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  • 1
    ISSN: 1432-0428
    Keywords: Autonomic symptoms ; counterregulatory hormones ; glucose thresholds ; hypoglycaemia ; neuroglycopoenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine healthy subjects were studied on two separate occasions, at least two weeks apart, using the glucose clamp technique to produce a gradual hypoglycaemia. Glucose thresholds for neuroendocrine and symptom responses varied up to 1.5 mmol/l between subjects. There was a significant correlation between individual glucose thresholds on day 1 and 2 for adrenaline (p = 0.0008), growth hormone (p = 0.007) and pancreatic polypeptide (p = 0.02), and for autonomic (p = 0.018) and neuroglycopoenic (p = 0.023) symptoms, whereas no significant correlations were found for glucagon and cortisol. The mean intra-individual differences in glucose thresholds between day 1 and 2 were 0.22 mmol/l for the hormones and 0.25 mmol/l for the symptoms. We conclude that healthy subjects differ in hypoglycaemic thresholds, and that the difference reflects individual variation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 43 (1992), S. 265-268 
    ISSN: 1432-1041
    Keywords: Diabetes mellitus ; Drug protein binding ; Catecholamines ; adrenoceptor blockers ; prazosin ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In the present study equilibrium dialysis has been used to determine the degree of protein binding of the catecholamines adrenaline and noradrenalin and the adrenergic receptor blockers, prazosin and propranolol in diabetics. The binding of the catecholamines in plasma from Type I and II diabetic patients was not significantly different from that of healthy subjects. The ratio of the bound and free catecholamine concentrations was correlated with the level of albumin (HSA). Significantly reduced protein binding of prazosin was observed in Type I and II diabetic subjects compared to healthy volunteers. The binding of propranolol was significantly reduced in Type I patients. The ratios between the bound and unbound concentrations of prazosin and propranolol were significantly correlated with the levels of a,-acid glycoprotein (AAG). The results suggest that non-enzymatic glycosylation of plasma proteins may increase the unbound fraction of the adrenergic blockers prazosin and propranolol.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 43 (1992), S. 109-111 
    ISSN: 1432-1041
    Keywords: Lidocaine ; Platelet function ; beta-thromboglobulin ; thromboxane A2 ; catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of therapeutic plasma concentrations of lidocaine on blood platelet function and plasma catecholamine levels were assessed in 9 healthy subjects. There were no significant effects on plasma levels ofβ-thromboglobulin, collagen and adenosine diphosphate-stimulated platelet aggregation, thromboxane-B2-concentration in plasma after collagen and ADP stimulated platelet aggregation, or on plasma nor-adrenaline and adrenaline. No significant correlation could be demonstrated between any of the variables tested. Thus, it appeared that lidocaine had no effect on platelets that could be of benefit in acute myocardial infarction. It should be possible to use lidocaine, in combination with thrombolytic therapies without increasing the risk of bleeding complications.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Experiments to explore the long-time evolution of noninductive, high βp plasmas in the DIII-D tokamak [Plasma Physics and Controlled Nuclear Fusion Research, 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 159], have identified a new, quiescent, high performance regime. The experiments were carried out at low current (400–800 kA) with medium power neutral beam injection (3–10 MW). This regime is characterized by high q0 ((approximately-greater-than)2) and moderate li(∼1.3). It is reached by slow relaxation of the current profile, on the resistive time scale. As the profiles relax, q0 rises and li falls. When q0 goes above 2 (approximately), magnetohydrodynamic (MHD) activity disappears, and the stored energy rises. Most dramatic is the strong peaking of the central density, which increases by as much as a factor of 2. The improved central confinement appears similar to the PEP/reversed central shear/second stable core modes seen in tokamak experiments, but in this case without external intervention or transient excitation. At high current, a similar, but slower relaxation is seen. Also notable in connection with these discharges is the behavior of the edge and scrape-off layer (SOL). The edge localized modes (ELM's) as seen previously, are small and very rapid (to 1 kHz). The SOL exhibits high density (≥1×1019 m−3), which shows little or no falloff with radius. Also the power deposition at the divertor surface is very broad, up to four times the width usually seen. This regime is of particular interest for the development of steady-state tokamak operating scenarios, for the Tokamak Physics Experiment (TPX), and following reactors.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anatomia, histologia, embryologia 19 (1990), S. 0 
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The capillarization of the M. pectoralis of the Turkey (Meleagris gallopavo) from birth do day 280The capillarization of the M. pectoralis was examined in the turkey as it changed with age. Examined was the density of the muscles fibers (per mm2), the density of the capillaries (per mm2) and the quotient muscle fibers/capillaries. In accordance with the sequence of the original data four functions of organismic growth (slightly altered) were utilized for the approximation of the data for descending amounts: Pütter/Bertalanffy (1920, 1934); Richards (1959; Janoschek enlarged after Sager (1980 and Richards enlarged after Sager (1980). The approximations were made via nonlinear regressions, whereby the sum of the error amounts and the sums of teh error squares served as criteria of quality. The results including the deduced initial and end amounts are combined in tables which also contain the parameter of the way the computations were conducted.
    Type of Medium: Electronic Resource
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