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  • 1
    ISSN: 1436-2813
    Keywords: Lipiodol Ultra-Fluid ; Doxorubicin ; Urografin ; selective cancer chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve-day-old VX2 carcinoma was inoculated in the hind leg of 24 rabbits and, after 12 days, Doxorubicin (Adriamycin) suspended in Lipiodol Ultra-Fluid (Lipiodol) was then given through the femoral artery. A selective deposit of the contrast material in the tumor for an extended time was evident on the x-rays and the antitumorous effect was remarkable. Lipiodolized antitumor agents warrant further investigation for possible clinical application.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1436-2813
    Keywords: nonresectable hepatic tumor ; vascular accessgraft ; intraarterial chemotherapy ; liver cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgery today 14 (1984), S. 432-433 
    ISSN: 1436-2813
    Keywords: Inokuchi liver clamp ; hepatic resection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We designed a new clamp (Inokuchi liver clamp), mainly used for partial or wedge resection of the liver. This clamp is gently curved and has 9 non-traumatic teeth with double step locking devices at the tips. This clamp proved to be most useful for limited hepatic resection, a common procedure for primary liver cancer associated with cirrhosis, however, it can also be used for major resections. From August 1981 to February 1984, this clamp was used by our surgical team in 45 resections of the liver for primary and secondary malignant tumors and benign hemangiomas.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-2813
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We designed a transparent box to reconstruct cross sectional computed tomography (CT) imagings of the liver into a three dimensional form. The objective was to clearly visualize the area of lesion and to facilitate clinical teaching. This box (31.5×22.0×18.5 cm) is made of acrylic board containing 16 demountable panels layered horizontally at 10-mm intervals. The transparency of the CT film is projected onto these panels at each height of the liver, and findings including location of the tumor, main vessels and adjacent organs are outlined with an erasable marker. After completion of each tracing, the panels are replaced in the box and the total layer forms a completed picture of the CT findings. Since 1981, we have used this tool to assess resectability and/or to select adequate procedures for treating 54 patients with liver tumor. The solid picture gives an definite location of the tumor and its extension. In the clinical work-up, indication for surgery and a procedure of choice can be discussed by the team, using this visual aid.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Surgery today 13 (1983), S. 32-36 
    ISSN: 1436-2813
    Keywords: small liver cancer ; early detection ; diagnostic sensitivity ; operative management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report eight cirrhotic patients with liver cancer of less than 2 cm in diameter, and who were successfully treated by surgery. The sensitivities of diagnostic procedures for small lesions showed that alpha-fetoprotein (AFP) was 75 per cent, radionuclide scanning 25 per cent, CT 33 per cent, ultrasonography 40 per cent and angiography 88 per cent. Serial measurement of AFP appears to be the most helpful for detection of hepatocellular carcinoma at the early stage, particularly in cirrhotic patients. Although hepatic imagings are of limited value for small hepatic tumors, those tools are often useful as a back-up for the routine tests but not for initial procedures. It should also be kept in mind that hepatic arteriography performed in the high risk group often leads to detection of small cancers. In cirrhotic patients with small hepatocellular carcinoma, surgical resection should be done, providing the clinical status and hepatocellular reserve are adequate.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le traitement du cancer du foie associé à des varices oesophagiennes fut pratiqué chez 8 cirrhotiques qui présentaient une hypertension portale. Chez 5 malades, admis pour le traitement chirurgical de varices oesophagiennes, un cancer limité du foie fut décelé au moment de l'exploration opératoire. Chez 3 malades le diagnostic d'hépatome avait été porté avant l'intervention. L'exérèse de la tumeur du foie suivie d'une anastomose porto-cave fut pratiquée avec succès chez 6 malades. Le traitement simultané des varices oesophagiennes et du cancer du foie est possible quand la tumeur hépatique est découverte à un stade précoce. Le procédé le plus fiable pour aboutir à un diagnostic exact est représenté par l'artériographie hépatique. Notre propre expérience nous incite donc à recommander l'étude artériographique chez les cirrhotiques, particulièrement quand on envisage de traiter chirurgicalement les varices oesophagiennes.
    Notes: Abstract Surgical treatment of liver cancer associated with esophageal varices was carried out in 8 cirrhotic patients with evidence of portal hypertension. In 5 patients admitted for elective surgery of esophageal varices, minute hepatomas were detected during the course of preoperative investigation. The remaining 3 patients were referred to our department when esophageal varices plus hepatoma had become evident. Extirpative treatment of the liver tumor followed by selective shunt operations were successfully carried out in 6 patients, and interrupted procedures were used in 2 patients. Treatment of both esophageal varices and liver cancer appears to be effective when the tumor in the liver is detected in an early stage. The most reliable diagnostic tool at the present time seems to be hepatic arteriography. Our experience strongly suggests that arteriographic studies should be seriously considered in cirrhotic patients, particularly when surgery for varices is being contemplated.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs ont étudié les suites opératoires de 50 malades qui avaient subi une résection hépatique en comparant les taux de rétention de l'indocyanine green (ICG) mesurés lors du 3ème jour post-opératoire par rapport à ceux appréciés immédiatement après l'opération. Ce rapport étant l'expression de l'index ICG du parenchyme restant. Le groupe A de 22 malades avec un index restant de moins de 1.0, (qui signifie le taux de rétention de ICG à 15 mm lors du 3ème jour post-opératoire) a montré une amélioration par comparaison aux faits qui ont succédé immédiatement à l'intervention. Un groupe B de 28 malades chez qui l'index au 3ème jour était supérieur à 1.0, indiquant par conséquent une élévation du taux de clarance de l'ICG après résection hépatique, a été individualisé. De sérieuses complications comprenant infection abdominale et hyperbilirubinémie se sont manifestées en post-opératoire respectivement chez 2 (9.1%) du groupe A et 16 (57.1%) du groupe B (p〈0.001). Un malade (4.5%) du groupe A décéda cependant que 9 malades (32.1%) du groupe B moururent pendant l'hospitalisation (p〈0.02). Il ne fut pas constaté de différence significative en ce qui concerne la fonction hépatique préopératoire et les paramètres cliniques. Ces observations suggèrent que l'amélioration du taux de la clairance de l'ICG au 3ème jour post-opératoire par comparaison au taux déterminé immédiatement après l'intervention permet de préjuger des suites post-opératoire après résection hépatique.
    Abstract: Resumen Hemos valorado la evolución postoperatoria de 50 pacientes sometidos a resección hepática, utilizando la relación entre las tasas de retención del verde de indocianina (VIC) medidas en el tercer día postoperatorio y los valores estimados inmediatamente después de la operación. Esta relación fue expresada en forma del indice VIC de remanente hepático. El grupo A incluyó 22 pacientes con un indice de menos de 1.0, lo cual significa que la tasa de retención VIC a los 15 minutos en el tercer día postoperatorio mostró mejoría en comparación con los hallazgos inmediatamente al término de la operación. En el grupo B hubo 28 pacientes cuyos indices en el tercer día postoperatorio fue superior a 1.0, lo cual indica exacerbación de la tasa de depuración de VIC después de la resección hepática. Se presentaron complicaciones postoperatorias graves, incluso sepsis intraabdominal e hiperbilirrubinemia en 2 (9.1%) en el grupo A y 16 (57.1%) en el grupo B (p〈0.001). Murió un paciente (4.5%) en el grupo A contra 9 pacientes (32.1%) que murieron en el grupo B en el curso de la hospitalización (p〈 0.02). No se observaron diferencias significativas en cuanto a las pruebas preoperatorias de función hepática o los parámetros clínicos. Estas observaciones sugieren que la mejoría en la tasa de depuración de VIC en el tercer día postoperatorio, comparada con aquella inmediatamente al término de la operación, es un paramétro de utilidad en la predicción del curso postoperatorio de pacientes hepatectomizados.
    Notes: Abstract We evaluated the postoperative course of 50 patients who underwent hepatic resection, using the ratio of indocyanine green (ICG) retention rates measured on the third postoperative day to values estimated immediately after the operation. This ratio was expressed as the remnant liver ICG index. Group A included 22 patients with a remnamt liver ICG index of less than 1.0, which meant that the ICG retention rate at 15 minutes on the third postoperative day showed improvement, compared to events immediately after the operation. In group B, there were 28 patients whose index on the third postoperative day was over 1.0, thereby indicating exacerbation of the ICG clearance rate after hepatic resection. Serious complications including intraabdominal sepsis and hyperbilirubinemia occurred postoperatively in 2 (9.1%) in group A and 16 (57.1%) in group B (p〈0.001). One patient (4.5%) in group A died, while 9 patients (32.1%) in group B died during hospitalization (p〈 0.02). There were no significant differences with regard to preoperative liver function and clinical parameters. These observations suggest that improvement in the ICG clearance rate on the third postoperative day, compared to that immediately after the operation, is useful to predict the postoperative course of hepatectomized patients.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1436-2813
    Keywords: computed tomography ; scintigraphy ; accessory spleen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Accessory spleens of 1.5 cm in size were preoperatively identified by the combined use of computerized tomography and splenic scintigraphy in two patients with hematologic diseases. After the accessory spleen had been removed from the first patient, who had persistent hereditary spherocytosis and had undergone a splenectomy 15 months before, a postoperative decrease in hyperbilirubinemia was noted. In the other patient who had idiopathic thrombocytopenic purpura, a successful accessory splenectomy was done at the same time as her splenectomy, and was followed by 6 months' complete remission. These events indicate that preoperative investigations using computerized tomography and scintigraphy are indispensable for ruling out an accessory spleen in those patients for whom splenectomy needs to be done in order to alleviate hematologic disorders.
    Type of Medium: Electronic Resource
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