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  • 1
    Electronic Resource
    Electronic Resource
    Space Group Determination of Hydroxyapatite and Carbonate Apatite (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 132-136 (Apr. 1997), p. 2037-2039 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/44/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.132-136.2037.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular cloning of a group of mouse pancreatic islet beta-cell-related genes by random cDNA sequencing (1995)
    Springer
    Diabetologia 38 (1995), S. 381-386 
    Details
    ISSN: 1432-0428
    Keywords: Key words Random cDNA sequencing ; MIN6 ; pancreatic islet beta cell.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To understand the molecular basis of glucose concentration-responsive insulin synthesis and secretion from pancreatic islet beta cells, a group of pancreatic islet beta-cell-related cDNAs was cloned. A pair of cDNA libraries was constructed from a mouse pancreatic islet beta-cell line of MIN6, which was cultured in either high glucose or low glucose media. By applying a random cDNA sequencing approach, 503 and 395 independent species were obtained from a total of 1,011 and 762 clones in the high glucose and low glucose library, respectively. The unknown genes comprised the majority of about 70 % independent clones in both libraries. In Northern blot analysis, 311 (69.4 %) of 448 independent clones showed positive signals within 72 h of autoradiographic exposure. Surprisingly, 150 (48.2 %) out of 311 positive clones showed positive signals to MIN6 cells, but not to NIH/3T3 fibroblasts. The expression level of three unknown clones were glucose-concentration dependent. Combination of a random cDNA sequencing approach and Northern blot analysis is useful to obtain a large number of novel genes and islet beta-cell-related genes. [Diabetologia (1995) 38: 381–386]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410274
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  • 3
    Electronic Resource
    Electronic Resource
    A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism (1997)
    Springer
    Diabetologia 40 (1997), S. 412-420 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin resistance syndrome ; mutation ; genotype ; phenotype ; tyrosine kinase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a homozygous missense mutation at position 1092 (substitution of glutamine for arginine) in the tyrosine kinase domain of the insulin receptor in a patient with leprechaunism associated with severe insulin resistance and intrauterine growth retardation. Site-directed mutagenesis as well as analyses of the patient's lymphocytes revealed that this mutation causes a marked decrease in tyrosine kinase activity of the insulin receptor without any defect in insulin binding, which causes severe defects in insulin-stimulated glucose transport, glycogen synthesis and DNA synthesis. Thus, this is the first homozygous mutation resulting in a selective-kinase defect of the insulin receptor. Interestingly, the parents who are cousins and are heterozygous for the mutation have type A insulin resistance syndrome. This correlation between genotype and phenotype in a single pedigree suggests that the severity of the mutation will determine the phenotype. Based upon this assumption, we have been successful in prenatal diagnosis of the fifth child. Furthermore, we have demonstrated the effectiveness of clinical administration of insulin-like growth factor-I (IGF-I) in this patient and in vitro analysis of the patient's skin fibroblasts, suggesting that IGF-I can compensate for insulin action via the IGF-I receptor in a patient almost lacking functional insulin receptors. [Diabetologia (1997) 40: 412–420]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050695
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular cloning of a group of mouse pancreatic islet beta-cell-related genes by random cDNA sequencing (1995)
    Springer
    Diabetologia 38 (1995), S. 381-386 
    Details
    ISSN: 1432-0428
    Keywords: Random cDNA sequencing ; MIN6 ; pancreatic islet beta cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To understand the molecular basis of glucose concentration-responsive insulin synthesis and secretion from pancreatic islet beta cells, a group of pancreatic islet beta-cell-related cDNAs was cloned. A pair of cDNA libraries was constructed from a mouse pancreatic islet beta-cell line of MIN6, which was cultured in either high glucose or low glucose media. By applying a random cDNA sequencing approach, 503 and 395 independent species were obtained from a total of 1,011 and 762 clones in the high glucose and low glucose library, respectively. The unknown genes comprised the majority of about 70% independent clones in both libraries. In Northern blot analysis, 311 (69.4%) of 448 independent clones showed positive signals within 72 h of autoradiographic exposure. Surprisingly, 150 (48.2%) out of 311 positive clones showed positive signals to MIN6 cells, but not to NIH/3T3 fibroblasts. The expression level of three unknown clones were glucose-concentration dependent. Combination of a random cDNA sequencing approach and Northern blot analysis is useful to obtain a large number of novel genes and islet beta-cell-related genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410274
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  • 5
    Electronic Resource
    Electronic Resource
    Structural changes in the hepatopancreas of the rock lobster, Jasus edwardsii (Crustacea: Palinuridae) during development from the puerulus to post-puerulus (1995)
    Springer
    Marine biology 123 (1995), S. 837-844 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract There is evidence for non-feeding in pueruli of palinurid lobsters during their long-distance swim to the coast and the succeeding post-settlement phase until they molt to the juveniles. For a better understanding of the nutritional supply during the puerulus stage, structural changes in the hepatopancreas were studied in post-settlement pueruli and first-molt, postpueruli of the rock lobster, Jasus edwardsii, collected on the southeast coast of the North Island, New Zealand between 1989 and 1990. In newly settled (transparent) pueruli, the epithelium of the hepatopancreas is dominated by presumed “young R-(resorptive) cells”, which are devoid of lipid droplets, but show active uptake of material from the hemolymph through pinocytosis at the basal region. In the fully pigmented puerulus, the hepatopancreas is dominated by R-cells containing massive lipid droplets; also present are small numbers of F-(fibrillar) and B-(blister-like) cells. This increase of lipid inclusion in the R-cells corresponds to the reduction in size of the fat bodies as the lobster develops from the transparent to the pigmented puerulus. After the molt to the post-puerulus, the R-cells are compressed, and the lipid droplets almost disappear, while the B-cells increase both in size and number. A mechanism is proposed in the present paper to explain energy storage and utilization during the puerulus and post-puerulus stages, wherein the fat bodies and the lipid inclusions play a vital role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349128
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  • 6
    Electronic Resource
    Electronic Resource
    Syringobulbia Caused by Delayed Postoperative Tethering of the Cervical Spinal Cord – Delayed Complication of Foramen Magnum Decompression for Chiari Malformation (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 969-973 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Chiari malformation ; Syringobulbia ; Foramen magnum decompression ; Syringosubarachnoid shunt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Postoperative tethering of the high cervical spinal cord is a rare cause of neurological deterioration after foramen magnum decompression (FMD) with duraplasty for Chiari type I malformation. A review of the literature revealed that only 5 cases have been reported. This entity is not widely known to occur as a complication of the common surgical procedure for Chiari type I malformation. A 17-year-old boy experienced rapidly progressive neurological deterioration over a 3-month period. FMD and duraplasty with lyophilized cadaver dura had been performed 8 years previously. Follow-up MR images showed that the cerebrospinal fluid (CSF) space dorsal to the cord was gradually disappearing and that syringobulbia had developed. Opening the dura mater of the posterior fossa revealed dense fibrous scarring, arachnoid thickening over the cervicomedullary area, and tethering the cord to the dura from the medulla to C2. The adhesions were dissected free, and the tethering was released. A syringosubarachnoid (SS) shunt was inserted and duraplasty was performed with an expended polytetrafluoroethylene sheet (Gore-Tex). Postoperative MR images demonstrated that the syringobulbia had completely collapsed and that a dorsal CSF space was present. Follow-up MR images provided significant information on the cervical spinal cord tethering after FMD with duraplasty for Chiari malformation. We encourage sharp surgical detethering and duraplasty with Gore-Tex to avoid retethering. Early recognition and treatment of this unusual but important complication are emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050403
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  • 7
    Electronic Resource
    Electronic Resource
    Interface Reaction and Bondability of Alumina to Titanium (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 207-209 (Feb. 1996), p. 777-780 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.207-209.777.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Erratum to: “Homology of variable major protein genes between Borrelia hermsii and FEMS Microbiology Letters 143 (1996) Borrelia miyamotoi” [FEMS microbiol. lett. 140 (1996) 131–137] (1996)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 143 (1996), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1996.tb08496.x
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  • 9
    Electronic Resource
    Electronic Resource
    Depth profile of trapped charges in oxide layer of 6H-SiC metal–oxide–semiconductor structures (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 282-287 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Oxide layers etched at an angle were fabricated on a 6H-SiC substrate by varying etching time in diluted hydrofluoric acid, and 6H-SiC metal–oxide–semiconductor structures with various oxide thicknesses were formed. High-frequency capacitance–voltage measurements were carried out for determining the change in gate voltages corresponding to the midgap condition as a function of the thickness of the oxide layer, and the depth profile of trapped charge density in the oxide was estimated from the result. It is found that negative charges build up near the 6H-SiC/SiO2 interface, and that positive charges accumulate in the region at 40 nm from the interface. No significant difference is observed in the depth profiles of the trapped charge density between the oxide layers on the carbon and silicon faces. The origin of these trapped charges is discussed in conjunction with the carbon-related compounds in the oxide layers. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362817
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  • 10
    Electronic Resource
    Electronic Resource
    Sensitive detection of magnetic field distribution using scanning interference electron microscope (invited) (abstract) : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 6451-6451 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have implemented interference imaging mode as well as Lorentz imaging mode on a scanning transmission electron microscope (HITACHI HF-2000 with a scanning option; 200 kV accelerating voltage). In the interference mode, a pair of mutually coherent fine probes scan simultaneously across the region of magnetic induction. By monitoring the relative phase change occurring in the probe pair, the variation of the magnetic flux bound by the probe trajectories can be sensed by the universal unit of e/h (−||e||: electron charge and h: Planck's constant). The combined use of this imaging mode with the Lorentz mode which is based on the detection of the probe deflection by Lorentz force facilitates detailed analyses of fringing field around magnetic materials and magnetic induction inside magnetic films. The microscope described above is particularly suited for the study of magnetic storage devices whose microscopic magnetic properties are drawing much attention recently. We show here the results of its application to the observation of field distributions near the MR (magnetoresistive) heads and induction distributions associated with high density longitudinal and perpendicular recording media. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361970
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