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  • 1
    Electronic Resource
    Electronic Resource
    Medifoxamine: Oral tolerance and pharmacokinetic study in healthy human volunteers (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 169-171 
    Details
    ISSN: 1432-1041
    Keywords: antidepressant ; medifoxamine ; tolerance ; pharmacokinetics healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Medifoxamine is a monoamine reuptake inhibiting antidepressant drug. We have investigated its pharmacokinetics in normal healthy volunteers. After an overnight fast, ascending doses of 200, 500, 750 and 1000 mg of medifoxamine were taken orally. Plasma samples were analysed using a specific HPLC method. Medifoxamine was well tolerated and exhibited a first order linear pharmacokinetic profile. It underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration. Thereafter the elimination profile was biphasic with a mean terminal half life less than 3 hours. We found a linear relationship (r=0.80) between administered dose and AUC values for the four doses. High values were obtained for the apparent volumes of distribution and the plasma clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280053
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antagonism by domperidone of the ocular hypotensive effect of pergolide (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 461-463 
    Details
    ISSN: 1432-1041
    Keywords: domperidone ; pergolide ; dopaminergic agonists ; intraocular pressure ; non-contact tonometer ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1 The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 μg pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method. 2 Compared with domperidone followed after 1 h by placebo, placebo followed after 1 h by pergolide had an ocular hypotensive effect in both eyes. Domperidone followed after 1 h by pergolide had no effect on intraocular pressure in both eyes. 2 The results of this study showed that domperidone inhibited the ocular hypotensive action of pergolide, suggesting that pergolide reduces introcular pressure by the stimulation of the peripheral dopamine 2-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336684
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  • 3
    Electronic Resource
    Electronic Resource
    Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 41-45 
    Details
    ISSN: 1432-1041
    Keywords: Bradykinin ; Captopril ; Indomethacin ; laser Doppler ; cutaneous blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of indomethacin and captopril on local cutaneous blood flow changes and weal induced by intradermal injections of bradykinin were assessed in two randomised, double-blind, placebo-controlled studies in healthy volunteers. Alterations in cutaneous blood flow were estimated by laser Doppler flowmetry (LDF) and erythema area. LDF output, erythema area and weal volume increased with incremental bradykinin dose. Single doses of indomethacin 25 mg and 75 mg did not affect these cutaneous responses compared with placebo. Captopril 25 mg significantly potentiated the increase in local cutaneous blood flow measured by LDF, but not erythema area, and weal volume induced by bradykinin. The effects of the combined treatment of indomethacin 75 mg and captopril 25 mg were not significantly different from those due to captopril alone. The enhanced cutaneous effects of bradykinin following administration of captopril are in keeping with effective kininase II inhibition in the tissues. Cyclo-oxygenase products release does not appear to contribute to the cutaneous actions of bradykinin nor the potentiation of these responses by captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315278
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 63-67 
    Details
    ISSN: 1432-1041
    Keywords: Mexiletine ; Debrisoquine hydroxylation phenotype ; pharmacokinetic ; variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine-type may have on mexiletine pharmacokinetics was considered in this study. The pharmacokinetics and urinary excretion of mexiletine (250 mg administered intravenously) were investigated in 5 rapid extensive metabolisers (EM), 5 slow EM and 5 poor metabolisers (PM) of debrisoquine, under conditions of controlled urinary pH. Mexiletine disposition kinetics was found to be altered in PM individuals. These subjects showed higher total area under the curve (AUC), (15.7 versus 8.16 μg · h · ml−1) prolonged elimination half-lives (in serum and urine) (serum: 18.5 versus 11.6 h, urine: 19.2 versus 11.7 h) and lower total clearance values compared with EM (216 versus 450 ml · min−1). In this respect, slow EM individuals generally presented intermediate values of those pharmacokinetic parameters. A higher incidence of adverse-effects was also observed among slow EM and PM subjects. It is concluded that genetic differences in mexiletine oxidation of the debrisoquine-type have an influence on its observed pharmacokinetic variability. The clinical consequences are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315282
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  • 5
    Electronic Resource
    Electronic Resource
    Metabolic studies of taloximine and its effects on the respiratory response to carbon dioxide (1970)
    Springer
    European journal of clinical pharmacology 2 (1970), S. 155-160 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Taloximine is a phthalazine derivative with a respiratory stimulant action on the peripheral chemoreceptors. Peak plasma levels of taloximine after oral administration coincided with peak hyperventilation accompanied by a respiratory alkalosis, a, fall in venous pCO2, and a rise in plasma and urinary pH. — Taloximine was excreted in urine and bile. Metabolites included a phthalazinone, demethylated taloximine and other metabolites in ring hydroxylated form. Sulphated and glucuronated taloximine and metabolites were formed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420343
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  • 6
    Electronic Resource
    Electronic Resource
    An examination of a possible pharmacokinetic interaction between nifedipine and antipyrine (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 405-407 
    Details
    ISSN: 1432-1041
    Keywords: Nifedipine ; antipyrine ; interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of 2 weeks oral intake of nifedipine (2×20 mg) on the oxidative metabolism of antipyrine was investigated in 12 normal volunteers, who had 1050 mg antipyrine solution orally before and after the course of nifedipine. There were no statistically significant differences in the saliva pharmacokinetic parameters of antipyrine on both occasions. However, the metabolite profile of antipyrine in urine showed a significant reduction in the amount of norantipyrine excreted after compared to that before nifedipine administration (16.5 vs 19.6%). This may have implications for drugs that share a similar demethylation pathway with norantipyrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315420
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  • 7
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance study of acid-base interactions for the chloranil electrode system in acetonitrile (1972)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 246-248 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100646a018
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  • 8
    Electronic Resource
    Electronic Resource
    Microwave signal processing for a cryogenic gravitational radiation antenna with a noncontacting readout (1993)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 3191-3197 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A modified version of the microwave signal processing system for the 1.5 tonne niobium bar gravitational radiation antenna at the University of Western Australia has been developed and tested during preparations for long-term observation. Among the new features of the system are a noncontacting microwave coupling to the motion transducer, cryogenic low-noise amplification, and automatic carrier suppression with improved long-term stability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1144327
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  • 9
    Electronic Resource
    Electronic Resource
    Noncontacting microwave coupling to a cryogenic gravitational radiation antenna (1993)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 1905-1909 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Gravitational radiation detectors must detect extremely small displacements, and thus require elaborate vibration isolation systems to attenuate the surrounding environmental noise. Contacting electrical leads can provide a direct path that will short circuit the vibration isolation, and degrade the antenna Q factor. Noncontacting microstrip transceivers provide a practical means of electromagnetically coupling to a resonant bar gravitational antenna when a microwave transducer is used as a signal readout system. Two microwave patch antennas now operate as transceivers on the University of Western Australia's 1.5 tonne niobium bar gravitational radiation antenna and are described in detail in this paper. This system allows improved vibration isolation without degradation of the acoustic Q factor of the niobium bar. Combined with a cryogenic amplifier, this system should achieve a reduction of 57 dB in the series noise power. This corresponds to a factor of 700 reduction in the effective displacement noise when referred to the transducer, from 2×10−16 to 3×10−19 m/(square root of)Hz.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1143975
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Effect on plasma lipids and lipoproteins of postmenopausal oestrogen therapy with added dydrogesterone (1990)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 97 (1990), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. In a prospective, randomized, cross-over study, 14 postmenopausal women completed 9 months of treatment with conjugated equine oestrogens, 1.25 mg daily. Seven women added dydrogesterone 20 mg daily for 12 days during months 2, 3 and 4, and then 10 mg daily for an identical time in months 5,6 and 7. The other seven women added the two dydrogesterone doses in reverse sequence. No dydrogesterone was taken during months 8 and 9. Lipids and lipoproteins were measured before treatment and at the end of months 4, 7 and 9. Lipids were also estimated in an untreated (reference) group of eight postmenopausal women on two occasions 6 months apart; these showed significant changes in HDL2- and HDL3-cholesterol. In the treatment group, HDL-cholesterol and apolipoprotein (apo) Al were significantly higher and LDL-cholesterol and apo B were significantly lower at months 4, 7 and 9 compared with baseline values. Triglyceride levels were increased significantly over baseline values, but remained within the normal range. No significant differences between the two dydrogesterone doses were observed on any lipid and lipoprotein fraction, nor were there any differences between the oestrogen-only and oestrogen/dydrogesterone treatment phases. Dydrogesterone appears to cause little, if any, lipid and lipoprotein changes and assessment in a larger population of postmenopausal women is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1990.tb02496.x
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