased from 36 to 85 points. The range of motion was increased in seven joints, unchanged in two joints and decreased in three. One total hip arthroplasty was revised after 9 years for aseptic loosening. One total knee demonstrated nonprogressive radiographic evidence of aseptic loosening. Median consumption of coagulation factor concentrate in severe haemophiliacs decreased from 47.00 U yr−1 (range 16.000–144.000) before surgery, to 25.000 U yr−1 (range 18.000–132.000) at 2 years after surgery. Conclusion: hip and knee arthroplasty is a valuable option in symptomatic haemophilic patients with disabling arthropathy, in order to obtain pain relief and functional improvement. It is associated with a low rate of complications and may reduce the need for substitution of factor VIII and IX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1998.00183.x
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-GD 3 Antibodies are Potent Activators of Human γ/δ and α/β Positive T Cells (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 41 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ganglioside GD3 has a variety of biological functions. These include stimulatory effects is on proliferation, natural killer activity and cytokine production by freshly isolated peripheral T cells. In this study we have characterized anti-GD3 antibody (MoAb Z21) mediated effects on T cell clones. Our data indicate that α/β TCR CD4+ and CD8+ as well as γ/δ TCR positive T cells can be stimulated resulting in proliferation and cytokine production. This effect could be blocked by cyclosporin A and did not involve the LFA-3 or CD4 molecule. Apart from IFN-γ and IL-2 production by T helper I and T helper 0 cells we have observed production of IL-4 and IL-10 by T helper 2 cells indicating that the GD3 molecule is not a marker for a certain functional T cell subset. In contrast to anti-CD3 mediated activation, the responsiveness of T cells to stimulation via GD3 was dependent on the cell surface expression of the molecule and could be enhanced by costimulation via CD2, CD3, CD26 or CD28. In addition, anti-GD3 antibodies delivered a potent costimulatory signal for antigen-induced proliferation of CD4+ T lymphocytes. In summary, our experiments illuminate the mechanisms of anti-GD3 antibody induced T cell activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03595.x
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  • 3
    Electronic Resource
    Electronic Resource
    Anisotropy of sliding friction on the triglycine sulfate (010) surface (1995)
    Springer
    Applied physics 61 (1995), S. 525-533 
    Details
    ISSN: 1432-0630
    Keywords: 61.16.Ch ; 62.20.-x ; 68.35.Bs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The frictional properties of freshly cleaved (010) surfaces of the ferroelectric TriGlycine Sulfate (TGS) were investigated by combined scanning and friction force microscopy under ambient conditions. A frictional contrast could be observed between domains with different electrical polarity, as well as between terraces inside individual domains which are separated by steps of half of the unit-cell height or an odd multiple of this value. The latter contrast mechanism originates from the arrangement of the molecules at the surface which is chemically homogeneous, but structurally rotated by 180° between different terraces. The resulting asymmetric surface potential gives rise to a frictional anisotropy in different directions that can be detected by the force microscope, as well as to a change of the frictional force between forward and backward scan direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540254
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  • 4
    Electronic Resource
    Electronic Resource
    Anisotropy of sliding friction on the triglycine sulfate (010) surface (1995)
    Springer
    Applied physics 61 (1995), S. 525-533 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 61.16.Ch; 62.20.-x; 68.35.Bs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract.  The frictional properties of freshly cleaved (010) surfaces of the ferroelectric TriGlycine Sulfate (TGS) were investigated by combined scanning and friction force microscopy under ambient conditions. A frictional contrast could be observed between domains with different electrical polarity, as well as between terraces inside individual domains which are separated by steps of half of the unit-cell height or an odd multiple of this value. The latter contrast mechanism originates from the arrangement of the molecules at the surface which is chemically homogeneous, but structurally rotated by 180° between different terraces. The resulting asymmetric surface potential gives rise to a frictional anisotropy in different directions that can be detected by the force microscope, as well as to a change of the frictional force between forward and backward scan direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540254
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  • 5
    Electronic Resource
    Electronic Resource
    Congenital muscular dystrophy with laminin α2 chain deficiency: Identification of a new intermediate phenotype and correlation of clinical findings to muscle immunohistochemistry (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 968-976 
    Details
    ISSN: 1432-1076
    Keywords: Congenital muscular dystrophy ; Laminin ; Extracellular matrix ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The laminins comprise of a family of heterotrimeric proteins of the extracellular matrix. The cross-shaped proteins consist of a heavy α-chain and two light chains, called β and γ. Each group of chains, classified on their sequence identity and domain organization, include different isoforms. A deficiency of the α2 chain of laminin-2, previously termed merosin or M component, was shown to be responsible for one form of congenital muscular dystrophy (CMD). We investigated muscle biopsies of 20 patients with the clinical diagnosis of CMD and histological evidence of muscular dystrophy for the expression of different laminin chains. Patients with evidence of pachygyria/lissencephaly of the CNS were excluded from this series. The immunohistochemical analysis was correlated to clinical findings and MRI data of the brain. Of 20 patients, 11 (55%) revealed complete or near-complete deficiency of the α2 chain in their skeletal muscle specimens. So far none of these patients became ambulant. Of 20 patients 2 showed partial but clear-cut α2 chain-deficiency. These two patients became ambulant at 18 months and 3 years. All 13 patients with complete or partial α2 chain-deficiency demonstrated cerebral white matter changes on MRI. In contrast, 6/7 CMD patients with normal α2 chain expression became ambulant and none of the 6/7 tested showed evidence of cerebral abnormal T2 sequence signal of the myelin on MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02282889
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  • 6
    Electronic Resource
    Electronic Resource
    Rock porosity determination by combination of X-ray computerized tomography with mercury porosimetry (1997)
    Springer
    Fresenius' journal of analytical chemistry 357 (1997), S. 543-547 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract First results are described of coupling of mercury porosimetry with X-ray computerized tomography (CT) as a new combination technique for rock porosity studies. This technique is suitable for rock samples with a pronounced mercury intrusion-extrusion hysteresis and includes CT measurements before and after mercury intrusion. The entrapped portion of mercury, when the pressure after the intrusion into the rock sample is reduced to 0.1 MPa, serves as a contrast agent in the porous network to localize spatial distribution of rock porosity by CT. The results obtained show that the mercury intrusion and therefore the porosity were quite different for the separate mineral phases. Therefore the combination of mercury porosimetry and computer tomography can give 3-D data on mineral-specific porosity distributions with additional pore size information. In contrast to mercury porosimetry as a single method, results of the combination technique with CT represent a direct visualization of porosity variation and do not depend on any special pore network model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050210
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  • 7
    Electronic Resource
    Electronic Resource
    Development of porous and dispersed CRM (1998)
    Springer
    Fresenius' journal of analytical chemistry 360 (1998), S. 393-397 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Porous and finely dispersed certified reference materials (CRM) were certified using the gas adsorption method. The special certification procedure for IUPAC isotherm classification types I, II, and IV is presented for meso- and macroporous materials with special emphasis on specific surface area, specific pore volume and pore width according to standards DIN 66 131, 66 134, and 66 135. Four CRMs (SiO2, α-Al2O3, two transition aluminas) with a macro- and mesopore range are presented. Certification was made on the basis of BCR guidelines in connection with interlaboratory tests (altogether 38 participating laboratories, 44 various gas adsorption apparatus).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050720
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison between different presentations of pore size distribution in porous materials (1999)
    Springer
    Fresenius' journal of analytical chemistry 363 (1999), S. 174-178 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The different presentations of the pore size distribution derived from the gas adsorption method and the mercury porosimetry are connected with some problems. This concerns especially the use of the logarithmically differential pore volume distribution. The incorrect application of this distribution to bimodal pore systems involves the danger of an apparent overemphasizing of larger pores. This effect may also occur using the incremental pore size distribution in case the experimental point spacing considerably increases towards the larger pore radii. The pore volume density distribution defined as the linear derivative of the cumulative pore volume curve with respect to the pore radius has been found the most convenient form among the various kinds of pore volume distribution presentations. It has been shown that the direct comparison between this distribution and the logarithmically differential pore volume distribution is not allowed. Nevertheless, there is a clear connection between these definitions for the pore size distribution so that they are completely equivalent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051166
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  • 9
    Electronic Resource
    Electronic Resource
    Abstracts (1995)
    Springer
    European food research and technology 201 (1995), S. 105-208 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194136
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  • 10
    Electronic Resource
    Electronic Resource
    Abstracts (1995)
    Springer
    European food research and technology 201 (1995), S. 417-520 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01194263
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