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  • 1
    Electronic Resource
    Electronic Resource
    Cystic islet cell tumors: Radiologic findings in three cases (1994)
    Springer
    Abdominal imaging 19 (1994), S. 225-228 
    Details
    ISSN: 1432-0509
    Keywords: Pancreas, neoplasms ; Islet cell tumors, diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report three cases of cystic islet cell tumors, two caused by gastrinomas and the other by an islet cell carcinoma. All three patients underwent computed tomography (CT) and angiography and two also had magnetic resonance (MR) imaging. Several common radiographic findings were present as follows: thickening of the cyst wall and irregularity of the inner surface on postcontrast CT and MR images, neovascularity and a densely staining hypervascular rim on angiography, and moderately increased signal intensity of the cyst content on T1-weighted MR images, which indicated fluid containing blood and/or necrotic tissue. These findings are helpful in defining the nature of these lesions and strongly suggest that cystic islet cell tumor should be included in the differential diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203512
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stimulation of human fetal astrocyte proliferation by bacterial lipopolysaccharides and lipid A (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 384-388 
    Details
    ISSN: 1432-0533
    Keywords: Bacterial endotoxin ; Lipopolysaccharide ; Lipid A ; Culture astrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1 μg/ml LPS or lipd A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [3H]thymidine incorporation. These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296549
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lysosomal glycosphingolipid storage in chloroquine-induced α-galactosidase-deficient human endothelial cells with transformation by simian virus 40: in vitro model of Fabry disease (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 272-279 
    Details
    ISSN: 1432-0533
    Keywords: Fabry disease ; Endothelial cells culture ; Simian virus 40 ; Transformation ; Chloroquine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human umbilical venous endothelial cells were transformed with a temperature-sensitive mutant of simian virus 40, tsA640, and a cell line, subcultured for over 20 serial passages, was established at a temperature permissive for the virus. Treatment of transformed endothelium with 3μg/ml chloroquine caused a specific reduction of α-glactosidase activity, without cell injury, and revealed several electron-dense materials surrounded by single unit membranes. Crystalline lamellae in lysosomes with a periodicity of 6.5 nm, which are typically seen in various tissues in Fabry disease, were produced in the presence of a glycosphingolipid mixture. These cells should be useful for in vitro pathophysiological studies on Fabry endothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227722
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Suppression of pulmonary granulomatous inflammation by immunomodulating agents (1992)
    Springer
    Inflammation research 37 (1992), S. 99-106 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We demonstrated previously that macrophages and macrophage-derived cytokines including lymphocyteactivating factors (LAFs) play a critical role in lung granuloma formation in mice and that granulomas sizes correlated with LAF activity in the lesions. In the present study, we examined the effects ofd-penicillamine (d-Pc), 2-acetylthiomethyl-3-(4-methyl-benzoyl)propionic acid (KE-298) and dexamethasone (Dex) on dextran bead-induced lung granulomas in mice. KE-298 is a newly synthesized compound containing sulfur (S) similar tod-Pc. Large granulomas developed, which reached peak intensity within 3 days and declined in size thereafter. Aqueous lung extracts of the mice contained high levels of LAF that were correlated with granuloma sizes. The lesions and local LAF activity were inhibited by administration of these agents. The most potent inhibitor was Dex. The suppressive effect of KE-298 was similar to that ofd-Pc. These results suggest that suppression of granulomas may be attributed to inhibition of LAF activity/synthesis by these agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01987896
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Endoscopic evaluation of gastric cancer infiltrating the lower esophagus (1992)
    Springer
    Surgical endoscopy and other interventional techniques 6 (1992), S. 62-67 
    Details
    ISSN: 1432-2218
    Keywords: Esophageal infiltration ; Cancer of upper third of stomach ; Cardiac cancer ; Preoperative examination of frozen section
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endoscopic and histopathological findings were compared in 74 patients with gastric cancer infiltrating the lower esophagus who had undergone gastrectomy to evaluate mode of esophageal infiltration. There were no early cancers. Cancer infiltration modes were histopathologically broken down into three types: superficial, whole layer, and deep layer. Endoscopic findings were broken down into five types for proximal infiltration. Endoseopy used for histological evaluation frequently revealed the protruded type to be whole layer and had a highly accurate diagnosis rate (94%); it revealed the histology of the other four types to be primarily superficial. Extent of cancer invasion was underestimated in giant-rugae tumors (40%), as endoseopy could barely detect the small nest of esophageal infiltrations. Lugol staining was useful in preventing underestimation. For flat cancer, which is poorly demarcated and is often accompanied by vascular invasion, preoperative evaluation is very difficult, requiring preoperative examination of a frozen section taken from the proximal edge of resected specimen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02281082
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A balloon-tipped liver lobe retractor (1994)
    Springer
    Surgical endoscopy and other interventional techniques 8 (1994), S. 140-140 
    Details
    ISSN: 1432-2218
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316628
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Intracranial calcification in siblings with nephrogenic diabetes insipidus: CT and MRI (1993)
    Springer
    Neuroradiology 35 (1993), S. 553-555 
    Details
    ISSN: 1432-1920
    Keywords: Nephrogenic diabetes insipidus ; Intracranial calcification ; Brain damage ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Computed tomography and magnetic resonance imaging (MRI) were used to examine three male siblings with nephrogenic diabetes insipidus (NDI). The two elder brothers had verying degrees of unusual intracranial calcification; the eldest also showed involvement of the cerebral white matter on MRI. The severity of intracranial calcification was related to the time before initiation of treatment and inversely to mental ability. Brain damage and mental retardation in NDI may be caused by a delay in initiating treatment; early detection and treatment are important to prevent brain damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588723
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  • 8
    Electronic Resource
    Electronic Resource
    MR imaging of spastic diplegia (1990)
    Springer
    Neuroradiology 32 (1990), S. 187-190 
    Details
    ISSN: 1432-1920
    Keywords: Spastic diplegia ; Periventricular leukomalacia ; MRI ; Preterm infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighteen children (eleven preterm birth and seven term birth) with clinical evidence of spastic diplegia (SD) were studied to clarify the differences of the lesions between preterm and term SD on MR imaging. All with preterm birth showed similar abnormalities of the periventricular white matter represented by high intensity in T2-weighted imaging and low intensity in T1 imaging. It seemed that the lesions were periventricular leukomalacia (PVL) and dysmyelination pathologically and correlated well clinically with spastic diplegia. SD with term birth group showed various lesions, two brain anomalies (schizencephaly and corpocephaly), one PVL, four showed no lesions. We suggested that SD with preterm birth is not only a clinical but also a pathological entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589108
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Single-port laparoscopy assisted appendectomy under local pneumoperitoneum condition (1994)
    Springer
    Surgical endoscopy and other interventional techniques 8 (1994), S. 714-716 
    Details
    ISSN: 1432-2218
    Keywords: Laparoscopic appendectomy ; Single-port laparoscope-assisted appendectomy ; Local pneumoperitoneum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe herein a novel, simplified technique of laparoscope-assisted appendectomy under local pneumoperitoneum condition. A 12-mm-outer-diameter laparoscope fitted with a transparent plastic cap is inserted through a single, small, open laparotomy incision. This scope has a 5-mm working channel for insertion of the multifunctional metallic catheter which maintains the local pneumoperitoneum condition. When we have located the inflamed appendix by tracing the tenia of cecum, we use the grasping forceps protruding from the working channel of this laparoscope to grasp its tip or root on the cecum. This allows us to pull the appendix up and out through the small incision and to resect it in the conventional surgical way. This procedure permits the surgeon to perform appendectomy by making only one small incision under spinal anesthesia, and also eliminates development of the intracavitary concomitant diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00678574
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    Paper (German National Licenses)
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