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  • 1
    Electronic Resource
    Electronic Resource
    Increased interleukin-12 plasma concentrations in both, insulin-dependent and non-insulin-dependent diabetes mellitus (1998)
    Springer
    Diabetologia 41 (1998), S. 488-488 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050935
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term management of acute respiratory failure in metabolic myopathy (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1406-1409 
    Details
    ISSN: 1432-1238
    Keywords: Keywords Respiratory failure ; Mitochondrial myopathy ; Acid maltase deficiency ; Intermittent positive pressure ventilation ; Carnitine palmitoyl transferase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Objective: To describe how patients cope with the propos-al of treatment with intermittent artificial ventilation after acute respiratory failure due to progressive respiratory muscle weakness. Design: Case series, follow-up study. Setting: Neurological intensive care unit (ICU). Patients: 7 consecutive patients with metabolic myopathy treated for acute respiratory failure between 1983 and 1992. interventions: Intermittent positive pressure ventilation (IPPV) via tracheostomy. Measurements and results: Symptoms of chronic hypoventilation preceded acute respiratory failure for months. With one exception, patients were mainly disabled from respiratory muscle weakness and sleep-related breathing disorders. IPPV was recommended to prevent recurrent respiratory failure. Two of 28.8nthree patients who accepted home IPPV returned to full-time jobs. One patient, who decided against IPPV, died from CO2 narcosis several months after discharge. All patients adhered to the respiratory regimen once instituted. Conclusions: Acute respiratory failure in chronic myopathy is heralded by daytime drowsiness. IPPV, or at least regular monitoring of waking and sleeping partial pressure of carbon dioxide, is highly recommended even if weaning is successful. IPPV improved quality of life. The treatment strategy at discharge from the ICU should be optimal, as patients are reluctant to modify regimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709559
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  • 3
    Electronic Resource
    Electronic Resource
    Long-term management of acute respiratory failure in metabolic myopathy (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1406-1409 
    Details
    ISSN: 1432-1238
    Keywords: Respiratory failure ; Mitochondrial myopathy ; Acid maltase deficiency ; Intermittent positive pressure ventilation ; Carnitine palmitoyl transferase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To describe how patients cope with the proposal of treatment with intermittent artificial ventilation after acute respiratory failure due to progressive respiratory muscle weakness. Design Case series, follow-up study. Setting Neurological intensive care unit (ICU). Patients 7 consecutive patients with metabolic myopathy treated for acute respiratory failure between 1983 and 1992. Interventions Intermittent positive pressure ventilation (IPPV) via tracheostomy. Measurements and results Symptoms of chronic hypoventilation preceded acute respiratory failure for months. With one exception, patients were mainly disabled from respiratory muscle weakness and sleep-related breathing disorders. IPPV was recommended to prevent recurrent respiratory failure. Two of three patients who accepted home IPPV returned to full-time jobs. One patient, who decided against IPPV, died from CO2 narcosis several months after discharge. All patients adhered to the respiratory regimen once instituted. Conclusions Acute respiratory failure in chronic myopathy is heralded by daytime drowsiness. IPPV, or at least regular monitoring of waking and sleeping partial pressure of carbon dioxide, is highly recommended even if weaning is successful. IPPV improved quality of life. The treatment strategy at discharge from the ICU should be optimal, as patients are reluctant to modify regimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709559
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  • 4
    Electronic Resource
    Electronic Resource
    Zooplankton abundance in the River Danube, Austria: the significance of inshore retention (1999)
    Oxford, UK : Blackwell Science, Ltd
    Freshwater biology 41 (1999), S. 0 
    Details
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: 1. Zooplankton density was examined in a free-flowing section of the River Danube, Austria. Spatial and temporal patterns were used to identify mechanisms regulating zooplankton dynamics.2. Zooplankton abundance differed significantly between sampling sites. These differences were the result of variations in water residence time within the habitats. Inshore habitats with low flushing rates act as storage zones for zooplankton.3. The hydrological conditions govern the number and size of storage zones. In the study area, the highest availability of storage zones was observed at medium water level.4. Total zooplankton numbers, total rotifer numbers and the densities of the most abundant rotifer taxa were significantly positively related to the availability of adjacent storage zones.5. The present authors propose that inshore retention capacity, and the hydrological processes and mechanisms controlling the extent of inshore retention may be of major significance in regulated rivers with high water velocities, preventing substantial zooplankton growth in the main channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2427.1999.00412.x
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  • 5
    Electronic Resource
    Electronic Resource
    From a DNA helicase to brittle hair (1998)
    [s.l.] : Nature America Inc.
    Nature genetics 20 (1998), S. 106-107 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A perplexing example of the complexity of genotype-phenotype relationships is provided by XPD, a DNA repair/transcription helicase encoded by the xeroderma pigmentosum (XP) group D gene (ERCC2). It is part of the TFIIH complex, which binds to the promoters of genes and facilitates the initiation ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2396
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of the CELL-DYN® 3500 Haematology Instrument for the Analysis of the Mouse and Rat Blood (1999)
    Springer
    Comparative clinical pathology 9 (1999), S. 92-106 
    Details
    ISSN: 1433-2981
    Keywords: Key words:Blood cell differentiation – Cell-Dyn® 3500 – Flow cytometry – Impedance measurement – Mouse and rat haematology – Reference values
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The objective of this study was to evaluate the performance of the CELL-DYN® 3500 for rat and mouse blood analysis in a routine environment. The WBC (white blood cells), RBC (red blood cells), PLT (platelets) counts and the WBC differential were determined. In addition, the following aspects were studied: within-run precision, day-to-day precision, bias-free paired difference precision; extended ranges of linearity for RBC, HCT (haematocrit), WBC, PLT; carry-over, the effect of blood ageing, cell stability with different anticoagulants; and the normal ranges, the out of range flagging and some typical pathology cases.  The CELL-DYN® 3500 is a multiparameter flow cytometer which counts and differentiates WBC, based on the principle of multi-angle polarised light scatter separation. RBC and PLT are determined by the impedance method. The WBC count is evaluated by both, optical and impedance methods. Reference methods used were according to the ICSH recommendations on blood cell analysis, including manual counts of WBC and platelets, a centrifugal microhaematocrit method and a haemoglobin measurement by spectrophotometry using the WHO haemoglobin standard. All cell counts were compared with the results obtained by our routine blood cell analyser (Contraves AL820), and the WBC differential was compared with the manual microscopic differentiation of the 400 WBC (200 cells differentiated by two technicians).  The following coefficients of vartiation were obtained: within-run precision was 1.2% and 2.7% for WBC; 1.0% and 1.0% for RBC; 1.3% and 0.9% for haematocrit; 2.1% and 2.7% for platelets (rats and mice respectively). Day-to-day precision was performed using human tri-level control blood, and the CVs were found to be 〈1.7% for WBC, 〈1.4% for RBC, 〈1.2% for haemoglobin and 〈6.3% for platelets.  The following ranges of measurement were found to be linear in the rat: WBC: 0.10–20.20×103/μl; RBC: 0.016–14.3×106/μl; haemoglobin: 0.08–26.8 g/dl; haematocrit: 5.0%–77%; platelets: 14.0–1670.0×103/μl. Equal ranges were observed for mouse blood. Carry-over in rat blood was found to be 0.12% for WBC, 0.05% for RBC, 0.15% for haemoglobin and 0.46% for platelets. In mice, similar carry-over results were obtained. The correlation coefficients (Pearson, correlation coefficient) between the CELL-DYN® 3500 and Contraves AL 820 using linear regression analysis were as follows: 0.988 and 0.997 for WBC; 0.986 and 0.920 for RBC; 0.995 and 0.984 for haemoglobin; 0.958 and 0.85 for haematocrit; 0.958 and 0.963 for platelets, for rats and mice, respectively. Correlation coefficients between the CELL-DYN® 3500 and the manual differential of NEU (neutrophils) and LYM (lymphocytes) were higher than 0.8 in rats and higher than 0.9 in mice. Due to the relatively low absolute counts of MONO (monocytes), EOS (eosinophils) and BASO (basophils), only moderate correlation of methods was found.  The CELL-DYN® 3500 was judged to be reliable, accurate and easy-to-use for counting and identifying normal and most of the pathological blood specimens obtained from mice and rats. By using the CELL-DYN® 3500, the time for blood sample analysis can be shortened significantly and provides extensive opportunities to characterise pathological samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005800050017
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of the contraves AL 820 automated haematology analyser for domestic, pet and laboratory animals (1995)
    Springer
    Comparative clinical pathology 5 (1995), S. 130-139 
    Details
    ISSN: 1433-2981
    Keywords: Automated haematology analyser ; Contraves AL 820 ; Electronic cell counter ; Evaluation ; Veterinary haematology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comprehensive evaluation of the automated haematology analyser Contraves AL 820 was initiated to determine the suitability of this instrument for veterinary purposes in domestic, pet and laboratory animal species. The AL 820 (AVL Medical Instruments, Schaffhausen, Switzerland) is an impedance cell counter with automated threshold setting for rapid adaptation to cell characteristics of different animal species. Storage capability for up to 200 data sets with histograms is provided. Excellent precision, linearity and carry-over features of the AL 820 have been demonstrated in tests with rat, mouse, cat, dog, cattle and horse blood samples. Accuracy of haemoglobin and haematocrit measurements with respect to reference methods was characterised by strong linear correlation. The patented cyanide-free AL 820 method for haemoglobin determination compared very well to the haemoglobincyanide reference method. Accuracy of the red blood cell, haemoglobin, haematocrit, mean corpuscular volume, white blood cell count and platelet count parameters was generally good, when compared to the established laboratory routine method (the predecessor model AL 801) or to a high end automated haematology analyser (Abbott Cell-Dyn CD 3500). Although variation of platelet count measurements was greater than variation of all other parameters, it was considered acceptable particularly with respect to the lack of excelling alternatives. Poor accuracy of feline platelet counts was attributed to overlapping size distribution of red blood cells and platelets in this species. The overall favourable acceptance of the AL 820 was based on easy handling, simple maintenance and pronounced flexibility of this instrument at an economical purchase price. A sample volume of 30 µl and a throughput of up to 60 samples per hour are distinct advantages and render the AL 820 suitable for medium-sized laboratories. With few exceptions, the instrument provides reliable results for all major animal species encountered in routine veterinary haematology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00638932
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  • 8
    Electronic Resource
    Electronic Resource
    Mahlzeitenmuster in einer süddeutschen Bevölkerung (1995)
    Springer
    European journal of nutrition 34 (1995), S. 2-9 
    Details
    ISSN: 1436-6215
    Keywords: Ernährungserhebung ; Ernährungstagebücher ; Mahlzeitenmuster ; Nährstoffaufnahme ; Dietary survey ; food records ; meal patterns ; nutrient intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Seven-day food records of the MONICA project Augsburg dietary survey, which were collected between October 1984 and May 1985 in 899 men aged 45–64 years (random sample), were used to analyze meal patterns. Among other variables, the emphasis was placed on meal frequency and rhythm, frequency of meal combinations, place and time of meal intake as well as on the contribution of different meals to selected nutrient intake. Breakfast delivers 17 %, lunch 29 %, and dinner 33 % of the total daily energy intake; all other meals (snacks) deliver 21 % of the energy intake. The mean contribution of the three major meals, such as breakfast, lunch and dinner to daily protein intake is 14 %, 36 %, and 36 %; to fat intake 17 %, 33 %, and 35 %, and to carbohydrate intake 23 %, 25 %, and 29 %, respectively. Data on meal patterns are useful for the development of preventive strategies.
    Notes: Zusammenfassung Mit den Daten aus 899 7-Tage-Ernährungsprotokollen, die in der ersten Ernährungserhebung des MONICA-Projektes Augsburg an Männern zwischen 45 und 64 Jahren (Zufallsstichprobe) zwischen Oktober 1984 und Mai 1985 erhoben wurden, wurden Mahlzeitenmuster untersucht. Der Schwerpunkt lag dabei u.a. auf Mahlzeitenfrequenz und -rhythmus, Häufigkeit von Mahlzeitenkombinationen, Ort und Zeitpunkt des Mahlzeitenverzehrs sowie der Verteilung der Zufuhr ausgewählter Nährstoffe auf die einzelnen Mahlzeiten. Es zeigte sich dabei z.B., daß das Frühstück im Mittel 17 % der täglichen Energiezufuhr liefert, das Mittagessen 29 % und das Abendessen 33 %; 21 % entfallen auf die Zwischenmahlzeiten. Die analogen Verteilungen der Hauptnährstoffe auf die Hauptmahlzeiten lauten für Protein 14 %, 36 %, 36 %; für Fett 17 %, 33 %, 35 % und für Kohlenhydrate 23 %, 25 % und 29 %. Die Ergebnisse stellen praxis- und handlungsorientierte Basisdaten für die Gesundheitsförderung dar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01612778
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  • 9
    Electronic Resource
    Electronic Resource
    Zusammenhang zwischen Ernährungsverhalten und Bildungsstand: Ergebnisse der Ernährungserhebung 1984/85 des MONICA-Projektes Augsburg (1995)
    Springer
    European journal of nutrition 34 (1995), S. 177-182 
    Details
    ISSN: 1436-6215
    Keywords: Ernährungserhebung ; Lebensmittelverzehr ; Nährstoffaufnahme ; Ausbildungsjahre ; Dietary survey ; food consumption ; nutrient intake ; educational attainment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The relationship between educational attainment and dietary behaviour was examined in a South German population of men aged 45 to 64 years. Analyses are based on data from the MONICA Augsburg Dietary Survey 1984/85 (7-day dietary records, n=899). The evaluation of the daily food consumption shows that men with higher educational attainment prefer healthier food items than men with lower educational attainment. The healthier food pattern in men with higher educational attainment is reflected in a lower cholesterol intake and in a higher fibre intake. The mean daily intake of vitamins, minerals and trace elements is better in men with higher educational attainment with the exception of the vitamin niacin. The total daily caloric intake, fat intake and the combination of saturated, monounsaturated and polyunsaturated fatty acids is independent of educational attainment. The percentage of carbohydrates, protein and fat of the total caloric intake is nearly the same in all educational attainment groups. The results concerning food pattern and nutrient intake by educational attainment offer important information with regard to the development of strategies for the improvement of nutrition habits.
    Notes: Zusammenfassung Die Beziehung zwischen Ernährungsverhalten und Bildungsstand wurde an 45- bis 64jährigen Männern in einer süddeutschen Population untersucht. Daten der Ernährungserhebung des MONICA-Projektes Augsburg 1984/85 wurden ausgewertet. Von 899 Teilnehmern (70 % Beteiligung) wurden 7-Tage-Ernährungsprotokolle erhoben. Der tägliche Lebensmittelverzehr macht deutlich, daß Männer mit höherem Bildungsstand eine gesündere Lebensmittelauswahl treffen. Die Auswirkungen des gesünderen Verzehrsmusters auf die Nährstoffzufuhr beschränken sich auf eine geringere tägliche Aufnahme von Cholesterin und eine höhere Aufnahme von Ballaststoffen. Die Versorgung mit Vitaminen, Mineralstoffen und Spurenelementen ist bei höherem Bildungsstand günstiger, mit Ausnahme des Vitamins Niacin. Als weitgehend unabhängig vom Bildungsstand erweist sich die Energiezufuhr, Fettzufuhr und Fettzusammensetzung. Die prozentualen Anteile der Nährstoffe an der Energiezufuhr weisen keine wesentlichen Unterschiede in den Gruppen der Männer mit unterschiedlichem Bildungsstand auf. Die Ergebnisse ermöglichen, anhand von Informationen über Lebensmittelverzehr und Nährstoffaufnahme einer Personengruppe mit bestimmtem Bildungsstand, konkrete Beratungsziele zu stecken und bessere Ansatzpunkte für Präventionsmaßnahmen im Ernährungsbereich zu finden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623155
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  • 10
    Electronic Resource
    Electronic Resource
    Ernährungserhebung bei Erwachsenen in Erfurt 1991/92: Nährstoffaufnahme (1997)
    Springer
    European journal of nutrition 36 (1997), S. 133-142 
    Details
    ISSN: 1436-6215
    Keywords: Ernährungserhebung ; Protokollmethode ; Nährstoffzufuhr ; Vergleich mit Empfehlungen ; neue Bundesländer ; Dietary survey ; weighted record ; nutrient intake ; comparison with guidelines ; eastern Germany
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary A dietary survey using weighted 3-day-records was carried out in the sample of the third MONICA risk-factor survey in the Thuringian city of Erfurt (eastern Germany) in 1991/92. The aim was to collect detailed intake data in a defined population after the first phase of consolidation on the food market after the German reunification. The dietary sample consisted of 1 118 men and 1 179 women aged 20–64 years; we received 469 acceptable records from men and 333 from women. The German national nutrient datafile BLS (version 2.1) was used to code the records and for the transformation into nutrients. Mean energy intake in men was 2 624 kcal per day, 15.3 % came from protein, 40.0 % from fat, 38.5 % from carbohydrates and 6.0 % from alcohol. Corresponding figures for women were 1 916 kcal per day, 15.8 %, 40.5 %, 41.5 % and 2.1 %. Only a small percentage of participants achieved the recommendations of the German Society for Nutrition for the intake of selected nutrients.
    Notes: Zusammenfassung Bei der dritten MONICA Querschnittsstudie in der Stadt Erfurt wurde 1991/92 an einer Stichprobe von 1 118 Männern und 1 179 Frauen im Alter von 20 bis 64 Jahren eine Ernährungserhebung mit offenen 3-Tage-Wiegeprotokollen durchgeführt. Ziel war es u.a., Daten zur Nährstoffzufuhr einer definierten Bevölkerung nach der ersten Phase der Konsolidierung des Lebensmittelmarktes kurz nach der deutschen Wiedervereinigung zu erheben. Von 469 Männern und 333 Frauen konnten Protokolle ausgewertet werden. Zur Kodierung und Transformation in Nährstoffe wurde die Nährwertdatenbank BLS (Version 2.1) verwendet. Die Energiezufuhr beträgt bei den Männern 2 624 kcal pro Tag, davon stammen 15,3 % aus Protein, 40,0 % aus Fett, 38,5 % aus Kohlenhydraten und 6,0 % aus Alkohol. Die entsprechenden Werte für die Frauen sind 1 916 kcal pro Tag, 15,8 %, 40,5 %, 41,5 % und 2,1 %. Nur ein geringer Anteil der Teilnehmer und Teilnehmerinnen erfüllte die Empfehlungen der Deutschen Gesellschaft für Ernährung für die Zufuhr ausgewählter Nährstoffe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611391
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