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Prolonged anaesthesia with isoflurane and halothane (1988)

JANTZEN, J.-P. A. H. ; KLEEMANN, P. P. ; WITTON, P. K. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Anaesthesia 43 (1988), S. 0

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ISSN: 1365-2044

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Hepatic function was assessed pre-operatively and on the first and sixth postoperative days in 40 healthy patients who underwent prolonged maxillofacial surgery with isoflurane or halothane anaesthesia. No major changes were observed in hepatic enzymes or bilirubin. One-stage prothrombin time and Factor VII concentrations decreased on the first postoperative day and this change-was more pronounced in the halothane group. The results support the use of isoflurane rather than halothane for prolonged anaesthesia in respect of the synthesising function of the liver.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb05536.x

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Failure of opioids to affect excitation and contraction in isolated ventricular heart muscle (1989)

Nawrath, H. ; Rupp, J. ; Jakob, H. ; [et al.]

Springer

Cellular and molecular life sciences 45 (1989), S. 337-339

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ISSN: 1420-9071

Keywords: Heart muscle ; opioids ; morphine ; ethylketocyclazocine ; cardiac function ; presynaptic modification

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The opioid agonists morphine (selective for μ-receptors) and ethylketocyclazocine (selective for kappa-receptors), at concentrations evoking strong effects in neuronal structures, did not significantly affect the configuration of the intracellularly recorded action potential and the force of contraction in ventricular heart muscle isolated from guinea pigs, rabbits and man. These results suggest that any changes of heart functions in vivo in response to opioid-like drugs are probably not mediated postsynaptically at the myocardial cell membrane but rather presynaptically, influencing the release of noradrenaline and/or acetylcholine from the nerve terminals.