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  • 1
    Electronic Resource
    Electronic Resource
    Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 535-540 
    Details
    ISSN: 1432-1041
    Keywords: spironolactone ; thiazides ; digitalis ; congestive heart failure ; arterial hypertension ; skeletal muscle potassium ; serum potassium ; skeletal muscle magnesium ; serum magnesium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542411
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of triameterene on serum and skeletal muscle electrolytes in diuretic-treated patients (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 577-579 
    Details
    ISSN: 1432-1041
    Keywords: diuretics ; triamterene ; magnesium ; potassium ; plasma ; skeletal muscle ; hydrochlorothiazide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (〉1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy. The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls. Thus, the combination of triameterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542490
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue (1985)
    Springer
    Journal of neural transmission 61 (1985), S. 253-264 
    Details
    ISSN: 1435-1463
    Keywords: Human brain ; post-mortem ; agonal state ; lactic acid ; pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Measurement of the frontal cortex and the medulla oblongata pH at autopsy revealed that those brains from individuals who died after long terminal phase had lower pHs than those who died quickly. These low pHs (pH 6.0–6.5) corresponded to lactic acid concentrations (20–25 mM) which are known to be neurotoxic. The cerebrospinal fluid pH and blood pH correlated with the cortical pH. The significance of these observations to the study of the biochemistry and histology on post-mortem human brain tissue and their possible clinical relevance are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01251916
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Physostigmine restores3H-acetylcholine efflux from Alzheimer brain slices to normal level (1986)
    Springer
    Journal of neural transmission 67 (1986), S. 275-285 
    Details
    ISSN: 1435-1463
    Keywords: Post mortem ; 3H-acetylcholine ; release ; physostigmine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A technique was developed, which made it possible to study thein vitro release of3H-acetylcholine (3H-ACh) from human post mortem brain tissue, collected with short post-mortem delay (2,5–22 hours), both from controls and patients with Alzheimer's disease (AD/SDAT). The tritium (3H) release was investigated during potassium stimulation, and AD/SDAT cortical slices were found to release a decreased amount of3H compared to control brain slices. Physostigmine, 10−5 and 10−4 M, has no significant effect on the release of3H from control slices, while physostigmine 10−4 M increased the evoked release from AD/SDAT brain slices over threefold, nearly to the control level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243353
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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