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  • 1
    Electronic Resource
    Electronic Resource
    Extensive demyelinating changes in the peripheral nerves of Crow-Fukase syndrome: a pathological study of one autopsied case (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 171-177 
    Details
    ISSN: 1432-0533
    Keywords: Crow-Fukase syndrome ; Segmental demyelination ; Excessive myelin outfold ; Focal T cell infiltrates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pathological changes of the peripheral nervous system in one autopsied case of Crow-Fukase syndrome (POEMS syndrome) was systemically examined. Distally accentuated myelinated axon loss was observed in the peripheral nerve trunks, ventral and dorsal spinal roots, but was not observed in the fasciculus gracilis. Segmental demyelination and remyelination associated with focal excessive myelin outfolds were the most characteristic features, the distribution of which was more prominent in the proximal nerve trunks and the spinal nerve roots. Endoneurial edema was present, and focal perivascular T lymphocyte accumulation was occasionally observed in the spinal nerve roots and proximal nerve trunks. Neurons in the sympathetic ganglia, dorsal root ganglia and ventral horns were well preserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311391
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 402-408 
    Details
    ISSN: 1432-0533
    Keywords: Phosphorylated high molecular weight neurofilament ; Motor neuron ; Amyotrophic lateral sclerosis (ALS) ; Werdnig-Hoffmann's disease ; X-linked recessive bulbospinal neuronopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lower motor neurons of the spinal cord of patients with amyotrophic lateral sclerosis (ALS), Werdnig-Hoffmann's disease (WH), X-linked recessive bulbospinal neuronopathy (X-BSNP) and multiple system atrophy (MSA), all of which were known to involve the lower motor neurons, were immunohistochemically examined by using a monoclonal antibody (Ta-51) specific to phosphorylated epitopes of high molecular weight subunits of neurofilaments. The incidence of Ta-51-positive neurons was significantly increased in ALS, WH and MSA, but not in X-BSNP. Ta-51-positive neurons showed a wide variety of morphological appearances, including neurons with normal appearance, central chromatolysis, simple atrophy and neurons containing massive neurofilamentous accumulation. In aged-control cases, similar Ta-51-positive neurons were observed, although to a much lesser extent. In ALS, spheroids and globules, which were strongly positive for Ta-51, were also significantly increased. Ta-51-positive motor neurons, spheroids and globules appeared in proportional to the number of remaining large motor neurons in ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308716
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: system-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 240-245 
    Details
    ISSN: 1432-0533
    Keywords: High molecular weight neurofilament ; Phosphorylation ; Peripheral nervous system ; Amyotrophic lateral sclerosis ; Multiple system atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using monoclonal antibody (Ta-51) that specifically binds phosphorylated high molecular weight neurofilament (pNFH) proteins, we investigated the occurrence of perikaryal pNFH in the spinal ventral horn motoneurons, intermediolateral column (ILC) neurons, sympathetic ganglion neurons and dorsal root ganglion (DRG) neurons obtained from patients with amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA) and from control cases. In the controls, a system-dependent variation in perikaryal Ta-51 immunoreactivity was observed. Very few ventral horn cells and ILC neurons were stained with Ta-51, while large population of DRG neurons and sympathetic neurons were Ta-51 positive. The incidence of perikaryal immunoreactivity in the ventral horn cells was significantly increased in ALS and MSA. Some ILC neurons in ALS were Ta-51 positive and their incidence was significantly higher than that of the controls. These data suggest that both ILC neurons and ventral horn cells are affected with respect to pNFH metabolism in ALS and MSA. No significant difference was, however, detected in the Ta-51 immunoreactivity of both DRG and sympathetic ganglion neurons in ALS and MSA as compared with the controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296785
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Age-related changes of the myelinated fibers in the human corticospinal tract: a quantitative analysis (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 137-142 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Corticospinal tract ; Myelinated fibers ; Axon-collaterals ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A quantitative analysis was made of the myelinated fibers in the lateral corticospinal tract (LCST) at the levels of the 6th cervical, 7th thoracic and 4th lumbar spinal segments in 20 patients between 19 and 90 years old, and who died of non-neurological diseases. The diameter frequency histograms of myelinated fibers of LCST showed a bimodal pattern with a sharp peak of the small myelinated fibers and broad slope of the large myelinated fibers. The ratio of small fiber to large fiber densities was significantly higher in the 6th cervical (P 〈 0.05) and 4th lumbar segments (P 〈 0.01) than in the 7th thoracic segments. The density of small myelinated fibers was significantly lowered with advancing age (P 〈 0.05 ∼ 0.001), while that of large myelinated fibers was not significantly decreased in the aged patients, although it showed a slight age-dependent declining tendency. Age-dependent decline of small fiber density was more prominent in the cervical and lumbar segments. Retraction of the axon-collaterals from large-diameter myelinated fibers, which are abundant in the cervical and lumbar segments, may contribute to the age-related diminution of the small myelinated fibers in the LCST.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294506
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    Paper (German National Licenses)
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