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  • 1
    Electronic Resource
    Electronic Resource
    An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice (1990)
    Springer
    Diabetologia 33 (1990), S. 713-718 
    Details
    ISSN: 1432-0428
    Keywords: LZ-8 ; immunomodulator ; NOD mouse ; Type 1 (insulin-dependent) diabetes ; insulitis ; autoimmunity ; T cell subset
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ling Zhi-8 (LZ-8), a novel and recently discovered immunomodulatory protein having in vivo immunosuppressive activity, was tested for in vivo effect against Type 1 (insulin-dependent) diabetes mellitus in the non-obese diabetic mouse, the disease having immunologically mediated aetiology in this animal. LZ-8 had mitogenic activity in vitro towards spleen cells of the non-obese diabetic mice as previously shown towards those of DBA/2 mice. Intraperitoneal administration of LZ-8 twice weekly into the mice (10.3–12.6 mg/kg body weight) from 4 weeks of age prevented insulitis and an almost normal number of insulin producing cells were observed. Extreme insulitis and reduction of the number of insulin producing cells were observed in the pancreata of the untreated non-obese diabetic mouse. No cumulative incidence of diabetes mellitus was observed in the LZ-8 treated group, while cumulative incidences of 70% and 60% were observed in an untreated group followed up to 42 weeks of age when the incidence of diabetes was defined as a plasma glucose level of greater than 11 mmol/l and as a urine glucose level of greater than 2 +, respectively. T cell subset population analysis was performed to further investigate the action of LZ-8 on the non-obese diabetic mouse which revealed that LZ-8 treatment increased in L3T4+/Lyt-2+ ratio.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400340
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  • 2
    Electronic Resource
    Electronic Resource
    An adaptive mesh refinement technique for the analysis of shear bands in plane strain compression of a thermoviscoplastic solid (1992)
    Springer
    Computational mechanics 10 (1992), S. 369-379 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We have developed an adaptive mesh refinement technique that generates elements such that the integral of the second invariant of the deviatoric strain-rate tensor over an element is nearly the same for all elements in the mesh. It is shown that the finite element meshes so generated are effective in resolving shear bands, which are narrow regions of intense plastic deformation that form in high strain-rate deformation of thermally softening viscoplastic materials. Here we assume that the body is deformed in plane strain compression at a nominal strain-rate of 5000 sec-1, and model a material defect by introducing a temperature perturbation at the center of the block.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363993
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Erratum: "Gettering of donor impurities by V in GaAs and the growth of semi-insulating crystals'' [J. Appl. Phys. 66, 3309 (1989)] (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 1621-1621 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.346112
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution mechanism of voids in Si-implanted GaAs (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 70 (1991), S. 656-660 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Voids, formed by the condensation of an excess of implantation-induced vacancies, have been recently identified as the defect directly responsible for dopant diffusion and electrical activation anomalies in Si-implanted and annealed GaAs and GaAs/AlGaAs superlattice materials. Depending on the implanted dose, voids can be distributed either throughout the implanted region or in two bands. We have examined the origin of this void distribution difference. In the as-implanted sample associated with the latter case, a buried continuous band of amorphous GaAs has formed. GaAs formed by the recrystallization of amorphous GaAs does not contain excess vacancies and therefore cannot form voids. However, on either side of the amorphous layer, the excess vacancies can condense to form the observed banded distribution of voids. In the as-implanted sample associated with the former case, a continuous amorphous GaAs layer did not form, and therefore, upon annealing, voids are seen throughout the implanted region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.349669
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  • 5
    Electronic Resource
    Electronic Resource
    Photoluminescence and electro-optic properties of small (25–35 nm diameter) quantum boxes (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 62 (1993), S. 2766-2768 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The luminescence and electro-optic properties of buried 25–35 nm quantum boxes have been measured. The quantum boxes were defined by a combination of molecular beam epitaxial growth and regrowth, electron beam lithography, and dry etching. The photoluminescence from 35 nm boxes shows a blue shift of ∼15 meV compared to the bulk luminescence and an enhancement, taking into account the fill factor. An enhanced effective linear electro-optic coefficient, rl, is observed for the quantum boxes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.109254
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  • 6
    Electronic Resource
    Electronic Resource
    Systematic variation in myosin expression along extraocular muscle fibres of the adult rat (1990)
    Springer
    Journal of muscle research and cell motility 11 (1990), S. 25-40 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Monoclonal antibodies (McAB) specific for fast (C14) and slow (S58) myosin, and a myosin antigenically similar to neonatal/embryonic myosin in mammals (ALD180), were used to characterize the myosin distribution in orbital layer fibres of rat extraocular muscles (EOM) in relation to innervation patterns. The orbital layer is composed of both singly-innervated (SIF) and multiply-innervated (MIF) fibres. The SIFs have the characteristics of twitch fibres, while the MIFs, in addition to possessing many small endings characteristic of tonic fibres, also have an en-plaque-like innervation in the endplate band resembling that of the adjacent SIFs. Myosin expression in MIFs and SIFs is unusual and varies systematically along the length of the fibres. Both SIFs and MIFs label with ALD180, but this labelling is absent in both fibre types in the endplate band region, where all fibres label with C14. Distally and also proximally to the endplate band, SIFs label with both ALD180 and C14, while the MIFs, innervated by many small, superficial endings in these regions, label with ALD180 only. This pattern of myosin expression could also be demonstrated in isolated fibres. The results are discussed in relation to the hypothesis that both populations of orbital layer fibres express constitutively both fast and the neonatal-like myosin, and that superimposed on this constitutive expression twitch or tonic innervation acts locally to selectively suppress either neonatal-like or fast myosin, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01833323
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of alpha-cardiac myosin heavy chain mRNA and protein in extraocular muscle of the adult rabbit (1994)
    Springer
    Journal of muscle research and cell motility 15 (1994), S. 505-515 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Extraocular muscles contain both fast-twitch and multiply-innervated, tonic-contracting fibres. In rat, these fibres collectively express numerous myosin heavy chain isoforms including fast-type embryonic and neonatal, adult slow twitch type I and fast twitch type II, and a fast isoform unique to extraocular muscle. Immunocytochemical and Western blotting results are presented which suggest that, in rabbit, an additional species, the α-cardiac myosin heavy chain, is present. The immunoreactive species is found in all rabbit extraocular muscles and in the rotatory extraocular muscles is expressed in almost all fibres which do not contain a fast myosin heavy chain. Positive identification of this isoform as the α-cardiac myosin heavy chain was obtained by sequencing a cloned PCR product derived from extraocular muscle mRNA unique to the 3′-end of rabbit α-cardiac myosin heavy chain mRNA. This is the first unequivocal demonstration of α-cardiac myosin heavy chain expression in extraocular muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121157
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