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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied the effect of intravenous administration of leukotriene (LT) C4 or LTD., on airway responsiveness to histamine and airway wall thickening in guinea-pigs. Guinea-pigs were killed and the lungs were fixed in formalin. Slides from paraffin-embedded section of the lungs were stained and the airways that were cut in transverse section were measured by tracing enlarged images using a digitizer, Moreover, airway resistance (Raw) was determined by a pulmonary mechanics analyser and we calculated two indices, an index of airway wall thickening and the one of airway hyperresponsiveness to histamine, from changes of baseline-Raw and peak-Raw following intravenous administration of histamine before and after the intravenous administration of LTC4 or LTD4. The infusion of LTC4 or LTD4 induced an increase of the relative thickness of the airway wall in peripheral bronchi demonstrable by the histological examination. In analysis of airway function, intravenous administration of LTC4 or LTD4 induced airway hyperresponsiveness to histamine with airway wall thickening. The LTC4 and LTD4 receptor antagonist ONO-1078 inhibited these effects of LTC4 and LTD4, suggesting LTC4 and LTD4 may induce airway wall thickening and airway hyperresponsiveness through LTC4 and LTD4 receptors in the airways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb02729.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of potassium iodide, colchicine and dapsone on the generation of polymorphonuclear leukocyte-derived oxygen intermediates (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 107 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of potassium iodide, colchicine and dapsone on the in vitro generation of polymorphonudear leukocyte (PMN)-derived oxygen intermediates were investigated. These three drugs have beneficial effects on those conditions in which PMNs play an important pathogenetic role. Three oxygen intermediates, superoxide anion (O2−), hydrogen peroxide (H2 O2), hydroxyl radical (OH·) and chemiluminescence were included in assay studies. Dose response studies were performed with therapeutic doses of the drugs (10 μM–1 mM). We found that both potassium iodide and dapsone significantly suppressed the generation of oxygen intermediates, except for O2−. Colchicine decreased OH · production.Our results show that these agents to some extent exert their anti-inflammatory effects by interfering with the PMN-dependent production of oxygen intermediates, thus conferring protection from auto-oxidative tissue injury. This may account for their clinical efficacy in many PMN-mediated dermatological diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb00340.x
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  • 3
    Electronic Resource
    Electronic Resource
    Systemic sclerosis terminating as systemic necrotizing angiitis (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 57-year-old woman with systemic sclerosis (SSc) who died suddenly, following a haemoptysis. At post-mortem, systemic necrotizing angiitis of small vessels was observed in several organs. Necrotizing angiitis has been reported as a rare complication of systemic sclerosis, and is usually lethal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb03344.x
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  • 4
    Electronic Resource
    Electronic Resource
    A scleroderma-like variant of recessive dystrophic epidermolysis bullosa? (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 17-year-old Japanese girl with typical clinical features of recessive dystrophic epidermolysis bullosa (RDEB). She had initially been diagnosed as suffering from systemic sclerosis because her skin became sclerotic at the age of 21 months, and there was no apparent blister formation. She subsequently developed severe dystrophic skin changes. However, there was histological evidence of subepidermal cleavage, diminished basement membrane zone immunohistochemical reactivity to anti-type VII collagen monoclonal antibody, and markedly decreased numbers of anchoring fibrils on electron microscopy. Although both the clinical and laboratory findings support a diagnosis of RDEB, we cannot exclude the possibility that our patient might represent a new clinical entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb00494.x
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  • 5
    Electronic Resource
    Electronic Resource
    Disaccharide analysis of the skin glycosaminoglycans in patients with Werner's syndrome (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 19 (1994), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The disaccharide content of the chondroitinase-digestible glycosaminoglycans (GAGs) extracted from 6–mm skin punch biopsies from the atrophic and sclerotic skin of two patients with Werner's syndrome (WS) were determined using high-performance liquid chromatography after 1–phenyl-3–methyl-5–pyrazolone labelling. The total amount of main disaccharides was significantly decreased in the atrophic lesions of WS. In the atrophic forearm skin, the decrease in the main disaccharide unit of hyaluronic acid, ΔDi-HA, and the increase in the ratio of the main disaccharide unit of dermatan sulphate, ΔDi-4S, to ΔDi-HA were significant vs. normal control (P 〈0.01 and 0.05, respectively). The sclerotic skin showed an increase in ΔDi-4S (DS) (P 〈 0.05) and a decrease in ΔDi-HA (P 〈 0.02) compared with normal controls, as well as a significantly higher ratio of ADi-4S (DS)/ΔDi-HA compared with normal controls (P 〈 0.0002) and systemic sclerosis patients (SSc; P 〈 0.02). No other statistical difference was found in the amount of each main disaccharide unit between the sclerotic skin of WS and SSc. Histological examination revealed that the atrophic skin showed thinning of the dermis with a slight increase of fine collagen bundles, whereas the sclerotic skin demonstrated a thickened dermis with prominent deposition of fine collagen bundles in the deep dermis. In SSc, thickening of the whole dermis, composed of hyalinized or swollen collagen bundles, was found. These results suggest mat alterations of disaccharide components in WS may differentiate the atrophic skin changes from the sclerotic skin changes, while the mechanisms for abnormal fibrosis remain to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1994.tb01253.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of thalidomide on the generation of oxygen intermediates by zymosan-stimulated normal polymorphonuclear leukocytes (1982)
    Springer
    Archives of dermatological research 274 (1982), S. 363-367 
    Details
    ISSN: 1432-069X
    Keywords: Thalidomide ; Oxygen intermediates (OI) ; Polymorphonuclear leukocyte (PMN) ; Erythema nodosum leprosum (ENL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403742
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  • 7
    Electronic Resource
    Electronic Resource
    The fate of experimental cutaneous candidiasis in guinea pigs under the suppressed polymorphonuclear leukocyte chemotaxis by colchicine (1981)
    Springer
    Archives of dermatological research 271 (1981), S. 373-380 
    Details
    ISSN: 1432-069X
    Keywords: Candida albicans ; Polymorphonuclear leukocyte ; Colchicine ; Chemotaxis ; Candida albicans ; polymorphonucleäre Leukocyte ; Colchicin ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Experimentelle Hautinfektion mit Candida albicans bei Meerschweinchen wird histologisch durch intensive epidermische Akkumulation der polymorphonuclearen Leukocyten (PMN) charakterisiert. Um die Rollen der PMN in vivo zu studieren, injizierten wir i.p. 250 μg Colchicin/kg, einen potenten Inhibitor der PMN-Chemotaxis, und beobachteten Einflüsse der reduzierten PMN-Migration bei der experimentellen Candidiasis, mit spezialem Interesse am Eliminationsverlauf des Organismus. Es gab bei der Colchicin-behandelten Gruppe eine signifikante Verzögerung mit der Abnahme der epidermischen PMN-Infiltration und der Verlängerung des sichtbaren Schuppenprozesses. Unsere Daten zeigen, daß die Verzögerung der epidermischen PMN-Migration dem Verschwinden des Organismus aus der infizierten Haut entspricht und daß PMN in der Abwehr gegen die Candida-Infektion, besonders in dem Eliminationsverlauf, eine wichtige Rolle spielen.
    Notes: Summary Experimental cutaneous Candida albicans infections in guinea pigs are histologically characterized by intense epidermal polymorphonuclear leukocyte (PMN) accumulation. To study the role of PMNs in vivo, we injected 250 μcolchicine/kg i.p., a strong inhibitor of PMN chemotaxis, and observed the influence of reduced PMN migration in experimental cutaneous candidiasis with special interest in the elimination course of the organisms. There was a significant delay in the clearance of the organisms in the colchicine-treated group with decreased epidermal PMN infiltration and prolonged visible scaling process. Our data suggest that the delay of epidermal PMN migration parallels the disappearance of the organisms from the infected skin and that PMNs play an important part in defense against candida infections especially in the elimination process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406681
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  • 8
    Electronic Resource
    Electronic Resource
    γδ T-cell receptor-positive cells of human skin. II. Appearance in delayed-type hypersensitivity reaction (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 436-440 
    Details
    ISSN: 1432-069X
    Keywords: γδ TCR+ cells ; Human skin ; Immunohistochemistry ; Delayed-type hypersensitivity reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the distribution and involvement of human γδ T-cell receptor-positive (TCR+) cells in delayed-type hypersensitivity reactions of the skin, we examined the occurrence and kinetics of γδ TCR+ cells during skin reactions of allergic contact dermatitis. In normal human skin sections, γδ TCR+ cells were scarce. In allergic contact dermatitis from DNCB, increased γδ TCR+ cells were observed both in the epidermis and in the dermis from 48 h after the challenge. Most of the γδ TCR+ cells were TCRδ1+ δTCS1− BB3+ TiγA+ (Vδ1− Vδ2+ Vγ9+). The percentage of γδ TCR+ cells in the peripheral blood remained unchanged and a few γδ TCR+ cells in the skin lesions proliferated in situ. It is suggested that the γδ TCR+ cells in skin lesions of allergic contact dermatitis may not be involved in initiation of delayed-type hypersensitivity but may have some other roles responding to factors induced in the reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372140
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  • 9
    Electronic Resource
    Electronic Resource
    The changes in the binding capacity of testosterone-oestradiol binding globulin (TeBG) following castration and DES-D administration in patients with prostatic carcinoma (1982)
    Springer
    Urological research 10 (1982), S. 119-122 
    Details
    ISSN: 1434-0879
    Keywords: TeBG ; Free testosterone ; Acid phosphatase ; Prostatic carcinoma ; Castration and DES-D therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The levels of plasma testosterone, testosterone-oestradiol binding globulin (TeBG) and total serum acid phosphatase (TSAP) following antiandrogenic hormone therapy were investigated in 17 patients with prostatic carcinoma. The low levels of plasma total and free testosterone induced by castration decreased further after diethylsitlboestrol diphosphate (DES-D) administration. Plasma TeBG binding capacity after castration was 118.9% of the pre-treatment level and increased to 193.9%, 204.0% and 212.7% at 1, 2 and 3 weeks after DES-D dosing. The in vitro binding of 3H-testosterone to TeBG was not influenced in the presence of DES-D or stilboestrol. Clinical response following the DES-D therapy was associated with a decrease in the levels of TSAP. A significantly inversed correlation was found between the decrease in TSAP and increase in TeBG at completion of DES-D therapy. These results suggest that the high binding capacity of TeBG lowers the biologically active fraction of testosterone and thus may produce clinical effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255953
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  • 10
    Electronic Resource
    Electronic Resource
    Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 162-166 
    Details
    ISSN: 1432-069X
    Keywords: Azelaic acid ; Neutrophil functions ; Free radical generation ; Acne inflammation ; Hyperpigmentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been shown that acne, hyperpigmentation and lentigo malignant are more or less related pathogenetically to reactive oxygen species (ROS). It has recently been reported that azelaic acid is effective in treating these conditions and that it possesses anti-enzymatic and anti-mitochondrial activity, including cytochrome-P450 reductase and 5α-reductase in microsomal preparations with nicotinamide adenine dinucleotide phosphate (NADPH). We therefore investigated the effects of azelaic acid on human neutrophil functions, such as chemotaxis, phagocytosis and ROS generation. ROS generation in a cell-free system was also assessed. The results revealed that neutrophil chemotaxis and phagocytosis as well as ROS generated in a xanthine — xanthine-oxidase system were not significantly changed in the presence of azelaic acid. However, azelaic acid markedly decreased O 2 − and OH generated by neutrophils. It may be concluded that the reported clinical effectiveness of azelaic acid is partly due to its inhibitory action on neutrophil-generated ROS, leading to a reduction both in oxidative tissue injury at sites of inflammation and in melanin formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372056
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