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  • 1
    Electronic Resource
    Electronic Resource
    Different serum soluble Fas levels in patients with allergic rhinitis and bronchial asthma (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The pathogeneses of allergic rhinitis and bronchial asthma are believed to be closely mutually related because of the similar dynamics of allergy-inducing cells and molecules and clinical overlap. In this study, we compared these diseases in the dynamics of cell apoptosis-regulating molecules. Methods: Allergic rhinitis patients (n=36), bronchial asthma patients (n=22), and healthy subjects (n=32) were subjected to measurement of serum (soluble Fas) (sFas) levels during the stable and attack disease phases by a sandwich enzyme-linked immunosorbent assay. Results: Serum sFas levels in patients with allergic rhinitis during the attack phase were significantly lower (P〈0.0001) than those in healthy individuals. There were no differences between them during the attack and stable disease phases. In contrast, serum sFas levels in patients with bronchial asthma during the attack phase were higher (P〈0.0005) than those in healthy individuals. Interestingly, the levels during the attack phase were lower (P〈0.002) than those during the stable phase. Conclusions: Our results suggest a different pathogenesis for allergic rhinitis and bronchial asthma at the cell apoptosis-linked step.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00303.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dural arteriovenous shunt involving the superior petrosal sinus: presentation and treatment by transvenous embolisation via the occipital and transverse sinuses (1997)
    Springer
    Neuroradiology 39 (1997), S. 67-70 
    Details
    ISSN: 1432-1920
    Keywords: Key words Dural arteriovenous shunt ; Superior petrosal sinus ; Endovascular treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a dural arteriovenous shunt on the superior petrosal sinus at the origin of the petrosal vein, and its treatment. This is the first report of transvenous embolisation of such a shunt through the contralateral occipital and transverse sinuses. It was possible to achieve complete obliteration of the superior petrosal sinus shunt by coils and polyvinyl acetate liquid embolisation, in a combined venous and arterial approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050369
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  • 3
    Electronic Resource
    Electronic Resource
    Cerebral blood-flow responses to induced hypotension and to CO2 inhalation in patients with major cerebral artery occlusive disease: a positron-emission tomography study (1999)
    Springer
    Neuroradiology 41 (1999), S. 73-79 
    Details
    ISSN: 1432-1920
    Keywords: Key words Cerebral blood flow ; Autoregulation ; Cerebrovascular disease ; Positron-emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our aim was to study the relationship between cerebral blood flow (CBF) responses to induced hypotension and to CO2 inhalation in patients with occlusive disease of the carotid or middle cerebral arteries. In 13 patients (8 men, 5 women) aged 31–73 years (mean ± 1 SD = 63.2 ± 10.6), regional CBF values during the resting state (CBFrest), 7 % CO2 inhalation (CBFhypercapnia), and hypotension induced by 10–20 μg/kg/min intravenous trimethaphan (CBFhypotension) were measured using positron-emission tomography (PET) with H2 15O. The % CBF change during induced hypotension (% CBFhypotension) was defined as (CBFhypotension− CBFrest)/CBFrest multiplied by 100. The % CBF change during CO2 inhalation (% CBFhypercapnia) was defined as (CBFhypercapnia− CBFrest)/CBFrest/mm Hg arterial partial pressure of CO2× 100. We defined symptomatic hemispheres as those with a stenotic or occlusive lesion with neurological symptoms or signs and asymptomatic hemispheres as those which had a similar lesion and/or were influenced by the collateral flow pattern without neurological symptoms. In the territory of the occlusive lesion, % CBFhypotension correlated significantly with % CBFhypercapnia (r = 0.793, P 〈 0.002) in the symptomatic hemispheres. In the brain regions in which trimethaphan did not induce a reduction in CBF, % CBFhypercapnia was 6.13 ± 1.79. In those in which % CBFhypotension ranged from 0 to −5, from −5 to −10, and more than −10 %, % CBFhypercapnia was 4.05 ± 1.99, 3.21 ± 1.17, and 1.73 ± 1.61, respectively, with significant differences between each pair of groups. In the asymptomatic hemispheres, % CBFhypotension also correlated with % CBFhypercapnia (r = 0.979, P 〈 0.0001). Failure to maintain CBF during induced hypotension was associated with diminished cerebrovascular vasoreactivity to hypercapnia in patients with arterial disease. This may indicate that failure of autoregulation can be assessed by the CBF response to both induced hypotension and CO2 inhalation. From the technical point of view, estimation of the CO2 response may be useful for assessing failure of autoregulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050709
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  • 4
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray crystallographic studies of 7α-hydroxysteroid dehydrogenase from Escherichia coli (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 215-217 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Crystals of 7α-hydroxysteroid dehydrogenase from E. coli, which is a tetramer in its active form, have been obtained by a hanging-drop vapor-diffusion method in the presence of the coenzyme NAD+. Crystals as large as 0.25 × 0.25 × 0.75 mm could be grown within a month at pH 8.5 with polyethylene glycol as precipitating agent. Preliminary X-ray crystallographic analysis revealed that they belong to one of the enantiomorphic space groups P41212 or P43212 with dimensions a = b = 81.66 and c = 214.6 Å, having two subunits in an asymmetric unit. The crystals diffract to at least 2.3 Å resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S090744499501002X
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  • 5
    Electronic Resource
    Electronic Resource
    Induction of cytokines, chemokines and adhesion molecule mRNA in a rat forebrain reperfusion model (1997)
    Springer
    Acta neuropathologica 93 (1997), S. 154-158 
    Details
    ISSN: 1432-0533
    Keywords: Key words Rat forebrain ; Reperfusion ; Cytokine ; Intercellular adhesion molecule-1 ; Chemokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cellular damage secondary to reperfusion following ischemic insult has been hypothetically attributed to an inflammatory cascade concerted by cell-to-cell interactions. While the role of several cytokines and adhesion molecules in reperfusion injury of the brain has been explored to a certain extent, their regulatory and temporary profiles remain unclear. We have addressed the temporal features of the induction of mRNA for proinflammatory cytokines, adhesion molecules and chemokines at an acute phase subsequent to reperfusion in rat forebrain. Semiquantitatively calibrated reverse transcription-polymerase chain reaction analysis was employed to assess the relative expression of mRNA for intercellular adhesion molecule (ICAM)-1, interleukin (IL)-1α, IL-1β, IL-2, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, monocyte-chemoattractant protein (MCP)-1, and macrophage migration inhibitory factor (MIF). The increase in mRNA from the basal levels after reperfusion followed one of two different patterns; an increase occurring as early as 1 h, or a slight increase continuing up to 24 h after reperfusion. The former pattern was seen for ICAM-1, IL-1α, IL-1β, TNF-α, and MCP-1, and the latter for IL-6 and MIF. These results were consistent with the proinflammatory properties of the immediately induced cytokines, which may be involved in the initiation step of the inflammatory cascade, causing the secondary cellular responses and finally leading to further brain damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050596
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  • 6
    Electronic Resource
    Electronic Resource
    Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1230-1240 
    Details
    ISSN: 0942-0940
    Keywords: Calcitonin gene-related peptide ; slow-release tablet ; subarachnoid haemorrhage ; cerebral vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The calcitonin gene-related peptide (CGRP), a known potent intrinsic cerebral vasodilator, is contained in the sensory nerves from trigeminal ganglia that inervate the cerebral arteries. We previously reported that human α CGRP (hCGRP) dilates spastic cerebral arteries after experimental subarachnoid haemorrhage (SAH) in rabbits. In the present study, we investigated the prophylactic potential of a sustained higher cerebrospinal fluid level ofhCGRP against experimental cerebral vasospasm. AnhCGRP slow-release tablet (hCGRP s-r tablet) was developed for cisternal implantation. Experimental SAH was induced by percutaneous cisternal injection of autologous arterial blood. Angiography was initiated on day 1 (before SAH) and performed everyday. ThehCGRP s-r tablet was implanted into the cisterna magna on day 2 in the treated groups. The spastic response of the basilar artery was maximized on day 4 in the non-treated (80.7% of day 1) and the placebo-treated (79.3%) groups. In contrast, the arterial diameters on day 4 were 96.1% and 90.5% of day 1 in the groups implanted withhCGRP 24 μg and 153 μg s-r tablets, respectively. We also measured the concentration ofhCGRP in the cerebrospinal fluid (CSF) following implantation of thehCGRP 24 μg s-r tablet in the cisterna magna. The hCGRP concentration before implantation was below the dectable level. Following implantation, thehCGRP level in the CSF was 23.12 nmol/L on the second day and remained at elevated levels until the fifth day. These experiments suggest that the intrathecal single implantation of thehCGRP s-r tablet could produce an elevated concentration ofhCGRP in the CSF over five days and have prevented the cerebral vasospasm after SAH in the rabbit. ThehCGRP s-r tablet may be clinically applicable in the treatment of patients with SAH against cerebral vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809753
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  • 7
    Electronic Resource
    Electronic Resource
    Circulating Blood Volume in Patients with Subarachnoid Haemorrhage (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 1069-1073 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Blood volume; subarachnoid haemorrhage; pulse-spectrophotometry; ICG; spasm.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  To establish the fluid management for patients with subarachnoid haemorrhage (SAH), circulating blood volume (BV) was measured by pulse-spectrophotometry using indocyanine green (ICG) in 34 cases with SAH and 20 cases with neurosurgical disorders as control. BV measured immediately after induction of anaesthesia was lower in cases with SAH than that in controls. (62.8±12.3 vs. 73.3±11.2 ml/kg, p〈0.01). In cases with SAH, the BV was significantly decreased in females (p〈0.05) but not so significantly in males. In female cases with SAH, reduced BV was increased 3 days after operation (p〈0.01). In conclusion BV is decreased in cases with SAH, especially in females. Active fluid therapy may be necessary when temporary vascular occlusion is required during aneurysm surgery. Since hypovolaemia may cause symptomatic vasospasm, BV measurement with pulse-spectrophotometry may provide useful information to insure normovolaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050484
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  • 8
    Electronic Resource
    Electronic Resource
    Intra-Operative Premature Rupture of the Cerebral Aneurysms. Analysis of the Causes and Management (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 1255-1263 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Premature rupture; cerebral aneurysm; microsurgery; temporary clipping.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The causes and management of intra-operative premature rupture are analysed and discussed.  During the past 6 years, the authors, performed 398 consecutive direct surgical interventions for ruptured cerebral aneurysms. Intra-operative premature rupture is defined as a rupture which occurs before the securing of the parent arteries or the neck of the aneurysm and is out of control, at least temporarily. The causes and management were retrospectively analysed by reviewing video tape recordings.  Intra-operative premature ruptures which met the above definition occurred in 24 cases (6.0%). The causes were as follows: 1.) dural opening and arachnoid opening (8.3%), 2.) haematoma removal (12.5%), 3.) brain retraction (16.7%), 4.) aneurysm dissection (62.5%). A double suction technique was used to control bleeding and haemostasis with a small piece of cotton or a temporary clip, performed in 20 cases (83.3%). However, in cases with premature rupture immediately after the dural or arachnoid opening, the extension of the haematoma into the subarachnoid space resulted in severe brain swelling and partial resection of the brain had to be done to secure temporary clipping. The double suction technique and primary haemostasis using a small piece of cotton or temporary clip resulted in good outcome even in cases with premature rupture. However, very early premature rupture also occurred although its incidence was extremely rare. The removal of part of the brain can secure the working space but the outcome was poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050428
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  • 9
    Electronic Resource
    Electronic Resource
    A case of giant aneurysm of the basilar artery (1979)
    Springer
    Acta neurochirurgica 49 (1979), S. 87-93 
    Details
    ISSN: 0942-0940
    Keywords: Giant aneurysm ; Basilar artery ; Agenesis of internal carotid artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a giant aneurysm, 66 mm across at its largest diameter, at the bifurcation of the basilar artery, with agenesis of the internal carotid artery, verified by angiography and autopsy, is reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809177
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  • 10
    Electronic Resource
    Electronic Resource
    The prognosis of intracranial saccular aneurysms when the surgeon refused surgery (1979)
    Springer
    Acta neurochirurgica 50 (1979), S. 259-264 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial saccular aneurysm ; conservative treatment ; follow-up study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Despite our basic policy of performing intracranial definitive surgery whenever possible in cases of intracranial saccular aneurysms, we have had 80 patients with non-radically treated aneurysms. This investigation is based on an analysis of the prognosis in 54 cases where we refused definitive surgery; it provides insight into the factors and circumstances leading to the use of treatment of secondary choice, conservative rather than definitive treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808522
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