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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A double Wind, placebo-controlled treatment with Antabuse® was carried out in 24 patients with hand eczema and nickel allergy. The amount of Antabuse® given was gradually increased from 50 to 200 mg daily. The maximum dose was given for ft weeks. During the treatment period, the dermatitis of 5 out of 11 patients in the group treated with Antabuse® healed, compared with 2 out of 13 in the group receiving the placebo. A statistical analysis was made of changes observed during the study, through the parameters: staling, frequency of flares, erythema, area involved and number of vesicles. Differences in results obtained with Antabuse® and the placebo were statistically significant only for the parameters scaling and frequency of flares (p 〈 0.05). The difference between the sums of parameters following the 2 forms of treatment was not statistically significant (p= 0.11). 2 patients treated with Antabuse® showed signs of hepatic toxicity; 1 of them had toxic hepatitis. No other significant side effects were seen.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 25 (1983), S. 231-234 
    ISSN: 1432-0428
    Keywords: Epidemiology ; insulin-treated diabetes ; prevalence ; heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 11973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were 〉 age 50 years and 42% and 36% of males and females, respectively, had a disease duration of 〈 10 years. The overall proportion of patients treated permanently with insulin from diagnosis was 85% and 79% in males and females, respectively, but within the subgroup of patients with current age 〈 30 years these proportions were 99% and 96%, respectively. Statistical analysis indicated that insulin-treated diabetes is a clinically heterogeneous group of diseases; thus, low age at onset combined with immediate and permanent insulin treatment delineate one subtype, while relatively high age at onset and late start and/or interruption of insulin treatment delineate other subtype(s). It is estimated that the proportion of patients with truly Type 1 (insulin-dependent) diabetes is 〉 50% in this cross-sectional population of insulin-treated patients.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Insulin-treated diabetes ; mortality ; regression analysis ; death certificates ; causes of death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 7-year follow-up study is reported on the prevalent population of all insulin-treated diabetic patients (n=1499) as of 1 July 1973 in the Funen County, Denmark. The analysis of mortality was based on data from 395 dead and the remaining 1104 living patients. Males had a significantly higher mortality than females and a lower age at onset was associated with a significantly higher mortality. An analysis of the causes of death revealed a higher than expected number of deaths in all categories studied, although the excess mortality was highest for diabetes mellitus itself and cardiovascular diseases. Diabetes mellitus was not notified on 15% of the death certificates, and this under-reporting varied according to duration of the disease and place of death. It is concluded that studies based solely on death certificates will underestimate the mortality of diabetes mellitus, and that further longitudinal studies of well-defined, population-based patient groups are needed to evaluate the determinants of mortality in diabetes.
    Type of Medium: Electronic Resource
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