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  • 1
    Electronic Resource
    Electronic Resource
    Lectin histochemistry of canine polyglucosan bodies (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 177-180 
    Details
    ISSN: 1432-0533
    Keywords: Lectins ; Polyglucosan bodies ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lectin histochemistry was investigated to identify sugar residues of the polyglucosan bodies of canine brain, spinal cord and caecum. The polyglucosan bodies in the brain and spinal cord stained with concanavalin A (ConA) but not with soybean agglutinin, wheat germ agglutinin, peanut agglutinin,Dolichos biflorus agglutinin,Ricinus communis agglutinin andUlex europaeus agglutinin. Caecum, polyglucosan bodies, however, did not stain with any of the seven lectins employed. After periodate oxidation, paradoxical ConA staining was observed in the polyglucosan bodies of the brain, spinal cord and caecum. These results indicate that polyglucosan bodies contain mannose and glucose residues and suggest that the component of polyglucosan bodies is partially derived from rough endoplasmic reticulum, the Golgi apparatus and hypolemmal cisternae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693785
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  • 2
    Electronic Resource
    Electronic Resource
    Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 283-286 
    Details
    ISSN: 1432-1076
    Keywords: Nephrotic syndrome ; Chlorambucil ; Central nervous toxicity ; Diffuse spike and wave complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chlorambucil (CHL) was used in combination with prednisolone in the treatment of nine children with frequently relapsing nephrotic syndrome. Serial electroencephalograms were obtained to evaluated CHL central nervous toxicity, before, during and after treatment with this agent. EEG abnormalities were observed in two of the nine children during chlorambucil therapy. EEG changes were diffuse spike and wave complexes and disappeared after discontinuation of therapy. There were no other neurological abnormalities and more particularly, no seizures or myocloni were observed. According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome. Strict neurological supervision of patients treated with chlorambucil is recomended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451963
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  • 3
    Electronic Resource
    Electronic Resource
    Carbamyl phosphate synthetase I deficiency with no detectable mRNA activity (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 406-408 
    Details
    ISSN: 1432-1076
    Keywords: Carbamyl phosphate synthetase-I ; Immunoblotting ; Cell-free protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the autopsied liver of a neonate with carbamyl phosphate synthetase (CPS)-I deficiency, the activity of CPS-I was about 9% of the normal neonatal control. The enzyme protein of CPS-I was hardly detectable by sodium dodecyl sulphate/polyacrylamide gel electrophoresis (SDS/PAGE) and an immunoblotting method using anti-rat liver CPS-I. The level of translatable mRNA for CPS-I was markedly decreased in a cell-free protein synthesis system consisting of rabbit reticulocyte lysate and total RNA extracted from the autopsied liver of the patient. These observations indicate that the enzyme deficiency in this case is probably mainly due to a diminished level of translatable mRNA, which would lead to a decrease in the synthesis of the CPS-I precursor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439249
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  • 4
    Electronic Resource
    Electronic Resource
    A case of hepatitis associated with carbamazepine therapy (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 666-666 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442493
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  • 5
    Electronic Resource
    Electronic Resource
    Prolonged ventilation of the premature newborn rabbit after treatment with natural or apoprotein-based artificial surfactant (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 168-173 
    Details
    ISSN: 1432-1076
    Keywords: Surfactant ; Hydrophobic apoproteins ; Premature newborn rabbits ; Lung compliance ; Image analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Premature rabbit neonates (gestational age 27 days) were treated at birth with natural surfactant purified from chloroform extracts of porcine lung lipids either by acetone precipitation (Surfactant CK, n=10) or liquid gel chromatography (Curosurf, n=22). Another group of animals received artificial surfactant “reconstituted” from isolated low molecular weight (≤15 K) apoproteins and synthetic dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG) (Aposurf, n=10). The phospholipid concentrations of the preparations were adjusted to provide the same individual dose of DPPC for each group of treated animals (3 or 4 mg). In comparison with untreated controls from the same litters, there was a 4–7-fold enhancement of lungthorax compliance in all groups of surfactant-treated animals during a 3-h period of artificial ventilation. The average initial (20 min) compliance value was lower in the Aposurf-treated group than in animals receiving natural surfactant preparations, but the difference between the groups gradually diminished and was no longer statistically significant during the 2nd and 3rd h of artificial ventilation. Judged from the fall in tidal volume during ventilation with a short expiration phase (0.17 instead of 0.75s), the apoprotein-based artificial surfactant was also less effective in stabilizing the lungs. A similar conclusion could be drawn from data on alveolar expansion in histological sections, evaluated by automated image analysis. Alveolar volume density was improved only moderately in the Aposurf-treated group (0.24 vs. 0.14; P=0.05), whereas the expected, prominent increase in this parameter was observed in both groups of natural surfactant-treated animals (0.48–0.62 vs. 0.14; P〈0.001). We conclude that a physiologically active artificial surfactant can be prepared from the smaller (≤15 K) apoproteins, DPPC and DPPG; the in vivo effects of this preparation were clearly beneficial, yet inferior to those obtained with the same dose of natural surfactant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442216
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  • 6
    Electronic Resource
    Electronic Resource
    Endocardial fibroelastosis in two siblings with the infantile type and the childhood type (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 583-584 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429081
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of an intracellular calcium antagonist HA 1077 on delayed cerebral vasospasm in dogs (1988)
    Springer
    Acta neurochirurgica 90 (1988), S. 53-59 
    Details
    ISSN: 0942-0940
    Keywords: Calcium antagonist ; chronic cerebral vasospasm ; HA 1077 ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effectiveness of calcium antagonists on a chronic cerebral vasospasm after an SAH is still under debate. Calcium channel blockers such as nimodipine, nefedipine etc. can dilate spastic arteries by intrathecal administration, but not by systemic (iv or po) use. HA 1077 is a novel and potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits 1. calcium ionophore A 23187 induced contraction in arterial strips and 2. phenylephrine induced contraction in calcium free media, suggesting that its site of action is in the intracellular space. HA 1077 is water soluble and relatively stable in light. In the present study, the efficacy of HA 1077 was evaluated on dogs by using the spiral arterial strips in vitro and by angiography in vivo. In the arterial strips from the control dogs, a 50% relaxation of KCl (15 mM) induced contraction was obtained by a 10−6 M HA 1077 for the “intracranial” basilar and middle cerebral arteries, while a 10−5 M was needed to obtain the same effect for the “extracranial” common carotid and vertebral arteries, indicating that HA 1077 is more effective for the intracranial arteries. A vasospasm was produced by the “two haemorrhage” model of Varsoset al. The average angiographic diameter of the basilar artery was reduced to 60% of the control on SAH day 7. Intravenous infusion of HA 1077 (0.5–3 mg/kg/30 min) significantly dilated the spastic basilar artery (up to 20–30%), for over 2 hours. A fall in the systemic BP remained less than 20% during this time. Such spasmolytic effects by intravenous administration could not have been obtained with the usual calcium channel blockers. HA 1077 may be suitable for the treatment of a vasospasm in humans as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541267
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  • 8
    Electronic Resource
    Electronic Resource
    Alterations of monoamine metabolites and of tryptophan in the basal cisternal CSF of patients after subarachnoid haemorrhage (1987)
    Springer
    Acta neurochirurgica 87 (1987), S. 58-62 
    Details
    ISSN: 0942-0940
    Keywords: Homovanillic acid (HVA ; 5-hydroxyindoleacetic acid (5-HIAA) ; Tryptophan (TRP) ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and tryptophan (TRP) were measured in the CSF obtained from the basal cistern of 20 patients, who had undergone surgical obliteration of bleeding aneurysms within 3 days after subarachnoid haemorrhage (SAH). The concentrations of these substances, which were assayed by high performance liquid chromatography (HPLC), were the highest on days 3 or 4, and thereafter showed a gradual decrease with an increase in time. The cisternal CSF in patients who had severe pre-operative clinical grades of SAH or vasospasm contained relatively higher concentrations of HVA, 5-HIAA and TRP than those contained in patients who did not. It is proposed that SAH stimulates the release of monoamines from the brain with the resultant extracellular accumulation of their metabolites and their diffusion into CSF during the acute stage. This stimulatory effect of SAH on the brain monoamine system may be consistent with those previously reported in cases of cerebral haemorrhage or infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02076018
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  • 9
    Electronic Resource
    Electronic Resource
    Femtosecond streak tube (1987)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 932-938 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new design concept of a streak tube is conceived to obtain femtosecond temporal resolution. It is based on four factors as follows. First, in order to decrease the photoelectron transit time spread, one must investigate how high electric field is practically usable near the photocathode. It is found that the value can be increased up to ∼6 kV/mm and this is used as a design value. Second, as the other method to decrease the photoelectron transit time spread, an electromagnetic focusing method must be adopted because there is no region similar to the focusing section of an electrostatic focusing type where the electric potential is low. Third, the focusing magnetic field should be located in a limited region to obtain a very high sweep speed of ∼2×108 m/s. And fourth, in the operation, a special readjustment of the focusing magnetic field should be performed to compensate the photoelectron beam defocusing caused by the very rapid transient deflection field. Based on the above, a new streak tube has been designed, manufactured, and tested. The limiting temporal resolution of ∼400 fs has been predicted theoretically and the value less than ∼500 fs has been experimentally produced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1139665
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization of Functional Receptors for Vasoactive Intestinal Peptide in Bovine Cerebral Arteries (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: This study reports the characterization of receptors for vasoactive intestinal peptide (VIP) on membranes prepared from bovine cerebral arteries. By use of HPLC we prepared two purified monoiodinated VIP radioligands with nearly equivalent cerebral vasorelaxant potency as native VIP, [Tyr(125I)10] VIP and [Tyr(125I)22] VIP. The former resulted in a higher proportion of specific binding to arterial membranes than the latter and was therefore thought to be the superior radioligand for receptor characterization. The binding of [Tyr(125I)10]VIP to cerebral arterial membranes was saturable, specific, reversible, and dependent on time and temperature. Scatchard analysis suggested the presence of a high- and a low-affinity binding site with KD values of 0.2 and 11 nM and receptor concentrations of 79 and 737 fmol/mg of protein, respectively. The dose-response curves for binding to the VIP receptor by the VIP-homologous peptides PHI, PHM, and rat growth hormone-releasing factor (GRF) were very similar to their dose-response curves for relaxation of cerebral arteries. The order of potency was VIP 〉 PHM 〉 PHI 〉 rat GRF. It is suggested that the characteristics of the vascular VIP binding sites and the close correlation between the binding and vasorelaxant properties of VIP and its related peptides argue for the vascular binding sites being functional receptors for VIP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb04077.x
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