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  • 1
    Electronic Resource
    Electronic Resource
    The acute renal haemodynamic and endocrine response to felodipine in normal man (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 581-585 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; calcium antagonists ; renal haemodynamics ; prostaglandins ; kallikrein ; PGF 1 α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Felodipine (0.075 mg/kg p.o.), a calcium antagonist, was given to 9 male volunteers, with and without indomethacin pretreatment. Diuresis and natriuresis occurred after felodipine without significant change in effective renal plasma flow or glomerular filtration rate. There was no significant change in urinary 6 keto PGF 1 α or urinary kallikrein excretion and indomethacin did not inhibit the natriuretic or diuretic response to felodipine. The felodipine induced diuresis and natriuresis appears most likely to be mediated by an action of the drug on renal tubules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542491
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  • 2
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    Moral and Conceptual Issues in Investment and Finance: An Overview (1988)
    Dordrecht : Periodicals Archive Online (PAO)
    Journal of Business Ethics. 7:1/2 (1988:Jan.) 3 
    Details
    ISSN: 0167-4544
    Topics: Philosophy , Economics
    Notes: MORAL AND CONCEPTUAL ISSUES IN INVESTMENT AND FINANCE
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:m089-1988-007-01-000002
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of Amiodarone and Desethylamiodarone on the Pharmacokinetics of Antipyrine in the Rat (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 251-254 
    Details
    ISSN: 1573-904X
    Keywords: amiodarone ; antipyrine ; desethylamiodarone ; drug metabolism ; drug interactions ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect of amiodarone on hepatic drug metabolism in vivo was examined in the rat using antipyrine as a model substrate. Pretreatment with oral amiodarone hydrochloride, 100 mg/kg/day, for 5 days resulted in a 19% reduction in antipyrine clearance and a 22% increase in half-life. The administration of single oral doses of amiodarone hydrochloride, 100 mg/kg, 1 or 5 hr prior to antipyrine administration had no significant effect on antipyrine pharmacokinetics. The administration of a single intravenous dose of amiodarone hydrochloride, 50 mg/kg, reduced antipyrine clearance by 32% and increased the half-life by 46%. The desethyl metabolite of amiodarone was also found to reduce antipyrine clearance (21%) after a single oral dose of 100 mg/kg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016468430618
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  • 4
    Electronic Resource
    Electronic Resource
    Dextromethorphan Pretreatment Induces Antipyrine Clearance in the Rat (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 437-439 
    Details
    ISSN: 1573-904X
    Keywords: antipyrine ; dextromethorphan ; drug metabolism ; enzyme induction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Numerous agents that undergo extensive first-pass metabolism have been shown to inhibit oxidative drug metabolism. To examine whether this effect is related to the chemical structure or pharmacokinetic characteristics of the inhibiting agent, we determined the effect of dextromethorphan (a compound which exhibits pharmacokinetic similarities to, but is chemically dissimilar from, previously studied agents) on the disposition of antipyrine. A single oral dose of dextromethorphan hydrobromide, 100 mg/kg, 1 hr prior to antipyrine administration had no significant effect on the pharmacokinetics of this model substrate. The administration of dextromethorphan at the same dose twice daily for 3 days and an additional dose 1 hr prior to antipyrine administration resulted in a 33% increase in the clearance of antipyrine. These data indicate that dextromethorphan is capable of inducing hepatic microsomal enzymes. Studies are needed to determine if this effect also occurs upon chronic administration in humans. These data suggest that the pharmacokinetic characteristic of extensive first-pass metabolism is not necessarily associated with inhibition of drug metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015940518439
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of the Immunomodulator Tilorone on the in Vivo Acetylation of Procainamide in the Rat (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 477-480 
    Details
    ISSN: 1573-904X
    Keywords: acetylation ; immunomodulators ; interferon inducers ; pharmacokinetics ; procainamide ; tilorone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Interferon and interferon inducers have been found to inhibit cytochrome P-450-dependent metabolism in animals and man. The effect of these agents on the acetylation of drugs has not been previously reported. Since these agents stimulate the reticuloendothelial system, together with the abundance of N-acetyltransferase in the reticuloendothelial system, it was hypothesized that these immunomodulators may affect drug acetylation. To test this hypothesis, the effect of tilorone (a synthetic interferon inducer) on the in vivo acetylation of procainamide was examined in the rat. Pretreatment with tilorone hydrochloride (50 mg/kg) 48 hr prior to the administration of procainamide hydrochloride (50 mg/kg) resulted in a 32% increase in the urinary recovery of N-acetylprocainamide and a 35% increase in the metabolic clearance of procainamide to N-acetylprocainamide. These data indicate that interferon inducers increase the N-acetylation of drugs in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015964306318
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  • 6
    Electronic Resource
    Electronic Resource
    Pacifism as a moral ideal (1988)
    Springer
    The journal of value inquiry 22 (1988), S. 267-277 
    Details
    ISSN: 1573-0492
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy
    Notes: Conclusion In conclusion I would like to forestall one potential misunderstanding. As I have described it the pacifist ideal may seem so difficult to attain that it may seem closed off from the aspirations of ordinary human beings; and there is no doubt that few people are likely to attain this ideal to any great degree. This accords with our intuition that “true,” by which I think we mean “paradigm” pacifists, are rare indeed. But ideals can be sought, as well as attained, to greater or lesser degrees. So there are many ordinary people who regard themselves as pacifists because they avoid violence more scrupulously than most. On my analysis their claim might well be true.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00136929
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  • 7
    Electronic Resource
    Electronic Resource
    Moral and conceptual issues in investment and finance: An overview (1988)
    Springer
    Journal of business ethics 7 (1988), S. 3-8 
    Details
    ISSN: 1573-0697
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381991
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Hydralazine on the Elimination of Antipyrine in the Rat (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 515-518 
    Details
    ISSN: 1573-904X
    Keywords: antipyrine ; drug metabolism ; hydralazine ; hypothermia ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The concomitant administration of hydralazine with metoprolol or propranolol substantially increases the oral bioavailability of these beta-blockers, presumably via reduction of the first-pass effect. It has been suggested that this effect may be secondary to a decrease in the intrinsic clearance of propranolol, possibly by inhibition of oxidative metabolism. To examine the possibility that hydralazine alters oxidative metabolism in vivo, the effect of hydralazine on the pharmacokinetics of antipyrine was examined in the rat. The oral administration of hydralazine hydrochloride, 7.5 mg/kg, 15 min prior to antipyrine administration reduced antipyrine clearance from 9.66 ± 1.18 to 8.19 ± 0.76 ml/min/kg (P 〈 0.05). Hydralazine was observed to cause substantial hypothermia. The study was repeated in temperature-regulated animals and no alteration in antipyrine clearance was found. Two doses of hydralazine in temperature-regulated rats also failed to alter antipyrine clearance. Thus, it appears that the effect of hydralazine on antipyrine clearance is secondary to the hypothermic effect of hydralazine and not due to a direct inhibition of cytochrome P-450-mediated enzyme activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016487824200
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  • 9
    Electronic Resource
    Electronic Resource
    Resonant AC-DC magnetic fields: Calculated response (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 9 (1988), S. 315-336 
    Details
    ISSN: 0197-8462
    Keywords: ELF ; cyclotron resonance ; model ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: An elementary model consisting of one charged particle in a viscous medium exposed to weak ac-dc low-frequency magnetic fields is analyzed to identify and explain the fundamental characteristics of the physical mechanisms that result in a resonance response, which is similar to the familiar cyclotron resonance. The model predicts both frequency and amplitude windows, which are explained in terms of synchronization of the particle with electric fields. Although extrapolation of model results to biological systems is limited by the elementary nature of the model, the model results indicate that observed resonant responses by others of biological systems to ac-dc magnetic fields are probably not due to resonant response of ions in solution, since the model predicts that no resonant response is possible unless the viscous damping is very low, many orders of magnitude lower than the viscous damping of ions in solution.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250090402
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