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  • 1
    Electronic Resource
    Electronic Resource
    High concentration effects of ion implanted boron in silicon (1980)
    Springer
    Applied physics 22 (1980), S. 35-38 
    Details
    ISSN: 1432-0630
    Keywords: 61.70 Tm ; 66.30 Lw
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The diffusion behaviour of implanted boron in silicon was investigated using the10B(n,α)7 Li nuclear reaction. An anomalous behavior with a strong reduction of the diffusivity above an effective solubility limit at 1.5×1019, 6×1019, and 1.1×1020 cm−3 was found for annealing temperatures of 800, 900, and 1,000°C, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00897929
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  • 2
    Electronic Resource
    Electronic Resource
    High pressure dissociation of lactate dehydrogenase from Bacillus stearothermophilus and reconstitution of the enzyme after denaturation in 6 M guanidine hydrochloride (1984)
    Springer
    European biophysics journal 11 (1984), S. 87-94 
    Details
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Tetrameric lactate dehydrogenase from Bacillus stearothermophilus exhibits unusual stability towards high hydrostatic pressure: In contrast to the mesophilic enzyme, incubation at pressures up to 2.8 kbar does not cause irreversible denaturation. Hydridization under these conditions suggests partial dissociation to the dimer, indicating that reassociation occurs within the dead-time after pressure release (〈20 s at ≦40 μ/ml, 20° C). Incubation at P〈2.8 kbar affects neither the native quaternary structure nor the catalytic function of the enzyme. Reconstitution of the unfolded and dissociated subunits after denaturation, e.g., in 6 M guanidine ·HCl, is characterized by fast association favouring the native assembled structure. Evidence from spectroscopic measurements shows that reconstitution starts with a fast refolding reaction generating a native-like conformation. The subsequent rate-determining transconformation of the “structured monomers” governs the kinetics of reactivation and reassociation as one single first-order process. Chemical crosslinking with glutaraldehyde proves that the “structured monomers” undergo fast association to form the tetrameric final state of reconstitution, with significant amounts of dimeric intermediates being detectable. The renatured enzyme is indistinguishable from the native enzyme regarding its physicochemical and enzymological properties (e.g., activation by fructose-1,6-bisphosphate, and susceptibility towards proteolytic digestion).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276623
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  • 3
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    Philosophie in der sozialistischen Praxis (1984)
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 32:8/9 (1984) 850 
    Details
    ISSN: 0012-1045
    Topics: Philosophy
    Description / Table of Contents: BEMERKUNGEN UND BERICHTE
    Notes: Zum 35. Jahrestag der Gründung der Deutschen Demokratischen Republik und zum VI. Philosophie-Kongress der DDR
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1984-032-08-000016
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  • 4
    Electronic Resource
    Electronic Resource
    Unusual behavior of transport coefficients in aqueous solutions of zinc chloride at 25.degree.C (1984)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 88 (1984), S. 2173-2178 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150654a046
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  • 5
    Electronic Resource
    Electronic Resource
    A proton NMR study of the interactions and conformations of rationally designed brodimoprim analogs in complexes with Lactobacillus casei dihydrofolate reductase (1984)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 27 (1984), S. 1672-1676 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00378a025
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  • 6
    Electronic Resource
    Electronic Resource
    Rounding error analysis of Horner's scheme (1983)
    Springer
    Computing 30 (1983), S. 285-303 
    Details
    ISSN: 1436-5057
    Keywords: Primary 65G05 ; secondary 65F ; Horner's scheme ; rounding error analysis ; linear error equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung In dieser Arbeit entwickeln wir eine Vorwärts-Fehleranalyse für das vollständige verallgemeinerte Hornerschema eines Polynoms $$p = \sum {a_j X^{n - j} } $$ an den Stellenz 1, ...,z n . Dieser Fehleranalyse liegt die Linearisierungsmethode zugrunde, deren wesentliche Hilfsmittel Systeme linearer Fehlergleichungen und zugehöriger Konditionszahlen sind, welche optimale Schranken für die Fehler liefern, die bei Datenstörungen und dem Rechnen in Gleitkommaarithmetik entstehen können. Für das Hornerschema lassen sich diese Konditionszahlen auf einfache Weise rekursiv berechnen. Das gewöhnliche vollständige Hornerschema ist gekennzeichnet durchz=z 1=...=z n . Im Gegensatz zu den für diesen Fall bisher bekannten Fehlerabschätzungen für das Polynomp and der Stellez unterscheiden sich unsere optimalen Schranken von denen für das Polynom $$p_a = \sum {\left| {a_j } \right|X^{n - j} } $$ an der Stelle |z| und berücksichtigen so das sich teilweise Aufheben von Termen. Eine Reihe von numerischen Beispielen veranschaulicht die erhaltenen Fehlerschranken.
    Notes: Abstract In this paper we establish a forward error analysis of the generalized complete Horner scheme for a polynomial $$p = \sum {a_j X^{n - j} } $$ with pivotal pointsz 1, ...,z n . The error analysis is based on the linearization method whose fundamental tools are systems of linear error equations and associated condition numbers which yield optimal bounds of the possible errors under data perturbations and rounding errors in floating point arithmetic. For Horner's scheme the bounds may be calculated by simple recurrences. The ordinary complete Horner scheme is characterized byz=z 1=...=z n . In contrast to the hitherto known error estimates for this special case our new optimal bounds for the polynomialp atz differ from those for the polynomial $$p_a = \sum {\left| {a_j } \right|X^{n - j} } $$ at |z| and thus take into account the possible partial cancellation of terms. The error estimates are illustrated by a series of numerical examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242136
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  • 7
    Electronic Resource
    Electronic Resource
    A recurrence for Dirichlet problems (1982)
    Springer
    Computing 28 (1982), S. 65-68 
    Details
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Die formale Integration der Differential-Gl. zu einer Integral-Gl. ermöglicht die iterative Berechnung einer Klasse von kernspezifischen „Grund”-Funktionen, aus denen sich die Lösung des Randwertproblems linear aufbauen läßt.
    Notes: Abstract The formal integration of the differential eq. to an integral equation allows the iterative construction of a class of “basic” functions which, characterized by the kernel, are suitable for developing the solution to the boundary value problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02237996
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  • 8
    Electronic Resource
    Electronic Resource
    17. Der Fixateur externe - seltene Indikationen, Kombination von internen und externen Osteosynthesetechniken, Sekundäreingriffe (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 133-140 
    Details
    ISSN: 1435-2451
    Keywords: External fixation of the femur, joints, pelvis and foot ; Combination osteosynthesis ; Soft-tissue indications ; Fixateur externe am Femur, Gelenken, Becken und Fuß ; Kombinationsosteosynthesen ; Weichteilindikationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die seltenen Anwendungen der externen Stabilisierung verlangen spezielle Kenntnisse für die Indikation und die operationstechnische Montage, die wiederum eng mit den meist schwerwiegenden Knochen- und Weichteilschädigungen, den topographischen Voraussetzungen und den biomechanischen Ansprüchen verknüpft sind. Der Beitrag differenziert die Indikationsbereiche für die externe Osteosynthese am Femur, für die gelenküberbrückende Immoblisation mit dem Fixateur externe, für die instabilen Beckenringfrakturen, für Osteosynthesen und Anwendungen des Fixateur externe in der Region des Knie-, Hüft- und Handgelenkes sowie des Fußes. Weiterhin werden Kombinationen von internen und externen Osteosynthesetechniken am Femur und an der Tibia vorgestellt und diskutiert. Die Kriterien für einen Wechsel von der primären externen zur definitiven internen Osteosynthese werden ebenso wie die Osteotaxis aus reinen Weichteilgründen oder in der plastischen Chirurgie erläutert.
    Notes: Summary The rare application of external stabilisation requires special knowledge of its indications and surgical assembly, which are closely linked to usually serious bone and soft-tissue damage, topographical prerequisites and biomechanical requirements. This paper differentiates the indications for external osteosynthesis of the femur, immobilisation using external fixation to bridge a joint, unstable fractures of the pelvic girdle, osteosynthesis and application of the fixateur externe in the region of the knee, hip and hand joints, as well as the foot. Combinations of internal and external osteosynthesis techniques in the femur and tibia are presented and discussed. Criteria are discussed for changing from primary external to final internal osteosynthesis, as well as osteotaxis indicated solely by the soft tissue or in plastic surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271769
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  • 9
    Electronic Resource
    Electronic Resource
    Smoking habits and their relationship to precancerous lesions of the larynx (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 211-217 
    Details
    ISSN: 1432-1335
    Keywords: Laryngeal carcinoma ; Precancerous lesions ; Carcinoma in situ ; Cigarette smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histologic findings in vocal cord specimens of 148 male autopsy cases (ages 15–91) were compared to a retrospective anamnesis of smoking habits. The relative frequency of normal squamous epithelium is 83.3% in non-smokers, gradually decreasing from 56.3% in light to 45.8% in moderate, and finally 30.6% in heavy smokers. Ex-smokers were found to return to approximately the level of light smokers (54.2%). Precancerous lesions (dysplasia and carcinoma in situ) and carcinoma were found at lowest rates in non-smokers (4.2%) rising accordingly from 12.5% in light to 22.9% in moderate, and to 47.2% in heavy smokers, and returning to the level of light smokers (12.5%) in ex-smokers. Rates of relative frequency were rather similar, if less drastic, for hyperplastic and parakeratotic or keratinizing epithelial changes. The evaluation of lifetime tobacco consumption correlated to histologic findings in individual cases revealed an analogous pattern. Results suggest a very clear relationship between changes of vocal cord epithelia, and the quantities of tobacco consumed over a lifetime. They provide additional arguments in favor of the term “dysplasia” which, currently used to define precancerous lesions in various organs, may be suitably adopted for the morphological classification of precancerous changes of vocal cord epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405505
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  • 10
    Electronic Resource
    Electronic Resource
    Calcified cerebral necrosis following ALL therapy (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 81-91 
    Details
    ISSN: 1432-1335
    Keywords: Cerebral necrosis ; Calcification ; ALL ; Chemotherapy ; Irradiation ; Cerebrale Nekrosen ; Verkalkung ; ALL ; Chemotherapie ; Irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über ungewöhnliche cerebrale Verkalkungen nach Behandlung einer akuten lymphatischen Leukämie bei einem 13 Jahre alt gewordenen Mädchen berichtet. Im Anschluß an einen zweiten Zyklus prophylaktischer intensiver Zytostatikatherapie in Kombination mit einer zweiten Schädelbestrahlung traten Symptome einer progressiven cerebralen Schädigung auf. Pathologisch-anatomisch fanden sich bei einem ausgedehnten frischen Rezidiv einer Meningosis und Encephalosis leukämica bis 5 cm im Durchmesser große, girlandenförmige, verkalkte Nekrosen im Marklager von Groß- und Kleinhirn. In den bindegewebig abgekapselten, bevorzugt in Ventrikelnähe gelegenen Nekrosearealen waren zahlreiche fibrotisch wandverdickte Gefäße mit stenosierten und obturierten Lichtungen nachzuweisen. Die Hirnrinder war von dem Gewebsuntergang weitgehend unberührt. Neben der von anderen Autoren angenommenen lokalen Toxizität des Methotrexat als auslösender Ursache der Hirnnekrosen und einer potenzierenden Wirkung der Schädelbestrahlung erscheint uns die nachgewiesene Gefäßkomponente besonders bedeutungsvoll. Formalpathogenetisch wurde das Krankheitsbild durch die kombinierte Chemo- und Strahlentherapie bei leukämischer Gefäßwandinfiltration und partieller Gefäßverlegung durch intravasale Tumorzellthromben ausgelöst. Eine gleichzeitige Schädigung der Gefäßwände mit starker Gefäßwandfibrose und konsekutiver Ernährungsstörung führte zum umschriebenen Hirngewebsuntergang. Die bevorzugte Lokalisation im rindennahen Marklager erklärt sich aus der relativ ungünstigen Durchblutungssituation dieses Gebietes als Grenzbereich meningealer und intracerebraler Gefäße. Allein aus dem Endzustand mit multiplen verkalkten Hirngewebsnekrosen sind pathologisch-anatomisch keine sicheren Rückschlüsse auf die entscheidene Noxe —leukämische Gefäßwandinfiltrate, Chemotherapeutika, Bestrahlung — zu ziehen. Die nachgewiesenen Veränderungen sprechen aber für eine polyätiologische Genese der Hirnverkalkungen, die intravital auch computeromographisch nachweisbar sind.
    Notes: Summary Calcified cerebral necrosis was an unusual finding at the autopsy of a 13-year-old girl who died after prolonged therapy for ALL. The patient had shown symptoms of progressive cerebral damage subsequent to a second cycle of prophylactic high-dose cytostatic therapy combined with cranial irradiation. Pathoanatomic examination revealed extensive florid recurrency of meningosis and leukemic encephalosis with scalloped calcified necroses measuring up to 5 cm, in the medullar layer of brain and cerebellum. Located predominantly near the ventricular area, encapsulated necroses showed many fibrous vessels with thickened walls and stenosed or obstructed lumina. The cerebral cortex remained largely unaffected by tissue destruction. Besides methotrexate toxicity and the enhancing effect of irradiation the vascular involvement was interpreted as a particularly important factor. Formal pathogenesis is attributed to combined chemo- and radiotherapy in parallel to leukemic infiltration of vascular walls and partial obstruction of lumina by tumor emboli. Wall damage, severe fibrosis, and consecutive nutritional defects result in the destruction of cerebral tissue. The preferential occurrence of necroses in cortex-adjacent medullar layers is explained by the relatively poor blood supply of this border zone between meningeal and intracerebral vasculature. From the terminal pattern of multiple calcified necroses in cerebral tissue, no safe conclusion can be drawn pathoanatomically with regard to the actually fatal factor, whether it is the leukemic infiltration of vascular walls, the effect of cytostatic agents, or that of irradiation. The proposed multifactorial pathogenesis of cerebral calcification may be supported by computed tomography (CT) intra vitam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410537
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