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  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Keywords HIV protease inhibitors ; lipodystrophy syndrome ; diabetes mellitus ; insulin resistance ; insulin signalling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Patients treated with human immunodeficiency virus-1 protease inhibitors often develop impaired glucose tolerance or diabetes, most likely due to an induction of insulin resistance. We therefore investigated whether the protease inhibitor indinavir alters insulin signalling. Methods. We incubated HepG2 cells for 48 h without or with indinavir (100 μmol/l). Subsequently 125I-insulin binding to the cells and the effects of insulin stimulation on insulin-receptor substrate-1-phosphorylation, association of phosphatidylinositol 3-kinase with insulin-receptor substrate-1 and Akt-Thr308-phosphorylation were measured. Results. In cells not exposed to indinavir, insulin (100 nmol/l) led to rapid increases of insulin-receptor substrate-1-phosphorylation, association of phosphatidylinositol 3-kinase with insulin-receptor substrate-1 and Akt-phosphorylation during the first 75 s, followed by subsequent decreases. In indinavir-treated cells, these insulin-stimulated increases during the first 75 s were reduced by 30–60 % and this was not associated with alterations in cell number or viability, insulin binding to the cells or cellular insulin-receptor substrate-1-content. Conclusion/interpretation. Effects of indinavir on initial insulin signalling could cause, or contribute to, the metabolic effects of human immunodeficiency virus-1 protease inhibitors. [Diabetologia (2000) 43: 1145–1148]
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Keywords Insulin receptor inhibition, tyrosine kinase activity, serine phosphorylation, protein kinase C.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Inhibition of the signalling function of the human insulin receptor (HIR) is one of the principle mechanisms which induce cellular insulin resistance. It is speculated that serine residues in the insulin receptor β-subunit are involved in receptor inhibition either as inhibitory phosphorylation sites or as part of receptor domains which bind inhibitory proteins or tyrosine phosphatases. As reported earlier we prepared 16 serine to alanine point mutations of the HIR and found that serine to alanine mutants HIR-994 and HIR-1023/25 showed increased tyrosine autophosphorylation when expressed in human embryonic kidney (HEK) 293 cells. In this study we examined whether these mutant receptors have a different susceptibility to inhibition by serine kinases or an altered tyrosine kinase activity.¶Methods. Tyrosine kinase assay and transfection studies.¶Results. In an in vitro kinase assay using IRS-1 as a substrate we could detect a higher intrinsic tyrosine kinase activity of both receptor constructs. Additionally, a higher capacity to phosphorylate the adapter protein Shc in intact cells was seen. To test the inhibition by serine kinases, the receptor constructs were expressed in HEK 293 cells together with IRS-1 and protein kinase C isoforms β2 and θ. Phorbol ester stimulation of these cells reduced wild-type receptor autophosphorylation to 58 % or 55 % of the insulin simulated state, respectively. This inhibitory effect was not observed with HIR-994 and HIR-1023/25, although all other tested HIR mutants showed similar inhibition induced by protein kinase C.¶Conclusion/interpretation. The data suggest that the HIR-domain which contains the serine residues 994 and 1023/25 is important for the inhibitory effect of protein kinase C isoforms β2 and θ on insulin receptor autophosphorylation. [Diabetologia (2000) 43: 443–449]
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1440
    Keywords: Acute myocardial infarction ; Plasma T3, rT3, T4, TSH ; Akuter Myocardinfarkt ; T3, rT3, T4 und TSH im Plasma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über das Verhalten der Schilddrüsenhormone und des TSH im Plasma von Männern im Frühstadium eines akuten Myocardinfarktes berichtet. T3 war bereits bei Klinikaufnahme erniedrigt und fiel weiter rapide ab. rT3 war bei Klinikaufnahme erhöht und erreichte nach 19 Stunden sein Maximum. T4 und TSH zeigten keine wesentlichen Veränderungen. Die Ergebnisse deuten daraufhin, daß es in der Frühphase des Myocardinfarktes zu einer raschen Verschiebung der Monodejodination des T4 zugunsten von rT3 anstelle von T3 mit rapidem. Abfall des T3 und Anstieg des rT3 im Blut kommt.
    Notes: Summary The changes of thyroid hormones and TSH in plasma of males in the early stage of myocardial infarction are described. Already on admission T3 was diminished and went on falling. On admission rT3 was elevated and reached its maximum after 19 hours. T4 and TSH did not show essential alterations. The results suggest that in the early stage of myocardial infarction a rapid shift of the monodeiodination of T4 to rT3 occurs instead of T3 with a quick decrease of T3 and increase of rT3 in the blood.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Ehrlich ascites-tumor ; Hypercaloric feeding ; Proliferation kinetics of tumor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oral feeding of mice with hypercaloric diets inhibited growth of a hyperdiploid Ehrlich ascites tumor significantly and modified proliferation kinetics of tumor cells if feeding started 7 days before tumor transplantation. Furthermore, the tumor take rate was significantly reduced. The 4 hypercaloric diets contained as main energy sources carbohydrates, or unsaturated fatty acids, or saturated fatty acids, or a mixture of these substrates. Inhibition of tumor growth was not observed if hypercaloric feeding started on the same day the tumor transplantation occurred. Tumor bearing animals lived significantly longer compared to controls if they are on a hypercaloric diet with unsaturated fatty acids as main energy source. Survival was not influenced by the time feeding started. That means that partial prevention of cachexia was the main reason for longer survival. Feeding with a diet poor in proteins led in both experimental sets to a statistically not significant shortening of the median survival time compared to controls.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 263 (2000), S. 99-101 
    ISSN: 1432-0711
    Keywords: Key words Leptin ; Menstrual cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Leptin is a cytokine involved in the regulation of food intake and fertility in rodents and in humans. No data exist about serum leptin serum levels during the spontaneous menstrual cycle. In this study 16 ovulatory cycles of endocrinologically normal volunteers were analyzed. Blood samples were taken on alternate days throughout the menstrual cycle for measurement of serum estradiol, progesterone, LH, FSH and leptin serum levels. No correlation of leptin values with estradiol values (r = 0.07) or progesterone values (r = 0.14) were seen. Mean leptin values during the luteal phase were significantly higher (16.67 ± 9.45 ng/mL) compared to the follicular phase (13.50 ± 8.75 ng/mL) (P 〈 0.02). A strongly positive correlation with the progression of the menstrual cycle could be seen (r = 0.91). The physiological significance of higher luteal phase leptin levels is unknown.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0942-0940
    Keywords: Chronic subdural haematoma ; surgery ; craniotomy ; clinical results ; computerized tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study 143 chronic subdural haematomas in 120 patients were analysed. 64% of patients were 60 years or older. All haematomas were operated on by slightly enlarged burr-hole craniotomy and closed system drainage for three days postoperatively. A history of trauma was present in 63%. Most frequent symptoms in the older patients were mental changes and impaired consciousness. Postoperative mortality (within one month after surgery) was 4%. After a follow-up period of up to 2.5 years after surgery, 69% were neurologically normal, 20% had only minor complaints or slight deficits. Postoperative CT scans showed a gradual re-expansion of the compressed brain during the 2–3 weeks following haematoma removal.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 836-838 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For the International Fusion Materials Irradiation Facility (IFMIF) scenario, a 140 mA deuterium beam in continuous wave (cw) mode with an atomic yield of above 85% is required. The normalized root-mean-square emittance should be less than 0.2 π mm mrad at the entrance of a RFQ. As part of a conceptual design for IFMIF, a new ion source has been developed and is tested at the Institut für Angewandte Physik in Frankfurt. The ion source is of the volume type with a tungsten cathode driving the discharge. Both cw and pulsed mode are possible and were studied. First experiments were carried out with deuterium. 80 mA deuterons with a D+ fraction of above 90% were extracted [A. Maser et al., Rev. Sci. Instrum. 67, 1054 (1996)]. In order to avoid neutron generation by the d–d reaction, hydrogen was used instead of deuterium later on. As far as the ion source and plasma production processes are concerned, the use of hydrogen instead of deuterium is equivalent because of their similar atomic shells. Recently, a 200 mA proton beam at 55 kV was extracted in cw mode (according to Child–Langmuir, 200 mA H+ corresponds to 140 mA D+) with a H+ fraction of 93%. This article will give a detailed description of the ion source and the essential experimental results. Especially, the influence of important physical parameters (such as discharge current and strength of the filter field) on the H+ fraction was studied. By using different kinds of auxiliary gases, the influence on the H+ fraction and the noise level were investigated, too. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 73 (2002), S. 1027-1029 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For the International Fusion Materials Irradiation Facility project (IFMIF) the Institut für Angewandte Physik at the University of Frankfurt is concerned with developing a high current proton/deuteron ion source. The 1999 "Frankfurt 200 mA Proton Source" is a volume type belonging to the high-efficient ion-sources family. This type of ion source has proven its capability to produce high-current ion beams of a single mass-to-charge ratio at very low-beam emittances. The arc discharge ion source delivers a 200 mA full beam (93% protons) at 55 keV with very high-beam intensities (outlet aperture 8 mm diam). Thus, the beam requirements for the IFMIF project are fulfilled. After having done the basic plasma investigation with a 127° cylinder spectrometer, the quality of the ion beam was a point of interest. Therefore, the beam emittance was measured with a conventional slit-grid measurement device. The goal was to measure the beam emittance at high-beam currents. The article will give a detailed description of the measurement of a 56 mA beam at 26 keV with 85% protons. Theoretical considerations of the emittance value, given by ion temperature and aberrations of the extraction system, allows an estimation of the emittance of a 170 mA at 55 keV proton beam. In a second step, an estimation of a postaccelerated 140 mA at 100 keV deuteron beam was completed. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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