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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 207-210 
    ISSN: 1432-1440
    Keywords: Activated charcoal ; Bentonite ; Fuller's earth ; Herbicides ; Paraquat ; Poisoning ; Aktivkohle ; Bentonit ; Fuller-Erde ; Herbizide ; Paraquat ; Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vitro-Untersuchungen haben ergeben, daß die Adsorptionskapazität von Aktivkohle (‘Kohle-Compretten’, ‘Ultracarbon’, E. Merck, Darmstadt, FRG), ebenso groß ist, wie diejenige von ‘Fuller's Earth’ (Surrey powder, Laporte Ind. Ltd., Luton, GB) und ‘Bentonit BP W.B.’ (Steetly Minerals Ltd., Milton Keynes, GB). ‘Fullererde’ einer anderen Firma hatte so geringe Adsorptionsfähigkeit, daß sie zur Behandlung der Paraquat-Vergiftung nicht geeignet ist. In Tierversuchen konnte gezeigt werden, daß der kurative Effekt von Aktivkohle, die 0,5, 1, 2 und 3 Stunden nach der Ingestion von 200 bzw. 300 mg Paraquat pro kg Körpergewicht verabfolgt wurde, ebenso gut oder sogar besser ist, als diejenige von ‘Fuller's Earth’ oder ‘Bentonit BP W.B.’. Aktivkohle ist ein gleichwertiger Ersatz der Mineralerden.
    Notes: Summary In vitro investigations have shown that the adsorption capacity of activated charcoal (‘Kohle-Compretten’, ‘Ultracarbon’, E. Merck, Darmstadt, FRG) is just as high as that of ‘Fuller's earth’ (Surrey powder, Laporte Industries Ltd., Luton, GB) or ‘Bentonite BP W.B.’ (Steetley Minerals Ltd., Milton Keynes, GB). Fuller's earth (‘Fullererde’) from another manufacturer has had very poor adsorption properties and is thus not suitable for the treatment of paraquat poisoning. Animal experiments have shown that the curative effect of activated charcoal given 0.5, 1, 2, and 3 h after ingestion of 200 and 300 mg paraquat/kg body weight is equally as good or even better than that of ‘Fuller's earth’ or ‘Bentonite BP W.B.’. Activated charcoal is a substitute of equal value to these mineral soils.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 765-766 
    ISSN: 1432-1440
    Keywords: Lye poisoning ; Metabolic acidosis ; Lactic acidosis ; Lauge-Intoxikation ; Metabolische Azidose ; Laktazidose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einer 38jährigen Patientin mit einer schweren peroralen Lauge-Intoxikation ohne Schock entwickelte sich trotz Substitutions-Therapie eine über 8 Tage andauernde metabolische Azidose. Die metabolische Azidose wurde durch eine Akkummulation von Milchsäure verursacht. Die gesteigerte Laktatproduktion in den Randbezirken verätzter Areale des Verdauungstrakts sowie ein gestörter hepatischer Laktatabbau sind mit großer Wahrscheinlichkeit für die Laktazidose bei Lauge-Intoxikation verantwortlich.
    Notes: Summary A woman 38 years of age suffering from severe peroral lye intoxication, without shock, developed prolonged metabolic acidosis lasting for 8 days despite substitution therapy. Metabolic acidosis was caused by lactic acid. The increased lactic acid production in the marginal regions of the corroded upper digestive tract as well as the impaired lactate removal by the injured liver were most probably responsible for this lactic acidosis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 655-659 
    ISSN: 1432-1440
    Keywords: Dermal Toxicity ; Paraquat ; Percutaneous Absorption ; Poisoning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A fatal paraquat poisoning can occur when relatively large areas of skin are contaminated with a concentrated solution of paraquat (Gramoxone). A paraquat absorption takes place of the same magnitude as that with an equal dose per os. In the presence of mechanical or chemical lesion of the skin the percutaneous paraquat absorption is distinctly enhanced.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0738
    Keywords: Clearance ; Drugs ; Hemoperfusion ; Pesticides.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An economical hemoperfusion system for clearance studies in vitro was developped. It was ascertained, that hemoperfusion using columns which contain 13 g of adsorbent and perfused at a blood flow rate of 1.25 ml/min results in the same relative clearances as when using clinical sized columns containing 300–355 g of the absorbent and run at 100 ml/min. The adsorption kinetics of toxicologically important drugs and pesticides are given as examples. To date 27 substances were tested systematically. The investigation has shown, that no adsorbent is without exception the best one, but the efficacy can vary from substance to substance.
    Type of Medium: Electronic Resource
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