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  • 1
    Electronic Resource
    Electronic Resource
    Omeprazole, a gastric ‘proton pump inhibitor’: Lack of effect on renal handling of electrolytes and urinary acidification (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 639-640 
    Details
    ISSN: 1432-1041
    Keywords: omeprazole ; H+/K+-ATPase ; ammonium chloride ; urinary acidification ; gastric acid secretion inhibitor ; renal electrolyte excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Omeprazole has previously been shown to be a potent inhibitor of gastric acid secretion in man. In a new study, oral omeprazole 60 mg/day was given to 8 healthy male subjects for 8 days. The daily urinary electrolyte output and urine pH in response to ammonium chloride were not significantly altered. This provides further support for the specificity of its action on gastric acid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543501
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oral pharmacokinetics of omeprazole (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 641-643 
    Details
    ISSN: 1432-1041
    Keywords: omeprazole ; gastric acid secretion ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of omeprazole from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543502
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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