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  • 1
    Electronic Resource
    Electronic Resource
    Behavior of high energy ions in the GAMMA 10 tandem mirror : Proceedings of the 12th topical conference on high temperature plasma diagnostics (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 834-837 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: In the GAMMA 10 tandem mirror, ion cyclotron range of frequency heating has been used effectively in the central cell. The ion temperature becomes several keV and an ion beta value is a few %. Semiconductor detectors are used for measurement of high energy protons in both parallel and perpendicular directions to the magnetic field line. Observed pitch angle distribution peaks near the cyclotron resonance layer and estimated pressure profile in the axial direction is consistent with the profile from a diamagnetic loop array. Strong temperature anisotropy can drive an Alfvén ion cyclotron (AIC) mode unstable. In a typical discharge, the temporal evolution of the endloss high energy ions has strong correlation with that of the AIC-mode amplitude. The enhancement of the loss of high energy ions due to the AIC mode is suggested. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149491
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  • 2
    Electronic Resource
    Electronic Resource
    Biochemical Markers of Bone Turnover and Bone Loss at the Lumbar Spine and Femoral Neck: The Taiji Study (1999)
    Springer
    Calcified tissue international 65 (1999), S. 198-202 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone metabolic markers — Predictor — Osteoporosis — Epidemiology — Bone mineral density.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The purpose of this study was to ascertain whether biochemical markers of bone turnover predict bone loss. The survey was carried out in Taiji, Wakayama Prefecture, Japan. From a list of inhabitants aged 40–79 years, 400 participants (50 men and 50 women in each of four age groups) were selected randomly. Bone mineral density (BMD) was measured, and blood and urine samples of all participants were examined to obtain values for eight biochemical markers: alkaline phosphatase (ALP), bone Gla protein (BGP), type I procollagen (carboxyterminal peptide of type I procollagen; PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP), and urinary excretion of calcium (Ca), phosphate (P), pyridinoline (Pyr), and deoxypyridinoline (D-Pyr). Each marker was evaluated as a predictor of the rate of bone change in lumbar spine and femoral neck BMD over a 3-year period. The value of Pyr was significantly related to the change of lumbar spine BMD in men (P= 0.009), and that of BGP was found to be significant in women (P= 0.045). By contrast, none of the bone markers significantly correlated with bone loss at the femoral neck. The coefficient of determination at the lumbar spine was 5% and 7% at the femoral neck only. We conclude that biochemical markers of bone turnover cannot predict bone loss rates in middle-aged or elderly Japanese men and women over a 3-year period with sufficient accuracy for use in clinical decision making.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900682
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular analysis of the androgen receptor gene in 4 patients with complete androgen insensitivity (1998)
    Springer
    Archives of gynecology and obstetrics 261 (1998), S. 95-100 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Androgen receptor ; Androgen insensitivity syndrome ; Point mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Androgen insensitivity syndromes are due to defects in the androgen receptor gene. In this study, we analyzed the androgen receptor gene in four cases with complete androgen insensitivity syndrome. In patient 1, one substitutional mutation [arginine (codon CGC) to cysteine (codon TGC) at position 774] of exon F was identified. This position was located in the hormone binding domain and appeared to be one hot spot of mutations because the mutations at the same position in several unrelated cases were reported before. In patient 2, one substitutional mutation [tyrosine (codon TAT) to cysteine (codon TGT) at position 571] of exon B was identified. This position was located in the DNA binding domain. In patients 3 and 4 (siblings), one substitutional mutation [arginine (codon CGA) to glutamine (codon CAA) at position 752] of exon E was identified. Taken together, these abnormalities might be related to the pathogenesis of complete androgen insensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050206
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  • 4
    Electronic Resource
    Electronic Resource
    Use of Intravenous γ-Globulin for Kawasaki Disease: Effects on Cardiac Sequelae (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 19-23 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Gamma-globulin treatment — Kawasaki disease — Cardiac sequelae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The administration of intravenous γ-globulin (IVGG) for Kawasaki disease was investigated throughout Japan in 1993 by obtaining information from pediatric departments in 2652 hospitals that had more than 100 beds. Of 11,221 reported patients, 8958 patients (79.8%) received IVGG treatment. Of all the patients to whom IVGG was administered, the most common total dose was 1000 mg/kg (36.3%) followed by 2000 mg/kg (16.9%) and 1200 mg/kg (16.8%). The treatment was started in 53.8% by day 5 of the illness and in 83.7% by day 7. The proportion of those with cardiac sequelae was higher among patients administered 〉2000 mg/kg or in those started on IVGG on day 9 of their illness or later. The possible reasons are (1) those who were more severely affected were treated with high-dose IVGG earlier; or (2) IVGG does not effectively prevent cardiac sequelae. We concluded that there is a risk of unfavorable effects with IVGG regarding cardiac sequelae when the IVGG dose is 〉2000 mg/kg or if IVGG is started on day 9 or later. We believe that only a randomized controlled trial, undertaken prospectively, can adequately address the question of the optimal use of IVGG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900102
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  • 5
    Electronic Resource
    Electronic Resource
    Determinants of Bone Loss in a Rural Japanese Community: The Taiji Study (1998)
    Springer
    Osteoporosis international 8 (1998), S. 604-610 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Anthropometrical factors – Bone mineral density – Change rate – Cohort study – Menstruation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The objective of this study was to assess the rate of bone loss and characterize its determinants, among the inhabitants of Taiji, a rural Japanese community. A cohort of 2261 inhabitants aged 40–79 years was established using resident registration in 1992. Fifty men and 50 women in each of four age strata between 40 and 79 years were randomly selected and completed a self-administered risk factor questionnaire. Baseline bone density of lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometry in 1993. BMD was measured again on the same participants in 1996. The rates of change of lumbar spine BMD in men in their 40s, 50s, 60s and 70s were 0.20%, 0.34%, 0.43% and 0.28% respectively. Rates in women were –0.35%, –1.02%, –0.10% and –0.20% respectively. At the femoral neck, rates of change in BMD among men in their 40s, 50s, 60s and 70s were 0.09%, –0.07%, 0.34% and 0.31% respectively. Femoral neck rates of change among women were –0.55%, 0.02%, 0.49% and –0.25% respectively. The rate of change of lumbar spine BMD was –0.24% in premenopausal women with regular periods, –1.99% in premenopausal women with irregular periods and –0.33% in postmenopausal women. Anthropometric measurements at baseline were also related significantly to change in bone density. Baseline weight and height were statistically significant predictors of bone loss rate.These data provide estimates of the rate of bone loss among Japanese men and women aged 40– 79 years. They suggest that body build and menstrual function in women are important determinants of bone loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050106
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