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  • 1
    Electronic Resource
    Electronic Resource
    HLA, AND THE RESPONSE TO TREATMENT WITH γ-TYPE ENDORPHINS IN SCHIZOPHRENIA (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 9 (1982), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In order to investigate whether genetic factors are involved in the response of schizophrenic patients to treatment with γ-type endorphins, we typed 32 Dutch schizophrenic patients for the HLA-A, -B, -C and -DR antigens. The total patient group showed an increase of HLA-Bw4 and HLA-Cw1. A subgroup of 20 paranoid patients showed an increase of HLA-Cw1 and a significant heterogeneity for the HLA-C locus. In 16 patients who responded moderately or markedly to treatment with γ-type endorphins, an increase of HLA-B15/Cw3 and a decrease of HLA-B17 were found as compared to 16 patients with no or a slight response. Moreover, HLA-B15 was particularly increased in those patients who responded markedly and remained free of psychotic symptoms for a period of at least 6 months after treatment with γ-type endorphins (RR = 24.6, Puncorr.= 0.0015).Our results suggest that genetic factors coded for within the HLA region are associated with paranoid schizophrenia, and that HLA-B15/Cw3 is associated with a marked and prolonged response to treatment with γ-type endorphins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1982.tb00999.x
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of haloperidol on the EEG spectrum (1981)
    Springer
    Psychopharmacology 74 (1981), S. 33-34 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; EEG spectrum ; Drug classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A placebo-controlled study with six normal volunteers was carried out using 1 mg haloperidol IM. In some EEG frequency bands, the power density due to haloperidol appeared to increase or decrease depending on the subject. Nevertheless, if the results of the six subjects are taken together, the effects of haloperidol are in agreement with the literature. No correlation was found between plasma concentration of haloperidol and EEG response. Some methodological problems are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431753
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Classification of S-alleles by their activity in S-heterozygotes of brussels sprouts (Brassica oleracea var. Gemmifera (DC.) Schultz) (1982)
    Springer
    Euphytica 31 (1982), S. 603-611 
    Details
    ISSN: 1573-5060
    Keywords: Brassica oleracea var, gemmifera ; Brussels sprouts ; incompatibility ; dominance relationships of S-alleles in pollen and stigma ; S-allele activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Over a period of many years, data on dominance relationships of S-alleles in Brussels sprouts were collected at URL and IVT. The level of activity of S-alleles in heterozygotes was assessed on the basis of the number of pollen tubes that penetrated into the stigma. 209 out of 210 possible combinations between 21 S-alleles were used for this investigation. The S-alleles were grouped separately for activity in pollen and style on the basis of their sensitivity to lose activity in S-heterozygotes. Besides S-allele interaction per se, activity was found to be influenced by environment and genetic background. Results suggest that in stigma, co-dominance is the normal pattern and that deviations are caused by factors other than S-allele interaction as such. In pollen, only three truly recessive alleles were found. Besides several combinations with mutual weakening in pollen, examples of independent weakening were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00039198
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    Paper (German National Licenses)
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