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  • 1
    Electronic Resource
    Electronic Resource
    Manifestation eines Neuro-Behçet unter Cyclosporin A-Therapie (1997)
    Springer
    Zeitschrift für Rheumatologie 56 (1997), S. 31-39 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Morbus Behçet ; CSA-Therapie ; ZNS-Manifestation ; Kernspintomographie ; Chlorambucil ; Key words Morbus Behçet ; CyA-therapy ; Neuro Behçet ; MRI-imaging ; Chlorambucil therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Behçet‘s disease is a chronic inflammatory disorder characterized by the triad of oral and genital ulcers and ocular lesions. One of the most life-threatening manifestations results from involvement of the central nervous system, presenting as necrotising meningo-encephalitis, most typically affecting the brain stem, internal capsula and basal brain ganglia. We report on a young Caucasian mate with Behçet‘s disease (HLA B51+) and recurrent uveitis, who presented with acute neurologic involvement under CyA therapy 5 years after first diagnosis. At the time of admission MRI showed two high intensity lesions in the brain stem on T1 weighted images enhanced with Gd-DTPA, reflecting active inflammation. Shortly after admission the CyA treatment was stopped and a therapy with high dose steroids and chlorambucil, starting with a dose of 2mg daily was initiated. This led to improvement of neurologic symptoms, also documented by brain stem evoked potentials and investigations of cerebrospinal fluid, as well as of ophtalmologic symptoms within few days of treatment. Steroids were reduced to a maintenance dose of 12mg Prednyliden daily. The brain MRI taken 8 weeks after onset of chlorambucil treatment showed the same lesions in the brain stem, with low intensity in the T1 weighted images an no longer enhanced Gd-DTPA uptake. Chlorambucil dose was reduced to 2mg every second day after 8 months. There was no exacerbation in the follow-up of 12 months. We conclude that a 6-week Chlorambucil therapy consisting of 2mg/p.o./d led to remission of neurologic involvement firstly evolving under CyA-medication, which suggests superiority of chlorambucil as a treatment modality in neurologic as well as ophtalmologic features of the disease.
    Notes: Zusammenfassung Das Behçet-Syndrom charakterisiert das Zusammentreffen von oralen und genitalen Ulzerationen mit okulären Läsionen und gilt als vaskulitisches Geschehen. Wegen der Seltenheit des Syndroms stützen sich therapeutische Richtlinien heute noch auf kleinere Fallzahlen oder Kasuistiken. Ein beträchtliches Letalitätsrisiko bei M. Behçet stellt die ZNS-Beteiligung dar, manifest als nekrotisierende Meningo-Enzephalitis des Hirnstamms, der Capsula interna oder der Basalganglien. Im vorliegenden Fall eines jungen männlichen Patienten kaukasischer Herkunft mit seit fünf Jahren bekanntem M. Behçet (HLA B51 positiv) unter Cyclosporin A-Therapie kam es akut zu Meningismus und neurologischen Ausfällen. Die initiale Kernspintomographie zeigte im Ponsbereich Läsionen massiver KM-Anreicherung nach Gabe von Gd-DTPA als Zeichen eines akut entzündlichen Geschehens. Nach Einleitung einer Therapie mit Chlorambucil 2mg täglich p.o. kam es bei gleichzeitiger Normalisierung von Liquorbefunden, Hirnstammpotentialen und serologischen Parametern zur Remission des klinisch neurologischen Befundes, sowie der rezidivierenden okulären Symptomatik. Acht Wochen später stellten sich die Läsionen im NMR signalarm dar, ohne Anreicherung nach Kontrastmittelgabe und somit ohne Aktivität. In den folgenden 12 Monaten ergab sich unter Chlorambucil 2mg p.o. täglich bzw. jeden 2. Tag, ein stabiler Befund. Der Verlauf spricht für die Überlegenheit der Alkylantientherapie bei zentralnervösen Beteiligungen und okulären Manifestationen bei M. Behçet gegenüber der rein immunsuppressiven Behandlung mit Cyclosporin A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050018
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  • 2
    Electronic Resource
    Electronic Resource
    Dectrokardie und Poland-Syndrom bei einem 59jährigen Patienten (1997)
    Springer
    Zeitschrift für Kardiologie 86 (1997), S. 639-643 
    Details
    ISSN: 1435-1285
    Keywords: Key words Poland syndrome – dextrocardia – situs solitus ; Schlüsselwörter Poland-Syndrom – Dextrokardie – Situs solitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Poland syndrome consists of unilateral absence of the sternal head of the pectoralis major muscle, ipsilateral symbrachydaktylia, and occasionally associated other malformations of the anterior chest wall, mammilla, and mamma. To our knowledge a simultaneous occurrence with dextrocardia was reported in seven patients. We report on an additional patient with this unusual coincidence. A 59-year old man showed mild symbrachydaktylia of the left hand and deformity of the left part of the anterior chest wall, both present since birth. We found an additional dextrocardia with situs solitus, d-loop, and correctly connected great arteries. Besides arterial hypertension there was no remarkable impairment of the patient's condition.
    Notes: Zusammenfassung Das Poland-Syndrom ist gekennzeichnet durch eine einseitige Fehlbildung im Bereich der ventralen Thoraxwand mit Aplasie des sternokostalen Anteils des M. pectoralis major, eine ipsilaterale Symbrachydaktylie und gelegentlich assoziierte weitere Defekte der Thoraxwand, Mamille und Mamma. Nach unserer Kenntnis wurden bislang insgesamt sieben Fälle des gemeinsamen Auftretens einer Dextrokardie mit einem Poland-Syndrom beschrieben. Wir berichten über einen weiteren Patienten mit dieser seltenen kombinierten Fehlbildung. Bei einem 59jährigen Patienten bestanden seit Geburt eine linksseitige Thoraxdeformität sowie eine Symbrachydaktylie der linken Hand. Wir fanden bei Poland-Syndrom eine Dextrokardie bei Situs solitus, d-loop und korrekt verbundenen großen Arterien. Außer einer Hypertonie waren die Herzkreislauffunktionen nicht beeinträchtigt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050104
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  • 3
    Electronic Resource
    Electronic Resource
    Incidenz und Obduktionsfrequenz maligner Tumoren von Magen, Colon, Rectum und Lunge — 1900 bis 1975, Raum Heidelberg — (1978)
    Springer
    Virchows Archiv 380 (1978), S. 163-175 
    Details
    ISSN: 1432-2307
    Keywords: Autopsy frequency ; Selection factors ; Stomach-colon-rectum cancer ; Lung-cancer ; Incidences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for determining the incidence of malignancies of the stomach, colon, rectum, and lungs has been based on the frequency of the tumors in the autopsy material of the Institute of Pathology of the University of Heidelberg for the period 1900 to 1975. The main goal of this model is time independent selection of autopsy material indicated by an almost constant pattern for sex, average age at death, number of inhabitants, and number of autopsies. There is a relationship between incidence and autopsy frequency only when coding the diagnoses independently of their contributions to the cause of death. The results show a nearly constant incidence of stomach cancer, a steady incidence of colon and rectal cancer which, however, differs for men and women, and a large increase in the incidence of lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430623
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  • 4
    Electronic Resource
    Electronic Resource
    The regional registry of gastro-intestinal cancer North Baden (2.2 million inhabitants) (1978)
    Springer
    Virchows Archiv 380 (1978), S. 155-162 
    Details
    ISSN: 1432-2307
    Keywords: Cancer registry ; Gastro-intestinal cancer ; Histo-pathologic diagnoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Vorzüge eines bevölkerungsbezogenen patho-anatomischen Registers werden diskutiert. In einem Gebiet mit einer guten medizinischen Versorgung hat ein Organregister für Magen/Darm-Tumoren, das sich auf histologisch-pathologische Diagnosen stützt, folgenden Vorteil: Es reduziert die Stellen, an denen die Daten erhoben werden, auf einige wenige und erreicht dadurch eine sehr hohe ZuverlÄssigkeit. Als Nachteil mu\ in Kauf genommen werden, da\ die histologisch-pathologischen und die klinischen Daten in zwei verschiedenen ArbeitsgÄngen erhoben werden müssen. Die Organisation und die geographische Situation des regionalen Registers für gastro-intestinale Tumoren in Nord-Baden werden beschrieben. Die Inzidenzen der Magen/Darm-Tumoren für die Jahre 1971 und 1975 in Nord-Baden (2.2 Millionen Einwohner) werden angegeben.
    Notes: Summary The advantages of a population-based registry are discussed. It is shown that a registry for gastro-intestinal cancer in a district with expert medical care based upon histo-pathological diagnosis, has the principal advantage that it limits the sites of material collection to a few effective contributors, thus providing highly accurate data. The disadvantage of collecting data by two separate steps should be tolerated. The geographic situation and the organization of the regional registry for gastro-intestinal cancer in North Baden are described and the incidences for these cancers for the years 1971–1975 are given for the population of 2.2 million.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430622
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  • 5
    Electronic Resource
    Electronic Resource
    The incidence of gastro-intestinal cancer in North Baden (West Germany) 1971–1977 (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 301-321 
    Details
    ISSN: 1432-1335
    Keywords: Gastro-intestinal cancer ; Incidence ; Cancer registry ; Gastrointestinaler Krebs ; Inzidenzen ; Tumorregister
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde die Inzidenz bösartiger Tumoren des Ösophagus, des Magens, des Dünndarms, des Kolons und des Rektums der Jahre 1971 bis 1977 im Regierungsbezirk Nordbaden, Bundesrepublik Deutschland, bestimmt. Die Relation der Inzidenzen zu den Ernährungsgewohnheiten der Bevölkerung wird kurz diskutiert. Sowohl die Altersverteilung der Inzidenzen als auch die altersstandardisierte Inzidenz und die Geschlechterverhältnisse zeigen deutliche Unterschiede der einzelnen Tumorlokalisationen. Die Inzidenz des Kolonkrebses steigt über den betrachteten Zeitraum besonders bei Frauen stark. Auch das Risiko, an Rektumtumoren zu erkranken, hat sich in den 7 Jahren erhöht. Die Ergebnisse des auf patho-anatomischer Basis arbeitenden Registers sind mit denen klinischer Register gut vergleichbar.
    Notes: Summary The incidences of the cancer of the oesophagus, stomach, small intestines, colon, and rectum for the years 1971–1977 in the regional district of North Baden, Federal Republic of Germany are presented and their relation to environmental factors are discussed briefly. The age specific incidence as well as the age standardized incidence and the sex ratios show remarkable differences due to the specific tumor localizations. The colon cancer incidence in the female population increases steeply during the period considered. The risk of developing rectal cancer also increases. The results of the pathoanatomic registry are well comparable with the data from clinical registries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964587
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  • 6
    Electronic Resource
    Electronic Resource
    Untersuchung der Gerinnungsproteine im Brandblaseninhalt bei schweren Verbrennungen (1977)
    Springer
    Annals of hematology 35 (1977), S. 241-246 
    Details
    ISSN: 1432-0584
    Keywords: Blutgerinnungsfaktoren ; Brandblasen ; Permeabilität (Kapillardurchlässigkeit) ; Coagulation factors ; Burn blisters ; Permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Following clotting factor assays were performed on the fluid of burn blisters of 11 patients with severe burns: Fibrinogen levels, Factor II, V, X and XIII, thrombin time, fibrin split products, plasminogen, antithrombin III, IgA, IgM, IgG, ethanol gelation test and total proteins. The results showed, that a quantity of Factor II, X and XIII, antithrombin III, plasminogen and IgG had left the circulation. On the contrary we found only small concentrations of Factor V, fibrinogen, IgM and IgA in the fluid of burn blisters. This distribution suggested that the losses of plasma proteins into the burn blisters were correlated to their concentration and their molecular weight. The decrease of plasma coagulation proteins during the first days after severe burns was probably partly due to losses through the walls of the vessels, because of the increased capillary permeability.
    Notes: Zusammenfassung Bei 11 Patienten werden folgende Untersuchungen des Brandblaseninhaltes durchgeführt: Fibrinogen, F.II, F.V, F.X und F.XIII, Fibrinogen-Fibrin-Spaltprodukte, Thrombinzeit, Plasminogen, Antithrombin III, IgA, IgM, IgG, Äthanol-Test und Gesamteiweiß. Die Ergebnisse zeigen, daß nach thermischem Trauma beträchtliche Mengen der Faktoren II, X und XIII, Antithrombin III, Plasminogen und IgG das Gefäßsystem verlassen, während F.V, Fibrinogen, IgM und IgA nur im geringen Ausmaß in der Blasenflüssigkeit nachweisbar sind. Nach diesem Verteilungsmuster der Brandblasenproteine muß angenommen werden, daß ihr Austritt aus dem Intravasalraum entsprechend ihrer Plasmakonzentration und Molekülgröße erfolgt. Der Abfall von Gerinnungsfaktoren bei Verbrennungspatienten in den ersten Tagen ihrer Erkrankung läßt sich somit zum Teil durch Verluste aus dem Gefäßsystem infolge der Permeabilitätssteigerung erklären.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999465
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of fluocortolone treatment on the collagen content in guinea pig skin (1977)
    Springer
    Archives of dermatological research 257 (1977), S. 287-292 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Spezifisch pathogenfreie Meerschweinchen wurden 15 Tage lang mit verschiedenen Dosen Fluocortolon behandelt. Die behandelten Tiere zeigten die gleiche prozentuale Gewichtszunahme wie die Kontrolltiere. Der Gesamt-Hydroxyprolingehalt der Haut war in beiden Gruppen gleich, ebenso der Hydroxyprolingehalt in verschiedenen Kollagenfraktionen. Mithin scheint Fluocortolon keinen spezifischen Effekt auf die Synthese oder den Abbau von Kollagen in der Meerschweinchenhaut zu haben. Auch in der Gewichtsentwicklung der unter definierten Tierstallbedingungen gehaltenen Tiere zeigte sich kein kataboler Effekt des Fluocortolons.
    Notes: Summary Specific pathogen free guinea pigs were treated with varying dosis of fluocortolone for 15 days. The treated animals showed the same per cent weight gain as the controls. The total hydroxyproline content of the skin and the hydroxyproline content in different collagen fractions was the same in treated and untreated animals. Thus fluocortolone seems to have no specific effect on the synthesis or the breakdown of collagen in the guinea pig skin. Also the physical development of the animals, kept under defined conditions, failed to show a catabolic effect of fluorcortolone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00741845
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  • 8
    Electronic Resource
    Electronic Resource
    Animal models of autoimmune diseases (1997)
    Springer
    Rheumatology international 17 (1997), S. 91-99 
    Details
    ISSN: 1437-160X
    Keywords: Key words Autoimmune diseases ; Pathogenesis ; Animal models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Failure of distinction between self and non-self is regarded a critical event in the pathogenesis of several human diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, uveoretinitis or diabetes mellitus. Autoagressive immune reactions driven by activated autoreactive lymphocytes are a characteristic feature of these autoimmune diseases. The mechanisms by which the pathogenic control of autoreactive lymphocytes deviates from physiology can be studied in appropriate animal models under well-defined experimental conditions. Experimental models of autoimmune diseases in rodent inbred strains allow for the genetic mapping of susceptibility loci and might help to identify candidate genes also relevant to the pathogenesis of human diseases. Finally, the experimental models are valuable tools to develop rational immunotherapeutic strategies. Interesting features of some of the models employed for such research will be introduced in this review.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960050015
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  • 9
    Electronic Resource
    Electronic Resource
    The influence of local fluid flow and the microstructure on elastic and anelastic rock properties (1996)
    Springer
    Surveys in geophysics 17 (1996), S. 347-360 
    Details
    ISSN: 1573-0956
    Keywords: Ultrasonic waves ; Attenuation ; Velocity ; Microstructure ; Thermal cracking ; Local fluid flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The frequency dependent mechanism of local fluid flow was found to be the decisive absorption and dispersion mechanism in fluid containing sandstones. In the ultrasonic frequency range local fluid flow and grain surface effects control the behaviour of highly porous and highly permeable rock if a pore fluid is present. Both mechanisms depend less on macroscopic rock parameters like porosity and permeability than essentially on microscopic parameters like crack size, crack density and grain contact properties. To demonstrate directly the important influence of the microstructure on the rock elastic and anelastic properties the microstructure of a sandstone was artificially changed by thermal cracking. The cracked rock exhibits a clearly changed behaviour at low uniaxial as well as at high hydrostatic pressure despite small changes of porosity and permeability. Fluid effects increase due to cracking. The experimental results are explained by means of a rock, model and local fluid flow. These results emphasize that it is the microstructure which controls the elastic and anelastic rock behaviour, even at high hydrostatic pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01904048
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  • 10
    Electronic Resource
    Electronic Resource
    An intensity-based cooperative bidirectional stereo matching with simultaneous detection of discontinuities and occlusions (1995)
    Springer
    International journal of computer vision 15 (1995), S. 171-188 
    Details
    ISSN: 1573-1405
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper presents a new intensity-based stereo algorithm using cooperative bidirectional matching with a hierarchical multilevel structure. Based on a new model of piecewise smooth depth fields and the consistency constraint, the algorithm is able to estimate the 3-D structure and detect its discontinuities and the occlusion reliably with low computational costs. In order to find the global optimal estimates, we utilize a multiresolution two-stage algorithm minimizing nonconvex cost functions, which is equivalent to the MAP estimation. This basic framework computing the 3-D structure from binocular stereo images has been extended to the trinocular stereo vision for a further improvement of the performance. A few examples for the binocular and trinocular stereo problems are given to illustrate the performance of the new algorithms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451740
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