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  • 1
    Electronic Resource
    Electronic Resource
    Antibody assay of rabbit sera for outer membrane vesicles ofHaemophilus influenzae by enzyme-linked immunosorbent assay (1985)
    Springer
    Medical microbiology and immunology 174 (1985), S. 197-203 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enzyme-linked immunosorbent assay (ELISA) was applied to the detection of IgG and IgM antibodies against outer membrane vesicles (OMV) antigen ofHaemophilus influenzae type b. In this ELISA system, IgG antibody titers were about 40 fold higher than those in indirect hemagglutination assay (IHA). The IgG antibody titers by this ELISA of rabbit sera obtained after immunization were comparable with those by radioimmunoassay (RIA) of the same sera. A significant correlation was established between these two assays (r=0.973,P〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123696
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of an intracellular calcium antagonist HA 1077 on delayed cerebral vasospasm in dogs (1988)
    Springer
    Acta neurochirurgica 90 (1988), S. 53-59 
    Details
    ISSN: 0942-0940
    Keywords: Calcium antagonist ; chronic cerebral vasospasm ; HA 1077 ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effectiveness of calcium antagonists on a chronic cerebral vasospasm after an SAH is still under debate. Calcium channel blockers such as nimodipine, nefedipine etc. can dilate spastic arteries by intrathecal administration, but not by systemic (iv or po) use. HA 1077 is a novel and potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits 1. calcium ionophore A 23187 induced contraction in arterial strips and 2. phenylephrine induced contraction in calcium free media, suggesting that its site of action is in the intracellular space. HA 1077 is water soluble and relatively stable in light. In the present study, the efficacy of HA 1077 was evaluated on dogs by using the spiral arterial strips in vitro and by angiography in vivo. In the arterial strips from the control dogs, a 50% relaxation of KCl (15 mM) induced contraction was obtained by a 10−6 M HA 1077 for the “intracranial” basilar and middle cerebral arteries, while a 10−5 M was needed to obtain the same effect for the “extracranial” common carotid and vertebral arteries, indicating that HA 1077 is more effective for the intracranial arteries. A vasospasm was produced by the “two haemorrhage” model of Varsoset al. The average angiographic diameter of the basilar artery was reduced to 60% of the control on SAH day 7. Intravenous infusion of HA 1077 (0.5–3 mg/kg/30 min) significantly dilated the spastic basilar artery (up to 20–30%), for over 2 hours. A fall in the systemic BP remained less than 20% during this time. Such spasmolytic effects by intravenous administration could not have been obtained with the usual calcium channel blockers. HA 1077 may be suitable for the treatment of a vasospasm in humans as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541267
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of Temperature and Time on Cooking Kinetics of Potatoes (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 50 (1985), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: To study cooking kinetics, slices (6 mm thick, 30 mm diameter) of 3 potato varieties were treated in water at 90°, 100° and 110°C for varying times. Sensory, chemical and physical properties were investigated. Changes during cooking at constant temperature were mathematically described by a 0 order (texture, taste) and a 1st order (shear force, dry matter, pectin, soluble amylose, cell size) equation. The starch content remained constant. Temperature dependence of the rate constant could always be described by a first order equation. The z-values, which are necessary to calculate Cvalue for practical heat treatments, could be determined. Correlations established between kinetics of different properties showed that behavior of certain potato properties may be predicted by shear-force measurement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1985.tb13427.x
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of the Composition of Potatoes on Their Cooking Kinetics (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 50 (1985), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A previous study of three potato varieties indicated that shear force measurement may be used to predict the behavior of certain potato properties during cooking. To verify this hypothesis and to confirm other previous findings, slices (6 mm thick, 30 mm in diameter) of 21 potato varieties were thermally treated in water at 100°C. Mathematical expressions were assessed, and coefficients were determined to describe the kinetic behavior of the varieties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1985.tb13428.x
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  • 5
    Electronic Resource
    Electronic Resource
    Novel method to fabricate corrugation for a λ/4-shifted distributed feedback laser using a grating photomask (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 415-417 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A novel method was developed to fabricate corrugation for a λ/4-shifted distributed feedback (DFB) laser. Mechanically ruled grating patterns were transferred photolithographically to the surface of an InP substrate. The resultant λ/4-shifted DFB laser operated in a single longitudinal mode at the Bragg wavelength.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.101882
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  • 6
    Electronic Resource
    Electronic Resource
    CHOLINERGIC NEUROMODULATION BY ATP, ADENOSINE AND ITS N6-SUBSTITUTED ANALOGUES IN GUINEA-PIG ILEUM (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of ATP, adenosine and N6-substituted adenosines, adenosine receptor agonists, on the twitch contraction of guinea-pig ileum evoked by transmural stimulation were evaluated.2. Adenosine and ATP produced an immediate and concentration dependent inhibition of the twitch, IC50 being 1.1 × 10−5 mol/l and 1.2 × 10−5 mol/l, respectively.3. N6-l-phenylisopropyl adenosine (L-PIA), N6-cyclohexyl adenosine (CHA) and N6-allyl adenosine also induced inhibitions which were gradual and persistent, IC50 being 2.6 × 10−8, 2.7 × 10−8 and 5.4 × 10−7 mol/l, respectively.4. Dipyridamole (10−7 mol/l), an adenosine uptake inhibitor, markedly augmented the inhibition evoked by adenosine and ATP, but not that by three N6-substituted adenosines, while theophylline (10−4mol/l) almost completely antagonized the inhibitory effects of all purine compounds. IC50 value of adenosine in the presence of dipyridamole (5 × 10−7 mol/l) was shifted to the left about 50 times from the control, whereas that of L-PIA was virtually unchanged.5. Tissue-medium ratios indicating uptake of [H]adenosine, [3H]ATP and [3H]CHA into the segment were 3.23 (s.e.m. =0.59), 3.59 (s.e.m. =0.78) and 0.41 (s.e.m. =0.04), respectively.6. These results suggest that not only adenosine and ATP but also these N6-substituted adenosines are potent agonists for the PI receptor, implying a similarity between PI and A, receptor in a functional role and these purine compounds may thereby modulate cholinergic neurotransmission by altering adenylate cyclase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb00305.x
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  • 7
    Electronic Resource
    Electronic Resource
    Angiosarcoma with dermal melanocytosis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 16 (1989), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a case of angiosarcoma and dermal melanocytosis occurring simultaneously in the same lesion. We examined the primary and 2 metastatic lesions. Histopathologically, the anaplastic angiosarcoma cells had a tendency to form irregularly shaped small cavities. Immunohistochemically, they were strongly reactive with Ulex europaeus agglutinin (UEAI) stain. The mid and deep dermis of the same lesion had spindle or elongated slender melanocytes containing melanin granules. The melanocytes were positive with S-100 protein stain. Ultrastructurally, pinocytotic vesicles, fine filaments, and Weibel-Palade body-like dense granules were observed in the cytoplasm of angiosarcoma cells. Dermal melanocytes had external lamina and melanosomes in various stages. The melanocytes showed no similarity to the neoplastic tumor cells and there was no apparent intermediate form between the 2 kinds of cells. The etiological implications of dermal melanocytosis with a tumor of vascular origin are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1989.tb00030.x
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  • 8
    Electronic Resource
    Electronic Resource
    Hemophilus influenzae adherence to and absorption from the nasal mucosa of guinea pigs (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 218-221 
    Details
    ISSN: 1434-4726
    Keywords: Mucosal absorption ; Bacterial adherence ; Hemophilus influenzae ; Outer membrane vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The adherence to and the absorption from nasal mucosal epithelium of type b and non-typeable strains of Hemophilus influenzae were studied in guinea pigs. H. influenzae bacteria were administered to the nose as 4×107 organisms in 1.0 ml saline. The outer membrane vesicles (OMV) of H. influenzae were used in the absorption study. Scanning electron microscopic studies showed that H. influenzae cells attached to both ciliated and non-ciliated cells of the nasal mucosa. Histological studies showed that OMV were absorbed through the nasal mucosa, mainly from ciliated cells. Further, penetration of OMV through the nasal mucosa of immunized animals was reduced when compared with that of non-immunized ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453666
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  • 9
    Electronic Resource
    Electronic Resource
    Osteopathia striata with cranial sclerosis affecting three family members (1985)
    Springer
    Skeletal radiology 14 (1985), S. 267-269 
    Details
    ISSN: 1432-2161
    Keywords: Osteopathia striata ; Cranial sclerosis ; Mandible ; Osteopoikilosis ; Osteosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Skeletal surveys were performed on a 38-year-old Japanese mother, her son and daughter. The radiographs of both children showed characteristic features of osteopathia striata. However, in the mother, the skull, mandible, and lower extremities were homogeneously sclerotic with no evidence of a striated pattern of sclerosis in her skeleton. Additional features of striated sclerosis of the mandible in patients with osteopathia striata are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352617
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  • 10
    Electronic Resource
    Electronic Resource
    Six cases of central serous choroidopathy induced by systemic corticosteroid therapy (1985)
    Springer
    Documenta ophthalmologica 60 (1985), S. 37-44 
    Details
    ISSN: 1573-2622
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report 6 cases of central serous choroidopathy (including pigment epithelial detachment in one case) which appeared in the course of systemic corticosteroid administration conducted to cure concurrent general diseases, and in one patient with a steroidreleasing pituitary adenoma. The majority of cases arose within about one month following the administration of more than 200 mg of prednisolon. It is postulated that corticosteroids operate as a kind of stress intervening in the hypophysis-adrenal system, leading eventually to the development of central serous choroidopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164568
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