ISSN:
1432-1041
Keywords:
felodipine
;
calcium antagonists
;
renal haemodynamics
;
prostaglandins
;
kallikrein
;
PGF 1 α
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Felodipine (0.075 mg/kg p.o.), a calcium antagonist, was given to 9 male volunteers, with and without indomethacin pretreatment. Diuresis and natriuresis occurred after felodipine without significant change in effective renal plasma flow or glomerular filtration rate. There was no significant change in urinary 6 keto PGF 1 α or urinary kallikrein excretion and indomethacin did not inhibit the natriuretic or diuretic response to felodipine. The felodipine induced diuresis and natriuresis appears most likely to be mediated by an action of the drug on renal tubules.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542491
