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  • 1990-1994  (1)
  • 1985-1989  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Carcinoembryonic antigen expression and peanut agglutinin binding in primary breast cancer and lymph node metastases; lack of correlation with clinical, histopathological, biochemical and morphometric features (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 9 (1985), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a group of 335 patients with primary breast carcinoma the presence of immunoreactive carcinoembryonic antigen (CEA) and the binding of the lectin peanut agglutinin (PNA) in the primary carcinoma and in axillary lymph node metastases were investigated. The correlation between these results and a variety of established clinical, histopathologic, morphometric and biochemical prognosticators was studied. These features included lymph node status, tumour diameter, tumour type, nuclear grade, histologic grade, oestrogen receptor status, mitotic activity index and a number of nuclear measurements. The results indicate that CEA immunoreactivity of and PNA binding to tumour cells in primary breast carcinomas or lymph node metastases do not correlate with established prognostic factors in breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1985.tb02784.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rheumatoid factors in rheumatoid arthritis and vasculitis (1985)
    Springer
    Rheumatology international 5 (1985), S. 209-214 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid factors ; ELISA ; Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study the occurrence of rheumatoid factors (RF) in relation to the activity of rheumatoid arthritis and the occurrence of vasculitis, RF of IgM, IgA, and IgG classes were measured in sera from 35 patients with definite or classic rheumatoid arthritis (RA) using ELISA. For 26 patients, the RF levels were studied longitudinally and compared with changes in the articular index. Although IgM RF was occasionally found in patients without RA, IgA and/or IgG RF were almost exclusively associated with RA. The titers of IgM, IgA, and IgG RF were significantly higher in sera from patients with clinically diagnosed rheumatoid vasculitis than in sera from patients without vasculitis. No significant correlation between changes in the articular index and changes in titer of any class-specific RF could be found for the group of RA patients as a whole. However, in individual patients, increases or decreases in IgM and IgG RF titer were significantly correlated with an increase or decrease in the articular index.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541338
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Detection ofChlamydia trachomatis in clinical specimens by the polymerase chain reaction (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 864-868 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sequences derived from the endogenous plasmid ofChlamydia trachomatis and from the genes coding for ribosomal 16S RNA ofChlamydia psittaci were used as primers and oligonucleotide probes for detection of chlamydiae by the polymerase chain reaction. The endogenous plasmid primers generated specific amplified products of 517 bp with all knownChlamydia trachomatis serovars. No specific products ofChlamydia psittaci andChlamydia pneumoniae could be detected using these primers. With the rRNA primers specific amplified products of 208 bp were generated withChlamydia psittaci, Chlamydia trachomatis andChlamydia pneumoniae. No specific amplified products were detected with DNA isolated from a variety of microorganisms from the urogenital and the respiratory tract. Of 156 clinical specimens used for evaluation of the polymerase chain reaction, 26 were found to be positive forChlamydia trachomatis on culture. All 26 culture positive samples were also found to be positive forChalmydia trachomatis DNA by the polymerase chain reaction with both primer sets. Two culture negative samples were also found to be positive by this technique. The polymerase chain reaction thus seems to be a sensitive and reliable method for detection ofChlamydia trachomatis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967500
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Human serum antibody response inCampylobacter jejuni enteritis as measured by enzyme-linked immunosorbent assay (1988)
    Springer
    European journal of clinical microbiology & infectious diseases 7 (1988), S. 388-393 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An ELISA for detection of IgG, IgA, and IgM antibody using an acid-glycine extract fromCampylobacter jejuni as antigen was developed. To determine the value of this assay for the diagnosis of acuteCampylobacter jejuni infections, the IgG, IgA, and IgM immune response againstCampylobacter jejuni was investigated at various timepoints after infection in patients with culture-proven infection. A total of 112 sera from 46 patients and 78 sera from a control group were tested. All but one of the 46 patients with culture-provenCampylobacter jejuni enteritis developed IgG antibodies againstCampylobacter jejuni. IgA and IgM ELISA both showed 97% specificity, and sensitivity of 63% and 30% respectively. IgG antibody titers generally remained at a constant level for more than 50 days, whereas IgA and IgM antibody titers declined more rapidly to normal values within 30 to 50 days after onset of clinical symptoms. Detection ofCampylobacter jejuni specific IgA antibodies in a single serum sample provided the most useful assay for serological diagnosis ofCampylobacter jejuni enteritis. The presence ofCampylobacter jejuni specific IgM antibodies was the sole diagnostic criterion in three cases. Serological diagnosis ofCampylobacter jejuni enteritis should therefore include both IgA and IgM antibody determination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01962343
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    Paper (German National Licenses)
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