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  • 1
    Electronic Resource
    Electronic Resource
    Mandibular deformities in parathyroid hormone-related protein (PTHrP) deficient mice: possible involvement of masseter muscle (2000)
    Springer
    Anatomy and embryology 202 (2000), S. 85-93 
    Details
    ISSN: 1432-0568
    Keywords: Key words Intramembranous ossification ; Immunohistochemistry ; Muscle fiber type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies using parathyroid hormone-related protein (PTHrP) null mutant mice have indicated severe abnormalities in the endochondral ossification, suggesting that PTHrP affects chondrocyte differentiation. In this study, we found in newborn PTHrP-deficient mice some deformities in the mandible that is formed via intramembranous ossification. The mandibular ramus was bent downwards and a prominent bone crest to which the deep layer of masseter muscle was tendinously attached was observed in the mandibular body. Transmission electron microscopic studies showed that active bone formation was progressing along the tendon fibers of the masseter muscle. The examination of 3-D reconstruction models indicated that the mandibular ramus was bent at the site of muscle attachment, which was shifted in the direction of the muscle fibers. Muscle fiber type analysis using myosin ATPase staining showed that the masseter muscle in the newborn PTHrP-deficient mice contained numerous type 2B fibers, demonstrating premature maturation of this muscle. Based on these findings, we speculated that premature maturation of the masseter muscle leads, probably due to increased tensile forces, to accelerated bone crest formation and subsequent bending of the mandibular ramus. These results further suggest that PTHrP is involved in the regulation of muscle development in normal animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004290000100
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  • 2
    Electronic Resource
    Electronic Resource
    Serum from pregnant women carrying a fetus with neural tube defect is teratogenic for rat embryos in culture (1989)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Sera from 13 pregnant women carrying a fetus with a neural tube defect, and from 13 control women with normal pregnancies at the same stage of gestation were used in the culture of postimplantation rat embryos. Serum from women with normal pregnancies had no adverse effect on rat embryo growth and development. Serum from 10 of the women with affected fetuses had a deleterious effect on the rat embryos as abnormalities of neural tube closure were observed in 28% of the conceptuses compared to only 1·3% of the embryos cultured in control scrum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1989.tb01573.x
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  • 3
    Electronic Resource
    Electronic Resource
    On the mystery of the golden angle in phyllotaxis (2004)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 27 (2004), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Phyllotaxis, the arrangement of leaves around a stem, shows in the vast majority of cases a regularity in the divergence angle of subsequent leaves which divide the whole circle into regular fractions. These are in most cases rational fractions of two Fibonacci numbers in an alternating series, converging towards the irrational limit of the golden section, corresponding to the golden divergence angle of 137.5  . . . degrees. This peculiarity was a long-standing mystery. Here, it is related to the evolutionary pressure of optimal light capture for maximal photosynthetic activity. A model is established which relates minimal shadowing for the lower leaves to the divergence angle. Numerical results of this model agree well with semi-empirical data on the dependence of light capture from the divergence angle. The basic shadow function of the model is also related with the demand of minimal shadowing for the angular separation of leaves and obtain, using elementary number theory, as solution the golden section. Further numerical studies show that the rational approach to the golden section (Schimper–Braun series) is related to the leaf width and the number of leaves of the plant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.2004.01185.x
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  • 4
    Electronic Resource
    Electronic Resource
    Prevalence of fluconazole-resistant strains of Candida albicans in otherwise healthy outpatients (2002)
    Oxford, UK : Blackwell Science, Ltd
    Journal of oral pathology & medicine 31 (2002), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  In contrast to the immunosupressed patient population, the prevalence of fluconazole-resistant strains of Candida albicans among healthy individuals has not been extensively studied.Methods:  Candida species were cultured form 50 healthy outpatients with clinical signs of oral candidiasis. Following one week of the recommended fluconazole regimen, post-treatment cultures were obtained. Both pre- and post-treatment yeasts were identified and in vitro susceptibility testing was performed using the NCCLS M-27A method. Strains were further differentiated using established cDNA probes.Results:  Forty-four patients (88%) had positive C.albicans cultures prior to treatment. Antifungal susceptibility testing of these strains demonstrated no in vitro resistance to fluconazole. At post-treatment evaluation, eight patients (18%) had persistent signs of infection and 10 patients (23%) had positive Candida sp. cultures despite no clinical signs of infection. DNA analysis confirmed that the same C. albicans strain was present both in the pre-treatment and the post-treatment cultures.Conclusions:  Our results showed that the presence of fluconazole-resistant strains of C.albicans does not appear to be prevalent among healthy outpatients furthermore, in vitro antifungal susceptibility testing does not always predict successful therapy in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0714.2002.310207.x
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  • 5
    Electronic Resource
    Electronic Resource
    Resolution of candidal lesions of the dorsal rat tongue by ketoconazole (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to determine whether the mucosal alterations of the dorsal rat tongue produced by Candida albicans infection were reversible upon treatment with the antifungal drug ketoconazole. Following experimentally-produced infection, 17 rats showed clinical evidence of persistent lesions over a period of 20 weeks. Eight of these animals were then treated with ketoconazole daily for 2 weeks (20 mg/kg/day). Appropriate non-infected controls and ketoconazole-only controls were also maintained. Five weeks after the ketoconazole treatment, all animals were killed and the dorsal tongues evaluated clinically and histologically. Control groups showed no abnormalities. Of the 8 animals in the treated-lesion group, all showed lesional resolution, while only 2 of the 9 animals in the untreated-lesion group showed resolution of their lesions (p=0.002). These findings indicate that the epithelial changes produced by this candidal isolate for this period of time are reversible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1988.tb01517.x
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  • 6
    Electronic Resource
    Electronic Resource
    Differences in mucosal reaction related to Candida albicans isolates (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 16 (1987), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to examine the behavior of Candida albicans in an oral mucosal model, 16 isolates of the organism were collected from a variety of clinical settings and were inoculated weekly, in equal numbers and concentrations, into the mouths of separate groups of 20 female Sprague-Dawley rats. Oral swabs were taken bi-weekly in order to monitor the presence of the yeast. After 16 weeks, the animals were killed and the tongues were examined grossly and histologically. Six isolates demonstrated the ability to produce characteristic dorsal tongue lesions to varying degrees (1/20; 1/20; 1/20; 2/20; 3/20; and 12/20). Of the remaining 10 isolates, 5 showed hyphal penetration of the keratin layer of the dorsal tongue epithelium, yet no mucosal reaction was elicited and no lesion was produced (1/19; 2/19; 4/20; 5/20 and 5/20). These findings support the concept that C. albicans exhibits a spectrum of mucosal pathogenicity for dorsal rat tongue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1987.tb00693.x
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  • 7
    Electronic Resource
    Electronic Resource
    Closure of a large nasal septal perforation with a lined nasolabial flap (1985)
    Springer
    European journal of plastic surgery 8 (1985), S. 61-65 
    Details
    ISSN: 1435-0130
    Keywords: Septum perforation ; Nasolabial flap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors present a technique of a lined nasolabial flap for closure of a large nasal septal perforation. This is illustrated with a case report. The etiology and symptoms of septum perforations are reviewed and the most common surgical techniques for closure are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264839
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  • 8
    Electronic Resource
    Electronic Resource
    Superdeformed nuclear matter in nuclei with $Z \ge 82$ : Magnetic properties and neutron shell gap (2003)
    Springer
    The European physical journal 20 (2003), S. 31-32 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We report the results of an experiment, realized with the EUROBALL IV spectrometer, in which superdeformed (SD) states have been populated in 197,198Pb nuclei. Crosstalk transitions between two signature partner SD bands in 197Pb have been observed with an established M1 character, giving access to the magnetic properties of the $\nu$ [752]5/2 intruder orbital. Six new SD bands have been identified in 197,198Pb. The results are interpreted in the framework of cranked Hartree-Fock calculations. A mixing between quasi-particle excitations and an octupole vibration is suggested in the two SD isotopes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/i2002-10314-3
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  • 9
    Electronic Resource
    Electronic Resource
    An alternative gamma tracking method using the Compton scattering probability (2003)
    Springer
    The European physical journal 20 (2003), S. 203-204 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. A new gamma tracking method, called probabilistic method and based on the Compton scattering probability of photons in a highly segmented Ge spectrometer, has been evaluated with the GEANT simulation code. This method has been used to calculate the performances of a 4 $\pi$ array composed of planar detectors as their crystal shape allows to realize identical segments of quasi-cubic shape. The tracking algorithm selects the full-absorption events by taking into account only the centre of gravity of the segments hit and the partial energies released in each of them. The results obtained, in terms of photopeak detection efficiency and peak-to-total ratio, are comparable to the ones deduced from the usual tracking methods. The probabilistic algorithm seems also to apply efficiently for other types of detectors as simulation calculations performed on a single stack of planar detector and a single segmented CLOVER detector give nearly the same reconstruction efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/i2002-10354-7
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of acute metabolic acidosis on transmembrane electrolyte gradients in individual renal tubule cells (1988)
    Springer
    Pflügers Archiv 412 (1988), S. 427-433 
    Details
    ISSN: 1432-2013
    Keywords: Acute metabolic acidosis ; Renal distal electrolyte transport ; Renal cell electrolyte concentrations ; Individual distal tubule cells ; Transmembrane electrolyte concentration gradients ; Electron microprobe analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the effect of acute metabolic acidosis on potassium, sodium and chloride gradients across the apical membrane of proximal and distal tubule cells by determining electrolyte concentrations in individual cells and in tubule fluid employing electron microprobe analysis. Cellular measurements were performed on freeze-dried cryosections of the renal cortex, analysis of tubule fluid electrolyte concentrations on freeze-dried microdroplets of micropuncture samples obtained from proximal and from early and late distal collection sites. Acidosis (NH4Cl i.v. and i.g.) induced a substantial rise in plasma potassium concentration without significant effects on cell potassium concentrations. Potassium concentrations along the surface distal tubule were also unaltered; thus the chemical driving force for potassium exit from cell to lumen was not affected by acidosis. In all but intercalated cells acidosis markedly increased cell phosphorus concentration and cell dry weight indicating cell shrinkage and thus diminution of cell potassium content. Because the increase in intracellular chloride concentration exceeded the increase in plasma chloride concentration, the chemical chloride gradient across the contraluminal membrane was markedly depressed by acidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907563
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