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  • 1
    Electronic Resource
    Electronic Resource
    The sensitive period for ototoxicity of kanamycin in mice: Morphological evidence (1983)
    Springer
    European archives of oto-rhino-laryngology and head & neck 238 (1983), S. 217-223 
    Details
    ISSN: 1434-4726
    Keywords: Kanamycin ; Cochlea damage ; Audiogenic seizures ; Sensitive period for ototoxicity ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ototoxicity of kanamycin was investigated in mice treated with the drug either from 6 to 9, 10 to 13, or 15 to 18 days of age. The results showed extensive damage to the outer-hair-cell (OHC) receptors of the cochlea in the 10–13-day group; some less severe damage to the OHC was found in the 6–9-day group, and little damage was observed in the 15–18 day group. The present finding is consistent with the view that the mouse cochlea is most vulnerable to the ototoxic effect of kanamycin during the period of its rapid development, i.e., between 10 and 13 days of age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453932
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid development of acoustic trauma-induced audiogenic seizure risk in 3 strains of seizure-resistant mice (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1194-1196 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Audiogenic seizure risk can be induced in genetically seizure resistant mice by exposure to an intense noise a few days prior to testing for seizure. This experiment demonstrates that the priming induced seizure risk can develop within 6–16 h after priming. It was argued that this finding suggested an alternative hypothesis of priming involving peripheral auditory mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01976123
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  • 3
    Electronic Resource
    Electronic Resource
    The sensitive period for induction of susceptibility to audiogenic seizures by kanamycin in mice (1981)
    Springer
    European archives of oto-rhino-laryngology and head & neck 232 (1981), S. 215-220 
    Details
    ISSN: 1434-4726
    Keywords: Ototoxizität ; Kanamycin ; Empfindlichkeit ; Maus ; audiogene Anfälle ; Ototoxicity ; Kanamycin ; Sensitive period ; Mice ; Audiogenic seizures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary It has been found that administration of kanamycin (400 mg/kg daily) for 5 days was highly effective in inducing susceptibility to audiogenic seizures in BALB/c mice, if the drug was administered between the age of 10–14 postnatal days. The same drug dosage administered between the age of 5–9, 15–19, or 20–24 postnatal days was found to be ineffective. Since induction of seizure susceptibility is highly correlated with the degree of cochlear damage produced by either ototoxic drugs or noise, it was suggested that the age of 10–14 postnatal days could be the most sensitive period for the ototoxic effect of kanamycin.
    Notes: Zusammenfassung Kanamycin in einer Dosis von 400 mg/kg täglich über 5 Tage bewirkt eine deutliche Empfindlichkeitssteigerung für audiogene Anfälle bei BALB/c-Mäusen, wenn das Medikament zwischen 10. und 14. postnatalem Tag verabreicht wird. Kanamycin in gleicher Dosis hat aber keinen Effekt, wenn es zwischen 5.–9., 15.–19. oder 20.–24. postnatalem Tag gegeben wird. Da die Erhöhung der Anfälligkeit für audiogene Anfälle einen deutlichen Zusammenhang mit dem Grad von Cochleaschaden durch ototoxische Medikamente oder Lärm hat, wird angenommen, daß der 10.–14. postnatale Tag die empfindlichste Periode für den ototoxischen Effekt des Kanamycins darstellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00457444
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  • 4
    Electronic Resource
    Electronic Resource
    New epoxy resins. II. The preparation, characterization, and curing of epoxy resins and their copolymers (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 27 (1982), S. 3289-3312 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A polymer having high aromaticity and/or cyclic ring structures in the chain backbone usually gives high heat resistance and flame resistance. Five glycidyl ether-type epoxy resins are prepared from bisphenol A (DGEBA), 9,9-bis(4-hydroxyphenyl)fluorene (DGEBF), 3,6-dihydroxyspiro-[fluorene-9,9′-xanthane] (DGEFX), 10,10-bis(4-hydroxyphenyl) anthrone (DGEA), and 9,9,10,10-tetrakis(4-hydroxyphenyl)anthracene (TGETA) in order to study structure-thermal stability-flame resistance property relationships. In this study, trimethoxyboroxine (TMB) and diaminodiphenylsulfone (DDS) are employed as the curing agents. The char yield at 700°C under a nitrogen atmosphere and the glass transition temperature (Tg) for the uncured resins decrease according to the sequence TGETA 〉 DGEFX 〉 DGEA 〉 DGEBF 〉 DGEBA. The Tg values for these cured epoxy resins are DGEBA 〈 DGEBF 〈 DGEFX 〈 DGEA. A Tg for the TGETA is not obtainable but would be expected to be the highest. The char yields at 700°C of these cured epoxy resins have the same trend as the uncured resins. DGEBF, DGEFX, DGEA, and TGETA added to the DGEBA system show increases in the char yield, Tg, and oxygen index with increasing concentration of these novel epoxy resins.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1982.070270909
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  • 5
    Electronic Resource
    Electronic Resource
    New epoxy resins. I. The stability of epoxy-trialkoxyboroxines triaryloxyboroxine systemCorrected proofs received January 28, 1982 (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 27 (1982), S. 1177-1190 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A polymer with high aromaticity and/or cyclic ring structures chain backbone usually has high heat, thermal, and flame resistance. Two diglycidyl ethers of bisphenols were prepared from 4,4′ isopropylidenediphenol (DGEBA) and 9,9-bis(4-hydroxyphenyl) fluorene (DGEBF) for evaluation. Four boroxines - trimethoxyboroxine (TMB), triethoxyboroxine (TEB), triisopropoxyboroxine (TIPB) and triphenoxyboroxine (TPB) - were used as the curing agents. DGEBA and DGEBF cured with various boroxines indicate that the trend for their respective glass transition temperature (Tg's), degradation temperatures (Td's), and gel fractions are TMB-cured epoxy ≈ TEB-cured epoxy 〈 TIPB cured epoxy 〈 TPB cured epoxy. The DGEBF system usually has a higher Tg, Td, gel fraction, oxygen index (OI), and char yield than the related DGEBA system. DGEBF/DGEBA (80/20 mol ratio) shows a synergistic effect in regard to char formation. This effect exists not only in the copolymer system but also in blended homopolymers of the separately cured resins. A modified mechanism for the polymerization of phenyl glycidyl ether (PGE) with TMB has been proposed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1982.070270407
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  • 6
    Electronic Resource
    Electronic Resource
    New epoxy resins. III. Application of fourier transform IR to degradation and interaction studies of epoxy resins and their copolymers (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 28 (1983), S. 1077-1091 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: In the Fourier transform infrared (FT-IR) study, diglycidyl ether of bisphenol A (DGEBA) did not show aldehyde or perester absorption when it was normally cured with trimethoxyboroxine (TMB) under a nitrogen atmosphere. Neither alumina nor gold surfaces would cause oxidation of the system. In air, alumina appeared to accelerate the oxidation when compared to gold. The cure of the epoxy in oxygen appeared to cause increased Claisen rearrangement when compared with the same cure in a nitrogen atmosphere. The DGEBA cured with TMB under air or nitrogen atmospheres showed differences in their degradation patterns. The TMB-cured DGEBA and diglycidyl ether of 9,9-bis(4-hydroxyphenyl) fluorene (DGEBF) copolymer had a higher degree of reaction and lower degradation than was shown by the synthetically generated spectra based on the FT-IR summation of the spectra of the respective homopolymers.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1983.070280314
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