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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 9 (1993), S. 3085-3092 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 25 (1992), S. 6775-6783 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The N1303K mutation was identified in the second nucleotide binding fold of the cystic fibrosis (CF) gene last year. We have gathered data from laboratories throughout Europe and the United States of America in order to estimate its frequency and to attempt to characterise the clinical manifestations of this mutation. N1303K, identified on 216 of nearly 15000 CF chromosomes tested, accounts for 1.5% of all CF chromosomes. The frequency of the N1303K allele varies significantly between countries and ethnic groups, being more common in Southern than in Northern Europe. This variation is independent of the AF508 allele. It was not found on UK Asian, American Black or Australian chromosomes. N1303K is associated with four different linked marker haplotypes for the polymorphic markers XV-2c, KM.19 and pMP6d-9. Ten patients are homozygous for this mutation, whereas 106 of the remainder carry one of 12 known CF mutations in the other CF allele. We classify N1303K as a “severe” mutation with respect to the pancreas, but can find no correlation between this mutation, in either the homozygous or heterozygous state, and the severity of lung disease.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 2704-2714 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The results of canonical ensemble molecular dynamics calculations of mixtures of Lennard–Jones and Stockmayer fluids are reported. To study solely the influence of the polarity, the Lennard-Jones parameters were identical for both components. The excess mixing properties show a strong asymmetry with respect to composition for large dipolar strength. The free energy of mixing is obtained through a thermodynamic integration procedure. The results strongly suggest that, for reduced dipolar strengths μ2〉3.15, demixing occurs into a phase rich in polar component and an almost pure Lennard-Jones fluid. It is shown that perturbation theory yields fairly accurate results for the dipolar energy and free energy of the mixture. For the free energy of mixing, qualitatively correct results are obtained. The structure and orientational correlation functions of the mixture are discussed. The radial distribution function for pairs of polar molecules show a marked increase in local ordering with dipolar strength for low concentrations of the polar component, indicating that strong clustering of polar molecules occurs at these concentrations. The orientational order is also seen to increase very strongly with dipole moment at these concentrations. The pair correlation function for pairs of Lennard-Jones atoms shows little dependence on dipolar strength of Stockmayer molecules at these concentrations. The distribution function for pairs of unlike molecules reflects the increasingly dissimilar character of these molecules as the dipolar strength increases. For large concentrations of Stockmayer molecules, the opposite effect is observed, albeit less pronounced, in that the pair-correlation function for Lennard-Jones atoms shows an increase in local ordering as μ increases, whereas the radial distribution function for Stockmayer pairs remains relatively unaffected with increasing μ. These results are interpreted in terms of a frustation model. Results are given for the variation of the dielectric constant of the mixture with composition and dipolar strength.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate the use of a digital imaging system for colposcopy, its use for image analysis and quantification of the colposcopic features that may predict histological outcome as defined by large loop excision of transformation zone.Design Prospective programme study of all patients undergoing colposcopy for cytological abnormalities.Setting Dudley Road Hospital, Birmingham.Subject Fifty consecutive patients having cytological and colposcopic abnormality treated with large loop excision of transformation zone formed the study group.Main outcome measures Pretreatment and colposcopic features correlated with histological diagnosis of excised transformation zone.Results Index cytology and current smoking status are the most important variables for prediction of histological diagnosis. Other important variables are focality of lesion, surface pattern, intercapillary distance and degree of acetowhiteness.Conclusion Digital imaging colposcopy allows image capture, processing and objective analysis. This methodology holds advantages for basic and clinical research, teaching, diagnostics and clinical audit. The system can act as a quality control tool for colposcopy units. This system should prove invaluable for further quantitative studies, for natural history studies and for those patients with deferred treatment of their cytological and colposcopic abnormalities. The statistical models described may be incorporated into the system and can aid the colposcopist in management of the woman with abnormal cervical cytology and colposcopic abnormality.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 8277-8289 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report a systematic analysis of the crystal-field spectra of four fluoride compounds containing tetravalent actinide ions. The first part of this work [J. Chem. Phys. 95, 7194 (1991)] provided interpretation of the absorption spectra of UF4, NpF4, and PuF4. To extend our analysis to heavier elements of the series, low-temperature absorption spectra of AmF4 and CmF4, and site selective laser-induced emission and excitation spectra of Cm4+:CeF4 and Bk4+:CeF4 were obtained. A model energy level calculation was found to be in good agreement with the experimental results. It is shown that the crystal-field interaction in combination with spin–orbital coupling results in significant J mixing in the excited states, but ground state wave functions are still relatively pure in J character for the tetravalent actinide ions Am4+, Cm4+, and Bk4+. Trends in the parameters of the effective operator Hamiltonian are compared with those of a Hartree–Fock free-ion model. Interpretation of the ground-state splitting of the nominal S-state ion Bk4+ in CeF4 and color center formation in AmF4 are also discussed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 95 (1991), S. 7194-7203 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: An interpretation of the low-temperature absorption spectra of AnF4 (An=U, Np, Pu) is presented. Using an effective operator Hamiltonian with orthogonalized free-ion operators and initializing crystal-field parameter values based on a superposition model calculation for An4+ sites with C2 symmetry, good agreement between the model calculations and experimentally observed absorption band structure could be obtained. Correlations with published magnetic and heat capacity measurements are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 14 (1993), S. 545-584 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Since modern high frequency device technology is shifting towards planar miniaturization, ferrite films will play an important role in facilitating the design and fabrication nonreciprocal monolithic integrated devices such as isolators and circulators. The authors have examined magnetic and structural properties for a series of pulsed laser deposited (PDL) single crystal MnZn-ferrite films. The films were epitaxially grown on (001) MgO at substrate temperatures of 300 °C, 400 °C, 600 °C, and 800 °C in an oxygen partial pressure of 30 mTorr. The film microstructure, crystal structure, and composition were characterized by SEM, x-ray diffraction and atomic absorption spectroscopy, respectively. The magnetocrystalline anisotropy constant K1, uniaxial anisotropy constant Ku, saturation magnetization Ms, and coercive force Hc were examined by torque and vibrating sample magnetometry. Ferrimagnetic resonance measurements were made on the films to obtain the linewidth ΔH. A comparison of the magnetic, structural, and chemical properties shows that K1 and Ms scale with the Fe2+ ion concentration and that Ku, Ms, and ΔH are very sensitive to the microstructure. The values of K1, Ms, and ΔH obtained for films deposited at 800 °C were compared with those of bulk MnZn-ferrite and found to exceed the bulk values (Table I), thus making PLD ferrite films very attractive for nonreciprocal device applications.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 11652-11656 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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