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  • 1
    Electronic Resource
    Electronic Resource
    THE OUTPUT EFFECTS OF SPATIAL PRICE DISCRIMINATION REVISITED (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of regional science 28 (1988), S. 0 
    Details
    ISSN: 1467-9787
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Notes: Some prior findings on spatial price discrimination are extended. Under certain spatially defined market conditions, discriminatory pricing is known to yield greater output than does nondiscriminatory f.o.b. mill pricing. However, this seemingly surprising result is based on the form of the basic demand function which is relatively less convex than a certain standard curve. The present paper makes this prior result more general by permitting the assumed basic demand to be relatively more convex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9787.1988.tb01197.x
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of 2-(p-bromophenoxy)-N-ethyl-2-phenyl-N-(p-tolyl)ethanesulfonamide, C23H24BrNO3S (1985)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 41 (1985), S. 461-463 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270185004279
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  • 3
    Electronic Resource
    Electronic Resource
    Structure of a cyclopropyldiaminosulfonium salt (1989)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 45 (1989), S. 915-917 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270188014611
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  • 4
    Electronic Resource
    Electronic Resource
    Absence of tumor necrosis factor-α in suction blister fluids and stratum corneum from patients with psoriasis (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 398-400 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; Bioassay ; ELISA ; Tumor necrosis factor (TNF)-α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumor necrosis factor (TNF)-α is a cytokine with multiple biological properties, particularly proinflammatory, apart from the induction of tumor necrosis. In order to elucidate the role of TNF-α in the pathogenesis of psoriasis, we have carried out bioassay and enzyme-linked immunosorbent assay for TNF-α in suction blister fluids and horny tissue extracts from psoriatic skin. Although bioassay showed some activities in the suction blister fluids and horny tissue extracts, there were no significant differences between the levels of activities from normal and psoriatic skin. They were at the background level and pretreatment of the samples with anti-TNF-α antiserum failed to abrogate the activities. ELISA confirmed the absence of TNF-α. Therefore, the present study could not verify that TNF-α plays a major role in the pathogenesis of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455324
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 215-219 
    Details
    ISSN: 1432-1041
    Keywords: nilvadipine ; calcium antagonist ; essential hypertension ; antihypertensive drug ; stress ; cold pressor test ; haemodynamics ; plasma renin ; plasma noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immediate haemodynamic effects of the calcium antagonist nilvadipine have been studied in ten patients with established mild essential hypertension. Nilvadipine 4 mg p.o. reduced both the systolic and diastolic blood pressures within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate and cardiac index. The peak of blood pressure and total peripheral resistance reached during a cold pressor test were reduced by nilvadipine, but it did not affect the haemodynamic responsiveness to cold stimulation. Plasma renin activity was unaltered and the plasma noradrenaline concentration was increased only slightly. Thus, nilvadipine lowered blood pressure at rest and during cold stimulation as a result of arteriolar dilatation. The hypotensive effect at rest was associated with a reflex increase in heart rate and cardiac index.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637551
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of famotidine, a new H2-receptor antagonist, in relation to renal function (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 327-331 
    Details
    ISSN: 1432-1041
    Keywords: famotidine ; renal failure ; H2-receptor antagonist ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a new, potent H2-receptor antagonist, famotidine, 20 mg i.v. was studied in 7 subjects with normal renal function and in 24 patients with varying degrees of renal impairment. The volume of distribution at steady state was 1.14 l/kg in normal subjects and was not altered in renal failure. The half-life of elimination was 2.59 h in normal subjects and was unchanged in mild renal failure (creatinine clearance, CLCR 90–60 ml/min/1.48 m2) but was increased to 4.72 h in moderate renal failure (CLCR 60–30 ml/min/1.48 m2), and to 12.07 h in severe renal failure (CLCR below 30 ml/min/1.48 m2). The cumulative urinary excretion and renal clearance of famotidine were correspondingly reduced in patients with impaired kidney function. In normal subjects and in patients with mild to moderate renal failure, about 70% of famotidine was excreted through the kidney, mainly by tubular secretion. In patients with a CLCR above 60 ml/min/1.48 m2 the normal daily dose of famotidine can be employed, but in those with a CLCR between 60 and 30 ml/min/1.48 m2 the dose should be reduced by half, and in patients with a CLCR below 30 ml/min/1.48 m2 a reduction by three quarters of the normal dose is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543332
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of TZU-0460, a new H2-receptor antagonist, in patients with impaired renal function (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 709-712 
    Details
    ISSN: 1432-1041
    Keywords: TZU-0460 ; renal failure ; H2-receptor antagonist ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjects. These variables were not altered with renal impairment. Sixty percent of TZU-0460 given orally was excreted via the kidney, mainly by tubular secretion. The half-time of elimination was 3.94 h in normal subjects, and was prolonged to 12.13 h in severe renal failure (creatinine clearance below 30 ml/min/1.48 m2). Dosage adjustment of TZU-0460 is necessary in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608220
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  • 8
    Electronic Resource
    Electronic Resource
    Arthroscopic versus open synovectomy in the rheumatoid knee (1989)
    Springer
    International orthopaedics 13 (1989), S. 17-20 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons examiné et comparé les résultats cliniques et les observations radiologiques chez des patients présentant une arthrite rhumatoïde du genou, traites soit par synovectomie arthroscopique soit par capsulo-synovectomie chirurgicale, suivis pendant plus de dix ans en moyenne. Aucune différence significative n'a été constatée entre les deux groupes, les résultats cliniques globaux se dégradant d'une année à l'autre, dans les deux groupes, et ceci plus particulièrement, après la huitième année. Par contre, les changements ostéoarthritiques radiologiques ont été très sensibles dans le groupe capsulo-synovectomie, et il a été constaté également une différence significative entre la synovectomie arthroscopique et la capsulo-synovectomie au point de vue de la progression du »Larsen grade«. Nous en concluons que la synovectomie arthroscopique présente beaucoup d'avantages, et constitue une méthode de choix dans le traitement chirurgical d'une arthrite rhumatoïde du genou.
    Notes: Summary We report the clinical and radiological results after arthroscopic synovectomy (41 knees) and open capsulosynovectomy (26 knees) in patients with rheumatoid arthritis, with an average follow-up of more than ten years. The clinical outcome was much the same in both groups, but there was gradual deterioration, especially after eight years. Radiological changes of osteoarthritis were worse in the knees treated by open capsulosynovectomy compared with the arthroscopic group. Arthroscopic synovectomy has many advantages and we believe that it is better than open capsulosynovectomy for patients with rheumatoid arthritis of the knee.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266717
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  • 9
    Electronic Resource
    Electronic Resource
    Beneficial effect of coenzyme Q on myocardial slow action potentials in hearts subjected to decreased perfusion pressure—hypoxia—substrate-free perfusion (1985)
    Springer
    Basic research in cardiology 80 (1985), S. 147-155 
    Details
    ISSN: 1435-1803
    Keywords: coenzyme Q ; ischemia ; slow action potential ; cardiac contraction ; adenine nucleotides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Coenzyme Q, an important component of the electron transfer system in mitochondria, plays a central role in energy production aerobically. The effect of pretreatment with coenzyme Q10 (Co Q) on myocardial slow action potentials (APs) and accompanying contractions and on myocardial high energy phosphate content was studied in perfused hearts subjected to decreased perfusion pressure—hypoxia—substrate-free. Post-hatched chicks were treated i.p. with 10 mg/kg of Co Q daily for 5 days. To study the slow APs exclusively, the fast Na+ channels were voltage-inactivated by elevated K+ (25 mM) Tyrode solution. The Ca++-dependent slow APs were induced by elevating [Ca]0 to 5.4 mM; hearts were paced at a rate of 40 per min. Hearts which had been pretreated with Co Q were protected against the deleterious effect of decreased perfusion pressure—hypoxia—substrate-free perfusion on mechanical performance accompanying the slow Ca++−Na+ APs. The slow APs in hearts pretreated with Co Q were also less affected than were non-treated hearts. However, the myocardial ATP and total adenine nucleotides were not affected by exogenous Co Q. It was suggested that exogenous Co Q could protect against the decline of cardiac contractions via improved availability of slow APs during decreased perfusion pressure—hypoxia—substrate-free, independently of the cellular high energy phosphate level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910462
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  • 10
    Electronic Resource
    Electronic Resource
    Protective effect of taurine against isoprenaline-induced myocardial damage (1986)
    Springer
    Basic research in cardiology 81 (1986), S. 473-481 
    Details
    ISSN: 1435-1803
    Keywords: isoprenaline ; cardiotoxicity ; calcium-overload ; taurine ; chick
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the sulfur amino acid, taurine, was examined on histological and biochemical changes induced by a toxic dose of isoprenaline in chick hearts. Isoprenaline treatment (80 or 240 mg/kg id twice daily for 4 days) caused a dose-dependent increase in heart weight and decrease in myocardial ATP. Isoprenaline administration (240 mg/kg id twice daily) produced necrotic changes in hearts, such as eosinophilic degeneration, myolysis, interstitial oedema, fibrosis, and inflammatory cell infiltration. Substantial accumulation of calcium was also observed. Taurine content of the heart was not significantly decreased. Parenteral administration of taurine (200 mg/day for 7 days) partially protected against these necrotic changes induced by isoprenaline. It is suggested that the protective effect of taurine against isoprenaline-induced myocardial injury might be due in part to the prevention of the massive overloading with calcium which is thought to cause myocardial cell necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907753
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