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  • 1
    Electronic Resource
    Electronic Resource
    Factors influencing meningioma recurrence rate (1990)
    Springer
    Acta neurochirurgica 107 (1990), S. 108-111 
    Details
    ISSN: 0942-0940
    Keywords: Meningioma recurrence ; malignant meningioma ; histological subtypes ; operation's grade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors studied retrospectively 23 recurrent meningiomas of a total series of 277 intracranial meningiomas operated upon in the Department of Neurosurgery, University of Würzburg, between 1983 and 1989. All tumours were diagnosed by CT scan or MRI and operated upon using modern neurosurgical operation technology such as CUSA, Neodym-YAG-laser and if necessary operating microscope. Age, sex and tumour site could not be demonstrated as an influencing factor of tumour recurrence. Histological subtype and cellular criteria (mitoses, nuclear pleomorphism, focal necrosis) also were not predictive for tumour recurrence in the individual case. We found longer recurrence-free intervals after complete tumour removal (Simpson's grade I or II) than after subtotal tumour excision (Simpson's grade III or IV), but this tendency was not statistically significant. Obviously the analysed factors especially histomorphological criteria and surgical grading do not reflect the total biological behaviour of recurrent meningiomas. Further studies on growth kinetics and tumours metabolism may help to solve this problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405788
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Progression of myopathology in Kearns-Sayre syndrome: a morphological follow-up study (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 679-681 
    Details
    ISSN: 1432-0533
    Keywords: Myopathy ; Kearns-Sayre-syndrome ; Cytochrome c oxidase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334681
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sex hormone binding and peritumoural oedema in meningiomas: Is there a correlation? (1992)
    Springer
    Acta neurochirurgica 115 (1992), S. 98-102 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral oedema ; meningioma ; progesterone receptor ; steroid receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Steroid receptor binding activity was evaluated in specimens of 28 human cerebral meningiomas using a dextran coated charcoal (DCC) assay. Oestrogen receptor (ER) binding activity at significant levels (〉 10 fmol/mg protein) could be detected only in three postmenopausal females (11% positive cases) at low levels. Positive progesterone receptor (PR) binding was detected in eighteen of the twenty-eight analysed meningioma tissues (64% positive cases). A significantly higher level of PR in male than in female patients could be demonstrated. The degree of peritumoural oedema could be evaluated from CT scans. There was no significant correlation between lack and amount of peritumoural oedema and quantity of cytosolic PR binding activity. Therefore we conclude, that peritumoural oedema is related to other factors and a possible role of PR activity in development of peritumoural oedema and growth control of meningiomas could not be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406365
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative study of histopathological alterations during intestinal infection of mice with pathogenic and non-pathogenic strains ofYersinia enterocolitica serotype O:8 (1993)
    Springer
    Virchows Archiv 423 (1993), S. 97-103 
    Details
    ISSN: 1432-2307
    Keywords: Yersinia enterocolitica ; Peyer's patches ; Ultrastructure ; M-cell ; Invasiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Yersinia enterocolitica is an invasive pathogen capable of causing a wide spectrum of gastrointestinal diseases in man. While there is a considerable body of data on the invasiveness ofY. enterocolitica in vitro, little is known about the events in vivo leading to the translocation of the bacteria from the intestinal lumen into the ileal tissue. There is no detailed ultrastructural information describing the course of infection of pathogenicY. enterocolitica in comparison with an avirulent strain. We compared a virulent plasmid-bearing strain and an isogenic avirulent plasmid-free derivative strain ofY. enterocolitica serotype O∶8 at the ultrastructural level, in the established model of murine yersiniosis. At 12 h postinoculation we found no indications of an active invasion of the intestinal epithelium, although microcolonies of the pathogenic strain were detectable closely under the follicle-associated epithelium of the Peyer's patches. The plasmid-bearing strain ofY. enterocolitica affected the gut-associated lymphoid tissue which was destroyed 36 h post-infection. Unlike the pathogenic strain ofY. enterocolitica, the nonpathogenic plasmid-free strain caused no detectable morphological alterations in the ileal tissue by this time. Morphological evidence is provided thatYersinia does not invade the ileal epithelium in an active manner, as has been observed in vitro, but appears to be transported across the epithelial barrier by M-cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606583
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    Paper (German National Licenses)
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