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  • 1
    Electronic Resource
    Electronic Resource
    Administration of recombinant IL-2 augments the level of serum IgM in an IL-2 deficient patient (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 630-633 
    Details
    ISSN: 1432-1076
    Keywords: IL-2 deficiency ; IL-2 therapy ; IgM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with ataxia telangiectasia was treated with recombinant interleukin-2 (rIL-2) and the resulting immunological effects evaluated. The patient lacked IL-2 production, and immunoglobulin synthesis was also impaired. Treatment with IL-2 selectively increased serum IgM without any significant side effects. Therapy also restored B-cell function in vitro, IgM production as well as the proliferative response to Staphylococcus aureus strain Cowan I. These results suggest that IL-2 treatment may correct both T-cell and B-cell defects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441517
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of substance P-containing nerve fibres in glomus tumours (1985)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 113 (1985), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Substance P (SP), S-100 protein, methionine-enkephalin, serotonin and myelin basic protein were studied in two solitary glomus tumours of the skin by peroxidase-antiperoxidase immunohistochemistry. Multiple SP-containing nerve fibres were distributed in the parenchyma of the tumour among proliferating glomus cells, and in the oedematous stroma of the tumour. Positive staining for myelin basic protein was detected in nerve fascicles in the capsule of the tumour, but not within the glomus tumour. S-100 protein immunoreactivity was found in nerve fascicles in the capsule of the tumour, and in addition, a few cells positive for S-100 protein were scattered throughout the stroma of the tumour. No positive staining for methionine-enkephalin and serotonin was found. The present finding may explain the clinical experience that the tumour is tender and can cause severe paroxysmal pain, because SP is known to be a primary sensory afferent neurotransmitter for mediating nociception. A possible role of SP for vasodilation in the glomus tumour is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1985.tb02067.x
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  • 3
    Electronic Resource
    Electronic Resource
    Multipurpose four-circle diffractometer with a crystal analyzer for use with synchrotron radiation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 2406-2409 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper describes the performance of a four-circle diffractometer installed at the Photon Factory for extensive use with synchrotron radiation for various investigations in the field of solid state physics. Its main part is based on a Huber 5020.4 type diffractometer with a crystal analyzer designed for vertical diffraction plane attitude. The diffractometer is mounted on a carriage table, which can precisely adjust the position of the diffractometer with respect to the incident beam monochromatized by successive reflection from a pair of Si(111) crystals. With a perfect crystal used as the analyzer the large size of the ω and 2θ circles enables us to make high resolution (ΔQ/Q∼10−4) measurements of x-ray scattering intensity distribution from a single crystal. The large space in the center of the diffractometer permits us to put a pressurizing cell or a cryostat on the φ table for scattering measurements at controlled pressures and temperatures. Selected examples of the application are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140731
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  • 4
    Electronic Resource
    Electronic Resource
    Reduction processes of amorphous GeO2 by hydrogen (1987)
    Springer
    Journal of materials science 6 (1987), S. 149-150 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728967
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical application of chitin non-woven fabric as wound dressing (1987)
    Springer
    European journal of plastic surgery 10 (1987), S. 66-69 
    Details
    ISSN: 1435-0130
    Keywords: Chitin ; Wound dressing ; Donor site ; Local therapy of burn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new wound dressing, chitin non-woven fabric was applied in 91 patients for dressing of donor sites, skin graft areas, raw areas under pedicle flaps and those associated with skin abrasion, as well as burns and skin ulcers. Chitin dressing showed excellent results with regard to satisfactory pain relief, adherence to the wound and drying without dissolution or other adverse effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578375
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  • 6
    Electronic Resource
    Electronic Resource
    Disturbed function of the pineal gland in familial amyloid polyneuropathy (1987)
    Springer
    Journal of neural transmission 69 (1987), S. 97-103 
    Details
    ISSN: 1435-1463
    Keywords: Pineal gland ; familial amyloid polyneuropathy ; 6-hydroxymelatonin ; metanephrine ; normetanephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to estimate the function of the pineal gland, the sympathetic nervous system and the adrenal medulla in patients with familial amyloid polyneuropathy relative to healthy subjects, we have quantified urinary 6-hydroxymelatonin, normetanephrine and metanephrine. Urinary 6-hydroxymelatonin level correlated with neither of two O-methylated catecholamine levels in healthy subjects. The excretion of both 6-hydroxymelatonin and metanephrine were reduced in the patient group as compared with the control group, and the normal daily rhythm of 6-hydroxymelatonin was undetectable in the most of the patients. This finding indicates that the function of the pineal gland is disturbed in familial amyloid polyneuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244100
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  • 7
    Electronic Resource
    Electronic Resource
    The aortic alpha1-adrenergic receptor in familial amyloidotic polyneuropathy (1988)
    Springer
    Journal of neural transmission 73 (1988), S. 23-30 
    Details
    ISSN: 1435-1463
    Keywords: Familial amyloidotic polyneuropathy ; aorta ; alpha1-adrenergic receptor ; 3H-bunazosin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the pathophysiology of the sympathetic nervous system in familial amyloidotic polyneuropathy (FAP), we used3H-bunazosin to identify and characterize the alpha1-adrenergic receptor in human aortic membranes. The binding of3H-bunazosin was rapid, readily reversible, stereospecific, and saturable. The Scatchard analysis described a single class of binding sites with a dissociation constant (KD) of 0.370±0.035nM and a maximal binding capacity (Bmax) of 11.8±1.30 fmol/mg protein in control patients. Competition analysis demonstrated the alpha1-adrenergic specificity of the3H-bunazosin binding sites in human aortic membranes. The KD and Bmax of3H-bunazosin binding in four FAP patients was 0.274±0.052 nM and 7.79±0.15 fmol/mg protein, respectively; these values did not differ significantly from those in 14 control patients. An increase in Bmax or affinity of alpha1-adrenergic receptors may not be the cause for denervation supersensitivity in FAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244619
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  • 8
    Electronic Resource
    Electronic Resource
    Beneficial effect of coenzyme Q on myocardial slow action potentials in hearts subjected to decreased perfusion pressure—hypoxia—substrate-free perfusion (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 147-155 
    Details
    ISSN: 1435-1803
    Keywords: coenzyme Q ; ischemia ; slow action potential ; cardiac contraction ; adenine nucleotides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Coenzyme Q, an important component of the electron transfer system in mitochondria, plays a central role in energy production aerobically. The effect of pretreatment with coenzyme Q10 (Co Q) on myocardial slow action potentials (APs) and accompanying contractions and on myocardial high energy phosphate content was studied in perfused hearts subjected to decreased perfusion pressure—hypoxia—substrate-free. Post-hatched chicks were treated i.p. with 10 mg/kg of Co Q daily for 5 days. To study the slow APs exclusively, the fast Na+ channels were voltage-inactivated by elevated K+ (25 mM) Tyrode solution. The Ca++-dependent slow APs were induced by elevating [Ca]0 to 5.4 mM; hearts were paced at a rate of 40 per min. Hearts which had been pretreated with Co Q were protected against the deleterious effect of decreased perfusion pressure—hypoxia—substrate-free perfusion on mechanical performance accompanying the slow Ca++−Na+ APs. The slow APs in hearts pretreated with Co Q were also less affected than were non-treated hearts. However, the myocardial ATP and total adenine nucleotides were not affected by exogenous Co Q. It was suggested that exogenous Co Q could protect against the decline of cardiac contractions via improved availability of slow APs during decreased perfusion pressure—hypoxia—substrate-free, independently of the cellular high energy phosphate level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910462
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  • 9
    Electronic Resource
    Electronic Resource
    Protective effect of taurine against isoprenaline-induced myocardial damage (1986)
    Springer
    Basic research in cardiology 81 (1986), S. 473-481 
    Details
    ISSN: 1435-1803
    Keywords: isoprenaline ; cardiotoxicity ; calcium-overload ; taurine ; chick
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the sulfur amino acid, taurine, was examined on histological and biochemical changes induced by a toxic dose of isoprenaline in chick hearts. Isoprenaline treatment (80 or 240 mg/kg id twice daily for 4 days) caused a dose-dependent increase in heart weight and decrease in myocardial ATP. Isoprenaline administration (240 mg/kg id twice daily) produced necrotic changes in hearts, such as eosinophilic degeneration, myolysis, interstitial oedema, fibrosis, and inflammatory cell infiltration. Substantial accumulation of calcium was also observed. Taurine content of the heart was not significantly decreased. Parenteral administration of taurine (200 mg/day for 7 days) partially protected against these necrotic changes induced by isoprenaline. It is suggested that the protective effect of taurine against isoprenaline-induced myocardial injury might be due in part to the prevention of the massive overloading with calcium which is thought to cause myocardial cell necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907753
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