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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 61 (1993), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The effect of pentobarbital on the induction of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient global ischemia in gerbil brains was investigated by in situ hybridization using cloned cDNA probes selective for each mRNA species. In sham control brains, HSP70 mRNA was scarcely present, whereas HSC70 mRNA was present in most cell populations. After a 5-min occlusion of bilateral common carotid arteries, HSP70 and HSC70 mRNAs were induced together in several cells and were especially dense in hippocampal dentate granule cells at 3 h, but the strong hybridization of the mRNAs continued only in hippocampal CA1 cells by 2 days. At 7 days after the ischemia, CA1 neuronal cell death was apparent, and the HSP70 mRNA disappeared and HSC70 mRNA content returned to the sham level, except for in the CA1 cells. Pretreatment with pentobarbital (40 mg/kg, i.p.) greatly reduced or inhibited the induction of HSP70 and HSC70 mRNAs at both early (3-h) and late (2-day) phases after ischemia. The drug also prevented CA1 cell death at 7 days along with the maintenance of expression of HSC70 mRNA at the sham control level. Hypothermic effects of pentobarbital were noted at 30 and 60 min after the reperfusion, whereas at 2 h there was no statistical significance between the control and drug-treated groups. The great reduction of HSP70 and HSC70 mRNA induction at both early and late phases after ischemia suggests that pentobarbital reduces intra- and/or postischemic stress and may protect CA1 cells from ischemic damage. These effects of the drug may be mainly due to its specific action rather than its hypothermic effects.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 5082-5082 
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The new frames in physics has united the physics of materials and a new terminology of supercorresponding c- and q-number systems is introduced for the classical and quantal physics. In the q-number system, the electron field as represented by the Schrödinger or Dirac wave function is regarded as the electron itself, which interacts with the zero-point photon field and gives the mass renormalization. The new frames can analyze this subject without the divergence difficulty. The resultant decrease in the self-energy of the electron of about 1 eV is proposed to be dependent on the environmental crystal situation, and may become cooperative to generate coherence to the conduction electron-photon coupled system. Our basic c-number equation includes the vector potential of the interacting photon field, the microscopic electronic electric current, the frequency of the considered photon field, the original plasma frequency of the conduction electrons, and an equivalent frequency and the resonance frequency of the bound-state electrons. Placing reasonable values for these constants, we get a detailed k-ω diagram for the photon-electron field complex. By the action of the bound-state electrons, the original plasma frequency of about 4 eV is separated into two, with the lower value of about 1.7 eV (2.6×1015 s−1). This branch crosses the free-photon mode near the same frequency, opening a sharp narrow window for the zero-point free-photon field. The Fermi frequency of the conduction electrons is about the same with the wavelength of about 10 A(ring), which may fit one of the crystal dimensions. The zero-point photon-electron field complex at this frequency may couple to the electron field at the Fermi level through the induced zero-point ripple electron field. The Heisenberg uncertainty, ΔEΔt≥(h-dash-bar), may operate to the window for generating the longer time-space coherence. We call this mechanism CRCG (crystallo-radiative coherence generator).
    Materialart: Digitale Medien
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  • 3
    ISSN: 1432-1920
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 32 (1990), S. 166-167 
    ISSN: 1432-1920
    Schlagwort(e): Gemistocytic astrocytoma ; MR images ; Protein hydration layer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A gemistocytic astrocytoma demonstrating high intensity on both T1W and T2W MR images is reported. Astrocytoma usually shows low density in T1WI. This peculiar astrocytoma showed no hemorrhage, hemosiderin deposits, melanin or iron. Shortening of T1 relaxation time may be caused by protein hydration layer due to protein rich tumor cells.
    Materialart: Digitale Medien
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  • 5
    ISSN: 1432-1920
    Schlagwort(e): Hereditary adult-onset leukodystrophy ; Optic radiation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We describe a family with hereditary adultonset leukodystrophy with sparing of the optic radiations, shown clinically, neuroradiologically and electrophysiologically. All five affected members developed their leukodystrophy in their fourth decade and clinical features steadily progressed. The sparing of the optic radiations is not typical of other leukodystrophies. We suggest that this is a new clinical entity.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 35 (1993), S. 410-411 
    ISSN: 1432-1920
    Schlagwort(e): Amyotrophic lateral sclerosis ; Motor area ; Single photon emission tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To study degeneration in the central nervous system in amyotrophic lateral sclerosis (ALS), we studied four patients using single photon emission tomography (SPECT) and magnetic resonance imaging (MRI). MRI demonstrated high intensity along the pyramidal tract on T2-weighted images in two. SPECT demonstrated reduced isotope uptake restricted to the motor area. While the cause of degeneration of the cortical neurons in the motor area is unknown, SPECT is useful for detecting the degeneration in patients with ALS.
    Materialart: Digitale Medien
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  • 7
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance ; Olivary hypertrophy ; Palatal myoclonus ; Extremity myorhythmia ; Pontine tegmental hematoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Two patients with unilateral olivary hypertrophy (OH) following a pontine tegmental hematoma are presented. Both showed palatal myoclonus and one patient showed an extremity myorhythmia on the opposite side of OH. the magnetic resonance (MR) examination demonstrated an abnormal unilateral hyperintense lesion in the ventral part of medulla oblongata on T2-weighted images. The MR findings were highly suggestive of the pathological nature of the lesion, showing the value of MR.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Neuroradiology 34 (1992), S. 205-206 
    ISSN: 1432-1920
    Schlagwort(e): Pure sensory stroke ; Thalamic hemorrhage ; Corticothalamic tract
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Pure sensory stroke has not previously been reported with thalamic haemorrhage and had indeed been considered to exclude cerebral haemorrhage. We describe a case of thalamic haemorrhage causing a pure sensory stroke and propose that we should tear in mind the possibility of haemorrhage in such cases.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular medicine 72 (1994), S. 448-450 
    ISSN: 1432-1440
    Schlagwort(e): Parathyroid ; Crisis ; Kidney ; Bone ; Turnover
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Parathyroid crisis occurring in primary hyperparathyroidism is characteized by extremely high circulating levels of parathyroid hormone and acute onset of severe hypercalcemia. We describe a 62-year-old woman with parathyroid crisis probably due to an intraturnoral hemorrhage. Renal dysfunction reduced the effectiveness of preoperative management and continued to deteriorate for 5 days after parathyroidectomy. The normalization of serum calcium after parathyroidectomy delayed and it took 6 days. Maintenance of renal function is important for pre- and postoperative courses of the present case. The rapid decrease in serum parathyroid hormone after parathyroidectomy was followed by a rapid and transient (about fivefold) increase in serum alkaline phosphatase with peak value on the 10th postoperative day. This indicated that reversal phase from bone resorption (accelerated by parathyroid hormone) to bone formation lasted about 10 days under the conditions of the present case.
    Materialart: Digitale Medien
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  • 10
    ISSN: 1432-0827
    Schlagwort(e): Pseudohypoparathyroidism ; Thiazide ; Kidney ; Bone ; Parathyroid hormone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract We compared the effect of orally administered 100 mg of hydrochlorothiazide (HCTZ) among eight patients with pseudohypoparathyroidism (PHP) type I, 11 patients with idiopathic hypoparathyroidism (IHP), and 12 patients with primary hyperparathyroidism (1oHPT). Patients with PHP type I or with IHP were studied during the treatment with 1α-hydroxylated metabolites of vitamin D3. HCTZ raised serum levels of calcium (Ca) in 1oHPT (P〈0.001) and PHP type I (P〈0.01) but did not increase urinary excretion of Ca. Serum parathyroid hormone (PTH) in PHP type I decreased (P〈0.02) after HCTZ administration in response to the increase in serum Ca. HCTZ did not raise serum levels of Ca in IHP but increased urinary excretion of Ca in this group (P〈0.01). HCTZ suppressed tubular reabsorption of phosphate (P) in IHP (P〈0.01) and 1oHPT (P〈0.05) but not in PHP type I. Urinary excretion of cAMP did not change after HCTZ administration in PHP type I, IHP, or 1oHPT. Endogenous PTH modulated the effects of HCTZ on Ca mobilization from bone and renal reabsorption of Ca in PHP type I with normal or high serum levels of PTH and in 1oHPT with high serum levels of PTH. The inhibitory effect of HCTZ on renal tubular reabsorption of P (probably from proximal tubules) was independent of PTH. The resistance to this inhibitory effect of HCTZ on P reabsorption in PHP type I suggested a proximal tubular dysfunction in this disorder.
    Materialart: Digitale Medien
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