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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Physics and chemistry of minerals 10 (1983), S. 16-20 
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract Shock-loading experiments are performed on single-crystal specimens of BaZnGeO4 (BZG) between 13 and 51 GPa using a propellant gun and a two-stage light gas gun. Observation by an optical microscope reveals that all the shocked specimens are made of fragmented blocks of 10 ∼ 100 μm in size. X-ray analyses indicate that the samples shocked to pressures above 41 GPa became a polycrystalline state of BZG with a weakly textured structure. A small amount of dissociation products of BaGeO3 (pyroxene type) and ZnO (wurtzite type) are detected in this pressure range. Between 27 and 19 GPa, a new phase which is thought to be produced by considerable deformations in the ring structure consisting of ZnO4 and GeO4 tetrahedra is observed. Below 19 GPa, shocked specimens are brought into a well aligned mosaic structure, but no significant change in the crystal structure is detected.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Physics and chemistry of minerals 14 (1987), S. 345-349 
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract Samples of synthetic diaplectic anorthite glass (38 GPa shock pressure), thermal glass and synthetic anorthite crystals were investigated using infrared spectral methods at one atmosphere and high pressures (near 4 GPa). Band positions and pressure derivatives for the Si-O asymmetric modes in the region 1,300–900 cm−1 indicate that the diaplectic glass has more structural similarities with the crystalline material than with thermal glass even though the overall infrared spectral characteristics suggest a glassy state.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 395 (1982), S. 257-271 
    ISSN: 1432-2307
    Keywords: Necrotizing lymphadenitis ; Histiocytic lymphadenitis ; Lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-seven cases of an unusual necrotizing lymphadenitis previously described only in Japan are reported as occurring in West Germany (23 cases), Iran (1 case), Italy (1 case), Korea (1 case) and Spain (1 case). The lesion frequently develops in the cervical lymph nodes of young women. It is characterized by infiltration of the cortex and/or paracortex by large collections of proliferating histiocytes and is devoid of granulocytes. Complete or, more often, incomplete necrosis of lymphoid tissue is seen in all cases. In cases with incomplete necrosis, the histiocytes are interspersed with pyknotic cells and nuclear debris. Based on the histological findings, the term “histiocytic necrotizing lymphadenitis without granulocytic infiltration” is proposed. Lesions to be considered in a differential diagnosis are malignant histiocytic neoplasms and necrotizing lymphadenitis with granulocytic infiltration, which is seen in lupus erythematosus and bacterial infections. The aetiology of histiocytic necrotizing lymphadenitis without granulocytic infiltration is still unclear. Some clinical and histological features indicate the possibility of an underlying viral infection.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1450-1451 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The photoreceptor cells in the pineal organ of the Japanese common newt are similar to typical vertebrate photoreceptors. It is supposed that the cells are responsible for the entrainment of locomotor rhythms as a consequence of their response to light.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Hypertension ; streptozotocin ; animal model ; spontaneously hypertensive rats ; Type 2 (non-insulin-dependent) diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to develop an animal model of Type 2 (non-insulin-dependent) diabetes with persistent hypertension. Male spontaneously hypertensive rats were treated with 25.0, 37.5, 50.0, 62.5 or 75.0 mg/kg of streptozotocin given intraperitoneally at 2 days of age and maintained for 12 weeks. In the rats which received 50.0 mg/kg or more streptozotocin, overt hyperglycaemia gradually and consistently developed following incomplete recovery from an initial hyperglycaemia. Compared to vehicle-treated controls, body weight gain in these animals did not differ for the first 8 weeks; thereafter, it was slightly but significantly (p 〈 0.05) reduced. The animals treated with 25.0 or 37.5 mg/kg streptozotocin developed mild to moderate hyperglycaemia, but their body weight gain was similar to controls. The relationships between streptozotocin dose and metabolic responses (plasma glucose, glycosylated haemoglobin, urinary glucose, food intake, etc.) were clearly demonstrated. Systolic blood pressure rose with progressing age in both controls and streptozotocin-treated rats, irrespective of dosage or metabolic response. This new rat model of Type 2 diabetes associated with persistent hypertension may be useful in studying these combined effects on small and large vessels.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; hypertension ; nephropathy ; urinary protein ; streptozotocin ; N-acetyl-β-D-glucosaminidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We designed the present study to clarify whether the development of nephropathy was accelerated by a combination of hypertension and non-insulin-dependent diabetes. Spontaneously hypertensive rats with non-insulin-dependent diabetes induced by neonatal streptozotocin treatment (25.0–75.0 mg/kg) were separated into severely or mildly diabetic groups according to their non-fasting plasma glucose levels at 12 weeks of age and the findings were compared with the data on a control group treated with citrate buffer alone. The natural courses of urinary excretion rate of total protein, the molecular composition by sodium dodecyl sulfate polyacrylamide gel electrophoresis with laser desitometer and N-acetyl-β-D-glucosaminidase were measured in the three groups from 12 weeks until 36 weeks of age. Total urinary protein in the control group decreased with age (p〈0.05), while in the mildly diabetic group changes were nil; in the severely diabetic group, however, the excretion rates of total urinary protein and high molecular weight protein consistently and progressively increased with age (p〈0.05). The low molecular weight protein continuously decreased with age in the mildly diabetic and control groups (p〈0.05), while in the severely diabetic group there was no decrease after 28 weeks of age. The urinary N-acetyl-β-D-glucosaminidase markedly increased (p〈0.05) in the severely diabetic group throughout the period compared with findings in the control group, but drastically decreased (p〈0.05) in the mildly diabetic group with age. There were significant correlations between the mean glycosylated haemoglobin levels and all the urinary parameters measured (p〈0.05). These observations suggest that development of nephropathy is accelerated by the glycaemic level in hypertensive rats. This new model should be appropriate for studying the combined effects of hypertension and diabetes mellitus on the kidney.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1076
    Keywords: Ornithine transcarbamylase deficiency ; Heterozygote ; Immunohistochemical analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Females heterozygous for the X-linked urea cycle disorder, ornithine transcarbamylase (OTC) deficiency have a significant risk of developing hyperammonaemia. Diagnosis of this genetic defect in a proband is the essential starting point for family studies. By an immunohistochemical analysis of the liver specimens fixed in 10% formalin, we confirmed heterozygous status for OTC deficiency in two female patients, a 15-year-old girl and a 2-year-old girl, who died of hyperammonaemia. Since most affected males lack cross reactive materials (CRM), an immunochemical analysis should be useful for the diagnosis of most heterozygous females.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 5 (1989), S. 41-47 
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The stiffness matrix of a 4-nodes insoparametric element for the two dimensional finite element analysis is evaluated using the symbolic mathematics systems, called REDUCE. The results are compared with those obtained by numerical integration. It is shown that there exist some differences between the numerical values of the stiffness matrix by symbolic and numerical integrations. The differences become smaller as the integration points of the numerical integration increases, which means that the results obtained by symbolic integration give accurate values. The stiffness matrix in elastic-plastic state is also evaluated using symbolic mathematics, and it is shown that the results agree with those obtained by numerical integration. It is pointed out that there is a possibility to decrease the CPU time by using the symbolic mathematics system.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 33 (1989), S. 19-23 
    ISSN: 1432-1254
    Keywords: Temperature change ; Immune response ; Male mice ; Corticosterone ; Physiological adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract We investigated the time relationship between ambient temperature change and antigen stimulation on immune responses to sheep red blood cells (SRBC) and polyvinylpyrrolidone (PVP) in mice. In the case of a shift from comfortable (25°C) to cold (8°C) temperatures, suppression in the number of splenic plaque-forming cells (PFC) took place mainly when the shift was done between 1 day before and 2 to 4 days after immunization. The suppression of the PVP response lasted for up to a maximum of 6 days when mice were transferred 1 day before immunization. In the case of a temperature shift from 25° to 36.5°C, the suppressive effect was found when the temperature shift was done between 4 days before and 2 days after immunization. The effect lasted longer than that of the temperature shift to cold, i.e., at least 9 days after the temperature shift. Blood corticosterone levels after the temperature shifts corresponded to changes in the immune responses: elevation of the blood corticosterone levels was observed for only the first 3 days after a temperature shift to 8°C but for 10 days after a temperature shift to 36.5°C during the period time of the experiment. These result suggested that blood corticosterone level contributes to the duration of the effects of temperature shifts on immune responses of mice. Furthermore, it appeared that the early stage of the immune response is more susceptible to temperature shifts than the later stage. To explain these results, the terms “effective period” in the course of physiological adaptation to changed ambient temperature and “susceptible period” in the course of the immune response, were proposed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Type of Medium: Electronic Resource
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