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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 138 (1982), S. 162-165 
    ISSN: 1432-1076
    Keywords: 25-Hydroxyvitamin D ; 24,25-Dihydroxyvitamin D ; Steroid-induced bone complications ; Nephrotic syndrome ; Relapser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of prednisone therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)2D] was investigated in 16 children with nephrotic syndrome. These serum levels were significantly lower in patients before prednisone therapy than in age- and seasonmatched normal subjects. Patients receiving daily prednisone therapy had lower serum levels than those receiving alternateday prednisone therapy at the time when the total amounts of the steroid administered attained 1,500 or 2,000 mg/m2 of body surface area. Daily doses of 40 mg/m2 of prednisone for 3 days caused a significant decrease in serum 25(OH)D levels. Withdrawal of the steroid for 4 consecutive days was followed by a significant recovery of the serum levels. These results suggest that alternate-day prednisone therapy rather than daily treatment should be used in clinical practice to help maintain normal vitamin D metabolism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 35 (1983), S. 82-86 
    ISSN: 1432-0827
    Keywords: Osteoclasts ; Bone marrow culture ; Hydrocortisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The generation of osteoclasts in cultures of cat bone marrow was completely inhibited for 4 weeks with 10−6M hydrocortisone (HC) and partially inhibited with 10−7 to 10−9M in a dose-dependent fashion. This effect was completely reversible when cultures were exposed for only 2 weeks to 10−9 or 10−8M HC. However, cultures in which higher concentrations (10−7 to 10−5M) were maintained for the same period did not show complete recovery in terms of numbers of osteoclasts and number of nuclei per cell after withdrawal of HC, suggesting that precursor cells of osteoclasts were also damaged by HC. To study the effects of HC on osteoclasts already present in the cultures, 10−6M was added to 4-week-old untreated cultures. The number of osteoclasts decreased rapidly and a gross morphological response was also apparent (rounding of the cells leading to detachment from the substratum and inhibition of cell fusion), indicating that the generation as well as the survival of osteoclasts in vitro are sensitive to HC. The morphological changes observed under optical and electron microscopy correspond to those of the reported inactive form of osteoclasts, and suggest that their function may also be altered by HC.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 36 (1980), S. 127-128 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Decreased deformability, slightly increased suspension viscosity and retarded oxygen egress were observed in cholesterol-loaded, human erythrocytes. These functional changes resulted from the decreased membrane fluidity induced by cholesterol.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 36 (1978), S. 285-298 
    ISSN: 1432-0584
    Keywords: Aplastische Anämie ; Schwangerschaft ; Aplastic anemia ; Pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Our recent experience on six cases of aplastic anemia complicated with pregnancy is described. In addition, 43 similar cases were collected from the literature and reviewed to analyze some prognostic aspects of this relatively rare but potentially serious complication. Clinical and hematological data were treated to extract some clinically meaningful factors in relation to the success and failure of pregnancy. Among initial hematological parameters, no significant difference was found between successful and unsuccessful cases with an exception of hemoglobin concentration. The patients diagnosed as aplastic anemia prior to conception demonstrated an better outcome of pregnancy as well as survival rate of mother when compared with those diagnosed during pregnancy. Mortality has apparently improved after the late 1950's. Success rate of pregnancy before 1958 was 21% while it was 67% and 71% in the era of 1959–1969 and after 1970, respectively. However, hemorrhage and infection remained to be two major causes of maternal death in both eras. Based on these observations, the currently recommendable attitude to this complication is discussed.
    Notes: Zusammenfassung Berichte über Schwangerschaften bei aplastischer Anämie oder das Auftreten einer aplastischen Anämie in der Schwangerschaft sind selten. Anhand von 6 eigenen derartigen Fällen und von 43 Fällen aus der Literatur wurden die hämatologischen und klinischen Befunde in Hinsicht auf ihre prognostische Bedeutung untersucht. Bei den hämatologischen Parametern war lediglich die Hämoglobinkonzentration von prognostischer Bedeutung. Bei Auftreten der aplastischen Anämie vor der Schwangerschaft war die Prognose besser als bei Auftreten während der Schwangerschaft. Der Prozentsatz der erfolgreich ausgetragenen Schwangerschaften stieg von 21% vor 1958 auf 67% in der Zeit von 1959 bis 1969 und auf 71% nach 1970. Blutungen und Infektionen waren die beiden wichtigsten mütterlichen Todesursachen. Aus den Ergebnissen ist abzuleiten, daß bei ausgeprägtem Kinderwunsch und gutem Allgemeinzustand von einer Schwangerschaft bei bestehender aplastischer Anämie nicht immer abgeraten werden muß und daß andererseits bei einer progredienten aplastischen Anämie, die in der Schwangerschaft auftritt, möglichst früh eine Schwangerschafts-unterbrechung erfolgen muß.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The thin-layer chromatographic behavior of 57 metals on a weakly acidic cation exchanger, carboxymethyl (CM) cellulose, has investigated systematically in sulfuric acid (0.01–1.0 M) and the acidic ammonium sulfate media. Thin-layer plates of a microcrystalline cellulose, Avicel SF, were also used to compare with the chromatographic behavior of the metals in the acidic sulfate system. The Rf values obtained for many metals tested on CM-cellulose plates increase with increasing concentration of sulfuric acid. Most of metals tested are distributed chromatographically on the CM-cellulose in the low acid concentration. The characteristic retention of many metals, including sulfato-complexes forming metals, on the CM-cellulose can be observed in ammonium sulfate solutions of a low concentration of the acid. Useful multicomponent separations of analytical interest on CM-cellulose layers are presented to demonstrate the use of Rf measurements for predicting separations in the acid and the acidic ammonium sulfate systems.
    Type of Medium: Electronic Resource
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