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  • 1
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The molecular identity of a gene which encodes the pore-forming subunit (α1G) of a member of the family of low-voltage-activated, T-type, voltage-dependent calcium channels has been described recently. Although northern mRNA analyses have shown α1G to be expressed predominantly in the brain, the detailed cellular distribution of this protein in the central nervous system (CNS) has not yet been reported. The current study describes the preparation of a subunit specific α1G riboprobe and antiserum which have been used in parallel in situ mRNA hybridization and immunohistochemical studies to localize α1G in the mature rat brain. Both α1G mRNA and protein were widely distributed throughout the brain, but variations were observed in the relative level of expression in discrete nuclei. Immunoreactivity for α1G was typically localized in both the soma and dendrites of many neurons. Whilst α1G protein and mRNA expression were often observed in cells known to exhibit T-type current activity, some was also noted in regions, e.g. cerebellar granule cells, in which T-type activity has not been described. These observations may reflect differences between the subcellular distribution of channels that can be identified by immunohistochemical methods compared with electrophysiological techniques.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of superconductivity 8 (1995), S. 441-444 
    ISSN: 1572-9605
    Keywords: Gaplessness ; magnetic impurities ; penetration depth ; Hc2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract The energy gap structure of the cuprates depends strongly on levels of doping. The stoichiometric compoundYBa 2 Cu 3 O 7 displays a peculiar two-gap structure. Oxygen depletion is accompanied by the transition to the gapless state, and this is manifested in various transport, electromagnetic, etc. properties of the material. The temperature dependence of the penetration depth correlates with oxygen content and is characterized by various power laws in an oxygen depleted sample. In other cuprates, overdoping leads to gaplessness and a peculiar dependence of Hc2.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of business ethics 16 (1997), S. 1717-1725 
    ISSN: 1573-0697
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Economics
    Notes: Abstract This study provides evidence regarding the level of ethical cognition of business students at the entry to college as compared to a national norm. It also provides comparative evidence on the effects of group versus individual ethical cognition upon completion of a business ethics course. The Principled Score (P-score) from the Defining Issues Test (DIT) was used to measure the ethical cognition of a total sample of 301 business students (273 entering students plus 28 students in a business ethics course). The results indicate that (1) business students are not significantly different from the national norms at entry to college and (2) group reasoning helps male students improve their P-scores significantly in the business ethics course at a loss of P-score (albeit not statistically significant) for female students.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Geotechnical and geological engineering 15 (1997), S. 47-85 
    ISSN: 1573-1529
    Keywords: Numerical modelling ; mine design ; tabular stopes ; anisotropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Summary This paper presents a rock mechanics design methodology applicable to steeply dipping orebodies typical of many underground hardrock mines. The first stage in the design process is the characterization of the rock mass using bothin situ and laboratory data. The effects of anisotropy on rock mass behaviour are discussed with reference to laboratory and field observations. The second stage involves the use of a number of selected numerical modelling techniques to investigate ground response in the near-field rock mass surrounding the mining excavations. This study shows that the use of several numerical methods in conjunction, allowing for the advantages of each method to be maximized, provides a more comprehensive analysis of the different facets of stope design. This approach differs from those in the literature which seek to compare the different numerical methods in order to select just one method best suited for a problem. The design methodology employed emphasizes the importance of developing an understanding of ground deformation mechanisms as opposed to predicting absolute behaviour.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 22 (1996), S. 283-296 
    ISSN: 0271-2091
    Keywords: laminar flow ; numerical modelling ; particle image velocimetry measurement ; rotating disc ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The fluid flow field within an enclosed cylindrical chamber with a rotating flat disc was calculated using a finite volume computational fluid dynamics (CFD) model and compared with particle image velocimetry (PIV) measurements. Two particular laminar cases near the Transitional flow regime were investigated: Reynolds number Re=2.5×1 4, chamber aspect ratio G (h/Rd)=0.2 and Re=4.2×104, G (h/Rd)=0.217. This enabled direct comparison with the numerical and experimental results reported by other researchers. The computational details and some major factors that affect the computed accuracy and convergence speed are also discussed in detail. PIV results containing some 4300 velocity vector points in each of seven planes for each case were obtained from the flow field parallel to the rotating disc. It was found that PIV results could be obtained in planes within the boundary layers as well as the core flow by careful use of a thin laser illumination sheet and correct choice of laser pulse separation. There was close agreement between numerical results, the present PIV measurements and other reported experimental and numerical results.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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