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  • 1
    Electronic Resource
    Electronic Resource
    Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats (1996)
    Springer
    Diabetologia 39 (1996), S. 275-280 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic nephropathy ; renin angiotensin system ; angiotensinase A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One of the characteristics of early diabetic nephropathy is glomerular hyperfiltration and hyperperfusion. Many factors have been suggested to induce glomerular hyperperfusion among which are an increased production of vasodilatory prostanoids, an increased synthesis of nitric oxide, a reduced responsiveness of afferent glomerular arterioles to vasoconstrictor stimuli due to diabetic metabolic disturbances and a decreased receptor density for angiotensin II. It has been known for years that angiotensin II is formed locally due to the local activation of the renin angiotensin system. The local angiotensin II concentration, however, is not only regulated by the synthesis rate but also by the local degradation through activation of an aminopeptidase. The main finding of the present study was that the mRNA expression and activity of the angiotensin II degrading enzyme, angiotensinase A, was increased twofold in diabetic rats at 5 weeks and that the increase in mRNA expression was suppressed by insulin therapy and short-term treatment with the angiotensin II antagonist saralasin, whereas angiotensinase A enzyme activity was only reduced by saralasin and not by insulin. These results demonstrate that the angiotensin II degrading exopeptidase angiotensinase A is activated in diabetic glomeruli. This increased activity may be an additional mechanism to explain glomerular hyperfiltration and hyperperfusion in early diabetic nephropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418342
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  • 2
    Electronic Resource
    Electronic Resource
    Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats (1996)
    Springer
    Diabetologia 39 (1996), S. 275-280 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic nephropathy ; renin angiotensin system ; angiotensinase A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One of the characteristics of early diabetic nephropathy is glomerular hyperfiltration and hyperperfusion. Many factors have been suggested to induce glomerular hyperperfusion among which are an increased production of vasodilatory prostanoids, an increased synthesis of nitric oxide, a reduced responsiveness of afferent glomerular arterioles to vasoconstrictor stimuli due to diabetic metabolic disturbances and a decreased receptor density for angiotensin II. It has been known for years that angiotensin II is formed locally due to the local activation of the renin angiotensin system. The local angiotensin II concentration, however, is not only regulated by the synthesis rate but also by the local degradation through activation of an aminopeptidase. The main finding of the present study was that the mRNA expression and activity of the angiotensin II degrading enzyme, angiotensinase A, was increased twofold in diabetic rats at 5 weeks and that the increase in mRNA expression was suppressed by insulin therapy and short-term treatment with the angiotensin II antagonist saralasin, whereas angiotensinase A enzyme activity was only reduced by saralasin and not by insulin. These results demonstrate that the angiotensin II degrading exopeptidase angiotensinase A is activated in diabetic glomeruli. This increased activity may be an additional mechanism to explain glomerular hyperfiltration and hyperperfusion in early diabetic nephropathy. [Diabetologia (1996) 39: 275–280]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418342
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  • 3
    Electronic Resource
    Electronic Resource
    Angiotensin converting-enzyme inhibitor treatment reduces glomerular p16INK4 and p27Kip1 expression in diabetic BBdp rats (1999)
    Springer
    Diabetologia 42 (1999), S. 1425-1432 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic nephropathy, cyclin-dependent kinase inhibitors, glomerular hypertrophy, cell cycle arrest, angiotensin II, progression of renal failure.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Renal hypertrophy occurs early in diabetes mellitus and precedes the development of glomerulosclerosis and tubulointerstitial fibrosis. We have previously shown that cultured mesangial cells exposed to high glucose are arrested in the G1-phase of the cell cycle and undergo cellular hypertrophy. High glucose-mediated induction of p27Kip1, an inhibitor of cyclin-dependent kinases, is essential in this process. Further investigations have also shown that p27Kip1 and p21Cip1, other cyclin-dependent kinase inhibitors, are up regulated in the kidneys of mice with Type I (insulin-dependent) as well as Type II (non-insulin-dependent) diabetes mellitus. Our study was undertaken to test a potential effect of short-term treatment with the angiotensin-converting enzyme inhibitor enalapril on the glomerular expression of the cyclin-dependent kinase inhibitors p16INK4, p21Cip1, and p27Kip1 in BBdp rats, an autoimmune model of Type I diabetes.¶Methods. We evaluated p16INK4, p21Cip1, and p27Kip1 protein expression in isolated glomeruli by western blots. We also assessed p27Kip1 positive glomerular cells by immunohistochemistry.¶Results. Glomerular expression of all three cyclin-dependent kinase inhibitors were stimulated in BBdp rats compared with non-diabetic BBdr animals. Enalapril treatment for 3 weeks, started after the onset of diabetes, reduced the glomerular expression of p16INK4 and p27Kip1 but not of p21Cip1. Enalapril also prevented the increase in kidney weights observed in BBdp rats but had no effect on systolic blood pressure or glucose concentrations.¶Conclusion/interpretation. Our data show that enalapril attenuates the glomerular expression of cyclin-dependent kinase inhibitors in diabetes and suggest a molecular mechanism of how angiotensin-converting enzyme inhibitors prevent renal hypertrophy in diabetes. [Diabetologia (1999) 42: 1425–1432]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051314
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  • 4
    Electronic Resource
    Electronic Resource
    Olfactory neuroblastoma: Detection of genomic imbalances by comparative genomic hybridization (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 839-844 
    Details
    ISSN: 0942-0940
    Keywords: Olfactory neuroblastoma ; CGH ; molecular genetic abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Olfactory neuroblastoma (esthesioneuroblastoma) is a very rare tumour of the olfactory mucosa. Morphological features and cytogenetic studies strongly suggest a neuro-ectodermal origin. Up to now, cytogenetic studies are inconsistent. Some of them have proposed that the tumour belongs to the pPNET family. In the present study we describe genomic imbalances in olfactory neuroblastoma in a 46-year-old woman by using the molecular cytogenetic technique — comparative genomic hybridization (CGH) — in order to define the spectrum of genetic abnormalities in the tumour. The anatomical location and morphological findings were the basis for the diagnosis of esthesioneuroblastoma. Immunohistochemical reactions for NSE, synaptophysin, chromogranin A, HNK-l/Leu-7 and S-100 revealed a characteristic immunophenotype. The CGH analysis showed multiple changes including DNA overrepresentations of chromosomes 4. 8, 11 and 14, partial DNA gains of the long arms of chromosomes 1 and 17, deletions of the entire chromosomes 16, 18. 19 and X, and partial losses of chromosomes 5q and 17p. This study represents an early utilisation of the CGH technique in olfactory neuroblastoma and demonstrates that the tumour carries complex chromosomal aberrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411401
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  • 5
    Electronic Resource
    Electronic Resource
    SSONET: Systemunterstützung für mehrseitige Sicherheit in offenen Datennetzen (1999)
    Springer
    Informatik, Forschung und Entwicklung 14 (1999), S. 95-108 
    Details
    ISSN: 0949-2925
    Keywords: Schlüsselwörter:Sicherheitsarchitektur, Mehrseitige Sicherheit, Konfigurierung, Aushandlung, Interoperabilität ; Key words: Security architecture, multilateral security, configuration, negotiation, interoperability ; CR Subject Classifications: C.2.4, H.5.2, K.4.4, K.6.5
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract. We present a prototype of a security architecture. It enables developers and users of distributed applications to employ multilateral security. Users can express their security goals (e.g. confidentiality, anonymity, integrity and accountability) and select the according cryptographic mechanisms. The communicating parties negotiate security goals and mechanisms to secure the communication. Therefore the architecture comprises components for configuration and negotiation as well as so called security gateways. Building on secure local systems it allows to set up flexible multilateral security for distributed applications.
    Notes: Zusammenfassung. Wir stellen eine prototypische Implementierung einer Sicherheitsarchitektur vor. Sie unterstützt Nutzer und Entwickler verteilter Anwendungen bei der Umsetzung bzw. Integration von mehrseitiger Sicherheit. Nutzer können Schutzziele wie Vertraulichkeit, Anonymität, Integrität und Zurechenbarkeit anwendungsbezogen formulieren und ihnen zugeordnete kryptographische Mechanismen konfigurieren. Der konkrete Schutz einer Kommunikation über Datennetze wird zwischen den Partnern ausgehandelt. Heterogenen Anforderungen der Nutzer bzw. Applikationen und heterogenen Eigenschaften der Schutzmechanismen wird durch Architekturkomponenten für Konfigurierung und Aushandlung sowie sog. Sicherheitsgateways Rechnung getragen. Die Architektur setzt jeweils lokal sichere Basissysteme voraus und ermöglicht darauf aufbauend flexible mehrseitige Sicherheit für verteilte Anwendungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004500050129
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  • 6
    Electronic Resource
    Electronic Resource
    Structural Characterization of Vanadiumphosphate Catalysts Generated under Ammoxidation Conditions (1998)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 278-281 (Apr. 1998), p. 660-665 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/03/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.278-281.660.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    〈i〉Ab initio〈/i〉 Structure Analysis of VO(HPO〈sub〉4〈/sub〉) (1998)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 278-281 (Apr. 1998), p. 704-707 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/03/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.278-281.704.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Die Kumarinnekrose – eine lebensbedrohliche Komplikation (1999)
    Springer
    Zeitschrift für Herz-, Thorax- und Gefässchirurgie 13 (1999), S. 228-233 
    Details
    ISSN: 0930-9225
    Keywords: Schlüsselwörter Kumarinnekrose ; Antikoagulation ; Fibrinolyse ; Key words Coumarin necrosis ; anticoagulation ; fibrinolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Coumarin necrosis is a rare, but life-threatening complication when administering coumarin in oral anticoagulant therapy. Predestined areas are the breasts, hips, gluteal region, thighs or lower legs. Thrombotic tendencies, such as congenital or acquired changes in coagulation, lead to a higher risk of coumarin necrosis. A direct, toxic effect of coumarin on the capillary system may also play a role. Although the incidence is only 0.01–0.1%, lethality lies at 15%, the knowledge of this rare complication is important in order to begin with a proper treatment punctually. The therapy of choice is early fibrinolysis.
    Notes: Zusammenfassung Die Kumarinnekrose stellt eine seltene, aber gefährliche Komplikation der oralen Antikoagulation mit Kumarinderivaten dar. Prädilektionsstellen sind Mammae, Hüften, Gesäß, Oberschenkel und Unterschenkel. Thrombophile Situationen, wie angeborene oder erworbene Veränderungen des Gerinnungssystems bedeuten ein erhöhtes Risiko für das Auftreten einer Kumarinnekrose, eine direkt toxische Wirkung der Kumarinderivate auf die Kapillaren spielt möglicherweise ebenfalls eine Rolle. Da die Inzidenz zwar nur 0,01–0,1% beträgt, die Letalität jedoch bei 15% liegt, ist die Kenntnis dieses seltenen Krankheitsbildes wichtig, um eine rechtzeitige Behandlung einleiten zu können. Die Therapie der Wahl ist eine frühzeitige Fibrinolyse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003980050085
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  • 9
    Electronic Resource
    Electronic Resource
    The equation of state of polyamorphic germania glass: A two-domain description of the viscoelastic response (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 102 (1995), S. 6851-6857 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have measured the quasistatic room temperature equation of state of GeO2 glass under hydrostatic conditions to 7.1 GPa. From ambient pressure to 4 GPa the compression displays completely reversible elastic behavior. Above 4 GPa the glass becomes anelastic and exhibits a dramatic increase in the static compressibility. This change in elastic response is concomitant with the onset of the previously reported pressure-induced germanium coordination change. The equation of state data can be quantitatively described by a two-domain model composed of four- and six-coordinated germanium clusters. The model accurately reproduces the previously measured change in the average Ge–O bond length of germania with pressure and rationalizes the different pressure dependent compressional behavior observed in quasistatic and ultrasonic measurements. We further conjecture that the vitreous polyamorphism exhibited by germania glass at high pressures, and the pressure-induced crystal-to-amorphous transition of quartz-isotypic GeO2, both result from similar underlying coordination instabilities in the germania tetrahedral framework. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.469122
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  • 10
    Electronic Resource
    Electronic Resource
    High confinement and high density with stationary plasma energy and strong edge radiation cooling in the upgraded Torus Experiment for Technology Oriented Research (TEXTOR-94) : The 38th annual meeting of the Division of Plasma Physics (DPP) of the American Physical Society (1997)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 4 (1997), S. 1690-1698 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An overview of the results obtained so far for the radiative I-mode regime on the upgraded Torus Experiment for Technology Oriented Research (TEXTOR-94) [Proceedings of the 16th IEEE Symposium on Fusion Engineering (Institute of Electrical and Electronics Engineers, Piscataway, NJ, 1995), Vol. 1, p. 470] is given. This regime is obtained under quasistationary conditions with edge neon seeding in a pumped limiter tokamak with circular cross section. It combines high confinement and high β (up to a normalized beta, βn=2) with low edge q values (down to qa=2.8) and high density even above the Greenwald limit together with dominant edge radiative heat exhaust, and therefore shows promise for the future of fusion research. Bulk and edge properties of these discharges are described, and a detailed account is given of the energy and particle confinement and their scaling. Energy confinement scales linearly with density as for the nonsaturated Ohmic Neo-Alcator scaling, but the usual degradation with total power remains. No deleterious effects of the neon seeding on fusion reactivity and plasma stability have been observed. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.872343
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