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  • 1990-1994  (4)
Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serum IgE antibodies were detected with the radioallergosorbent test (RAST) to a panel of allergens which included Pityrosporum orbiculare, Candida albicans, Trichophyton rubrum, Cladosporium herbarum, Staphylococcus aureus, animal dander, deciduous tree pollens, grass pollens and foods in 81 consecutive patients with total IgE ≥ 3000 kU/1. Data on atopic and infectious disease characteristics were collected by a questionnaire. IgE antibody concentrations to P. orbiculare were significantly higher than to the other fungi and of the same magnitude as those to animal danders and pollens. High levels of P. orbiculare IgE antibodies were associated with current eczema, especially when it was the only atopic manifestation and demanding specialist care. IgE antibodies to P. orbiculare had the best explanatory value for current eczema in logistic regression analysis. Head-neck-face dermatitis was also associated with high levels of specific IgE to the yeast. IgE antibodies to S. aureus were detected in few patients and at low concentrations. Six patients had a history of systemic staphylococcal infections and presented a clinical picture, which was very similar to the hyperimmunoglobulinaemia E syndrome. Among the six were the two cases with the highest levels of IgE antibodies to S. aureus. The demonstration of high levels of IgE antibodies to P. orbiculare, which is a major part of human normal skin microflora, suggests that allergy to this yeast plays an important pathogenic role in eczema.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 1 (1990), S. 0 
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One hundred and thirty-nine children (85 hoys) from a paediatric allergy clinic were included in a study which aimed to relate disease traits of fungal allergy to measured serum IgE antibodies to fungi. A structured case history was recorded and the children were subject to a panel of skin prick tests which included common inhalant allergens and two fungi, Cladosporium herbarum and Alternoria alternata. Serum IgE antibodies to 16 different fungi were assayed by RAST using the Pharmacia extended panel. Forty-seven of the children were positive to fungal RAST and many of them were positive to multiple fungi. C. herbarum gave the highest frequency of positive results. The best combination of three fungi for detecting fungal sensitization was C. Herbarum, Penicillium notatum and Mucor racemosus. Skin prick test (SPT) failed to uncover fungal sensitization in many children with broad RAST sensitivity. Children with RAST positivity to fungi generally had more severe asthma and more frequently recognised summer and autumn to be a difficult period compared with children without such positivity. In stepwise regression analysis, positive SPT for cat had the best explanatory value for asthma and positive C. herbarum RAST the second best. Children with fungal RAST positivities were not over-represented among cases with allergic rhino-conjunctivitis but there was a strong association to eczema. The latter is possibly explained by concomitant sensitization to fungi colonizing the human skin. It is suggested that the identification of fungal allergy in asthmatic children will help ensure that proper anti-inflammatory treatment is instituted during peak spore periods.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 3 (1992), S. 0 
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To examine the association between environmental exposure during the first two years of life and development of atopic disease later in child-hood, 115 children sensitized to airborne allergens and 54 non allergic controls were investigated. Fifty-seven of the atopic children were skin prick test (SPT) positive to house dust mites (HDM). Information on exposure was obtained from questionnaires. Parental allergy was a more important risk factor for development of atopy than any of the environmental risk factors. Exposure during the 2 first yr of life to environmental tobacco smoke (ETS) and home dampness was more frequently found among the HDM-sensitized children than among the controls (OR = 2. 8, CI 1. 0-7. 3 and OR = 4. 6, CI 1. 4-15. 0 respectively). A combination of these two factors seemed to be particularly harmful (OR = 8. 7, CI 2. 3-33. 1). Similar but less pronounced effects were seen for children with other allergies. Later in life exposure both to dampness and ETS was of the same magnitude in the atopic children as in the controls. It appears that exposure to environmental factors during the first few years of life may trigger for development of atopic disease and that interactions may be of particular importance.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Wickman M, Nordvall SL, Pershagen G, Korsgaard J, Johansen N, Sundell J. Mite allergens during 18 months of intervention.In Stockholm, Sweden, 17 children with newly diagnosed sensitization to house-dust mites (HDM) and 11 children with previously diagnosed HDM-sensitization were included in a study of HDM-allergen avoidance. Mattress dust was collected on repeated occasions during 18 months and assayed for concentration of major HDM allergens. During the first 12 months, the parents of the intervention group were instructed to intensify cleaning and airing of the child's bedroom. During the last 6 months of the study, the mattresses and pillows of seven children in the intervention group and sibling controls were encased in semipermeable polyurethane covers. The homes exhibited a high absolute indoor humidity throughout the year, and even during the winter the mean levels exceeded 7 g/kg. No mite allergen reduction was seen in the intervention group during the first year. However, among the newly diagnosed HDM-sensitized children, there was a mean reduction of the mattress mite allergen concentration of 83% (P= 0.02), and this was most pronounced in the homes with low humidity. At the end of the mattress encasement period, an average difference of 98% (P〈 0.001) was found between the vacuumed amount of mite allergen on top of the covers and that underneath.
    Type of Medium: Electronic Resource
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