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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1990), S. 560-564 
    ISSN: 1432-1076
    Keywords: Acute mastoiditis ; Subperiosteal abscess ; Central nervous system ; Microbiology ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The charts of 73 children (31 girls, 42 boys) aged 4 months to 14 years (mean 4.5 years) with acute mastoiditis managed during a 16-year period were reviewed. Of the patients 36% were less than 24 months old. Retro-auricular swelling was described in 63 of the 73 children, tenderness in 59, erythema in 58, and protrusion of the auricle in 45. A pathological tympanic membrane was noted in 33% of the patients and fever in only 29%. Apart from local inflammation, the most frequent complaints and symptoms were otalgia (n=42), recent upper respiratory tract infections (n=22), and fever alone (n=22). A subperiosteal abscess was found in 36 patients, and CNS involvement in 5. Nearly half of the patients (48%) were on antibiotic therapy at admission. The isolation rates in bacterial cultures from subperiosteal aspirates (81%) and from mastoid mucosa (68%) were considerably higher than from blood cultures (14%) and were not influenced by previously administered antibiotics. Pneumococci (9/32) andStaphylococcus epidermidis (6/32) were the agents most often isolated. The incidence of the bacteria isolated from patients pre-treated with antibiotics differed from the incidence in patients not previously treated. In 24 patients (33%) the lesion healed with antibiotic therapy without mastoid surgery. Myringotomy and the insertion of a ventilation tube is indicated initially, if acute otitis media with effusion is found. In the absence of a subperiosteal abscess and of CNS involvement, a 48-hour trial of intravenous antibiotic therapy, directed also against staphylococci, is justified before mastoid surgery is considered.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Seven hundred patients were investigated prospectively before undergoing chemonucleolysis. A past history of allergy and/or previous exposure to papain, either in food, beverages or drugs, was sought, and a skin-prick test with chymopapain was performed. Based on the results obtained, the subjects were classified into four groups: Group I– 225 non-atopic non-papain-exposed subjects; Group II–285 non-atopic papain-exposed subjects; Group III–69 atopic non-papain-exposed subjects; and Group IV– 121 atopic papain-exposed subjects. Latent sensitization to papain was observed in 0.4% of subjects in Group I, 3.16% in Group II, 5.8% in Group III and 7.4% in Group IV. The odds ratios were 13.8 for atopy and 7.3 for exposure to papain. Interaction between atopy and papain exposure did not result in a significantly greater risk. Neither sex nor age nor a history of a previous drug reaction were risk factors. Only one patient out of the 23 who were sensitive to papain had no risk factor. The 677 skin-test negative patients then underwent chemonucleolysis and none of them had an anaphylactic reaction. This was significantly less frequent: (P= 0-04) than the incidence in a random population (0.45%). Prick tests performed 6 weeks and 6 months after chemonucleolysis revealed newly acquired sensitization in 36% of the patients. Atopy was not a risk factor for this event. Three points are discussed: (i) the negative predictive value of skin-prick tests with chymopapain is confirmed; (ii) subjects likely to be sensitized are atopic and/or have been exposed previously to food or drugs containing papain and therefore they can be identified pre-operatively by a questionnaire; (iii) atopy is a risk factor for the induction of specific IgE to allergens internalized via a mucosal surface but not for those that are injected parenterally.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of metamorphic geology 12 (1994), S. 0 
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Mineral and isotope studies were undertaken on migmatites from the Schwarzwald, Moldanubian zone of the Variscan belt. The aims of the study were to date the migmatite formation and to determine the processes involved in migmatization in order to evaluate their influence on isotopic resetting. Textural evidence and the comparison of mineral compositions from leucosomes and mesosomes of two centimetre-scale migmatite profiles, respectively, suggest that migmatitic textures and mineral assemblages were formed by metamorphic segregation (deformation-enhanced mass transport) rather than by partial melting (anatexis). The results of Rb-Sr thin-slab dating on these profiles indicate that Sr isotopes were not completely reset during migmatization. No true isochron ages, but ages of approximate isotopic homogenization were obtained on the thin slabs by calculating 87Sr/86Sr ratios back to various stages in their evolution. The coincidence of these Rb-Sr data with U-Pb ages of monazites from migmatites and non-migmatitic gneisses shows that gneisses and migmatites were formed during the same high-temperature event in the Carboniferous (330-335 Ma). The observation that high-temperature metamorphism failed to equilibrate Sr isotopes on the centimetre-scale imposes limitations on the use of conventional whole-rock isochron techniques in dating migmatites.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The location of the genes for the major storage protein, phaseolin, was determined in the polytene chromosomes of the embryo-suspensor ofPhaseolus coccineus, cv. Hammond's Dwarf Scarlett, byin situ hybridization with a35S-labelled cloned probe. The genes were adjoined to chromosome pair no. 3. The distribution of the label indicates a puffed state of the sites during embryogenesis of the legume studied. The location of the phaseolin genes was certified by hybridization of a ribosomal DNA probe to the polytene chromosomes, because their position is well known.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Keywords: Parkinson's disease ; Controlled release ; Levodopa ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five levodopa (l-dopa)-treated patients with Parkinson's disease with severe fluctuations of motor performance, plasma l-dopa as well as dopamine levels were measured during 2 days, first under optimal standard l-dopa with peripheral decarboxylase inhibitor (PDI) and then after a dose adjustment period using slow-release l-dopa/benserazide (Madopar HBS) in an open inpatient trial. Three patients benefited from the slow-release preparation; two patients deteriorated with a tendency to have an unpredictable response, a delay to turn “on” with the first dose in the morning, as well as an increase in dyskinesia corresponding to l-dopa cumulation during the day. These problems were subsequently also seen during the follow-up period of 1 year in those patients who benefited from Madopar HBS as inpatients. This might indicate that patient compliance is more difficult with the new formulation. After 1 year all patients had returned to their previous standard l-dopa/PDI treatment. l-Dopa levels continued to fluctuate, but to a lesser degree with Madopar HBS. The equivalent l-dopa dosage had to be increased by 56% (29–100%) with Madopar HBS while mean dopamine levels increased in four patients (by 47–257%) without the occurrence of peripheral side-effects. This implies that with the new formulation more l-dopa is metabolized to dopamine and explains the necessity to increase the equivalent l-dopa dosage.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 103 (1990), S. 609-612 
    ISSN: 1437-1596
    Keywords: PGM-phenotypes ; Enzyme-activity ; Silent allel ; PGM-Phanotypen ; Enzym-Aktivität ; Null-Allel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Enzymaktivität der erythrozytdren Phosphoglucomutase wurde in 142 Hdmolysaten bestimmt. Die PGM-Phänotypen wurden mittels Isoelektrofokussierung auf Polyacrylamid-Gel ermittelt. Dabei konnten 10 verschiedene Phanotypen dargestellt werden. Die mittlere Enzymaktivität dieser 10 Phänotypen weist signifikante Unterschiede auf. Ein stummes Allel bzw. ein Allel mit reduzierter PGM-Aktivität wurde nicht festgestellt. Es zeigte sich eine Korrelataion zwischen Enzymaktivitat und isoelektrischem Punkt der vier Homozygoten.
    Notes: Summary The enzyme activity of phosphoglucomutase (PGM) has been investigated in red cell haemolysates from 142 individuals and compared to the sub-type as determined by isoelectric focusing. The 10 phenotypes showed significant differences in PGM-activity which indicates that there is a correlation between the level of activity and the isolelectric point of homozygotes. No indication of silent alleles or alleles with reduced activity was found in this collective.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 103 (1990), S. 609-612 
    ISSN: 1437-1596
    Keywords: PGM-phenotypes ; Enzyme-activity ; Silent allel ; PGM-Phänotypen ; Enzym-Aktivität ; Null-Allel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Enzymaktivität der erythrozytären Phosphogluco-mutase wurde in 142 Hämolysaten bestimmt. Die PGM-Phänotypen wurden mittels Isoelektrofokussierung auf Polyacrylamid-Gel ermittelt. Dabei konn-ten 10 verschiedene Phänotypen dargestellt werden. Die mittlere Enzymakti-vität dieser 10 Phänotypen weist signifikante Unterschiede auf. Ein stummes Allel bzw. ein Allel mit reduzierter PGM-Aktivität wurde nicht festgestellt. Es zeigte sich eine Korrelataion zwischen Enzymaktivität und isoelektrischem Punkt der vier Homozygoten.
    Notes: Summary The enzyme activity of phosphoglucomutase (PGM) has been investigated in red cell haemolysates from 142 individuals and compared to the sub-type as determined by isoelectric focusing. The 10 phenotypes showed significant differences in PGM-activity which indicates that there is a correlation between the level of activity and the isolelectric point of homozygotes. No indication of silent alleles or alleles with reduced activity was found in this collective.
    Type of Medium: Electronic Resource
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