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  • Artikel: DFG Deutsche Nationallizenzen  (11)
  • 1985-1989  (9)
  • 1975-1979  (2)
  • 1
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    Moral and Conceptual Issues in Investment and Finance: An Overview (1988)
    Dordrecht : Periodicals Archive Online (PAO)
    Journal of Business Ethics. 7:1/2 (1988:Jan.) 3 
    Details
    ISSN: 0167-4544
    Thema: Philosophie , Wirtschaftswissenschaften
    Notizen: MORAL AND CONCEPTUAL ISSUES IN INVESTMENT AND FINANCE
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:m089-1988-007-01-000002
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  • 2
    Digitale Medien
    Digitale Medien
    Pacifism as a moral ideal (1988)
    Springer
    The journal of value inquiry 22 (1988), S. 267-277 
    Details
    ISSN: 1573-0492
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Philosophie
    Notizen: Conclusion In conclusion I would like to forestall one potential misunderstanding. As I have described it the pacifist ideal may seem so difficult to attain that it may seem closed off from the aspirations of ordinary human beings; and there is no doubt that few people are likely to attain this ideal to any great degree. This accords with our intuition that “true,” by which I think we mean “paradigm” pacifists, are rare indeed. But ideals can be sought, as well as attained, to greater or lesser degrees. So there are many ordinary people who regard themselves as pacifists because they avoid violence more scrupulously than most. On my analysis their claim might well be true.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00136929
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  • 3
    Digitale Medien
    Digitale Medien
    The acute renal haemodynamic and endocrine response to felodipine in normal man (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 581-585 
    Details
    ISSN: 1432-1041
    Schlagwort(e): felodipine ; calcium antagonists ; renal haemodynamics ; prostaglandins ; kallikrein ; PGF 1 α
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Felodipine (0.075 mg/kg p.o.), a calcium antagonist, was given to 9 male volunteers, with and without indomethacin pretreatment. Diuresis and natriuresis occurred after felodipine without significant change in effective renal plasma flow or glomerular filtration rate. There was no significant change in urinary 6 keto PGF 1 α or urinary kallikrein excretion and indomethacin did not inhibit the natriuretic or diuretic response to felodipine. The felodipine induced diuresis and natriuresis appears most likely to be mediated by an action of the drug on renal tubules.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542491
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of Amiodarone and Desethylamiodarone on the Pharmacokinetics of Antipyrine in the Rat (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 251-254 
    Details
    ISSN: 1573-904X
    Schlagwort(e): amiodarone ; antipyrine ; desethylamiodarone ; drug metabolism ; drug interactions ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The effect of amiodarone on hepatic drug metabolism in vivo was examined in the rat using antipyrine as a model substrate. Pretreatment with oral amiodarone hydrochloride, 100 mg/kg/day, for 5 days resulted in a 19% reduction in antipyrine clearance and a 22% increase in half-life. The administration of single oral doses of amiodarone hydrochloride, 100 mg/kg, 1 or 5 hr prior to antipyrine administration had no significant effect on antipyrine pharmacokinetics. The administration of a single intravenous dose of amiodarone hydrochloride, 50 mg/kg, reduced antipyrine clearance by 32% and increased the half-life by 46%. The desethyl metabolite of amiodarone was also found to reduce antipyrine clearance (21%) after a single oral dose of 100 mg/kg.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1016468430618
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  • 5
    Digitale Medien
    Digitale Medien
    Moral and conceptual issues in investment and finance: An overview (1988)
    Springer
    Journal of business ethics 7 (1988), S. 3-8 
    Details
    ISSN: 1573-0697
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Philosophie , Wirtschaftswissenschaften
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00381991
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  • 6
    Digitale Medien
    Digitale Medien
    Avian scale development. Absence of an “epidermal placode” in reticulate scale morphogenesisAided by Biology Department, University of South Carolina, Columbia, South Carolina. (1977)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 154 (1977), S. 83-93 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Timed-sequence studies have shown that reticulate scales on the ventral footpads of birds do not undergo “epidermal placode” formation during their morphogenesis, but arise as symmetrical evaluations similar to the scales of snakes and lizards. Unlike the scutellate scales on the dorsal surface of the foot, in which the formation of an “epidermal placode” and its subsequent morphogenesis result in distinct outer and inner epidermal surfaces, the reticulate scales elaborate only one type of epidermal surface.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051540106
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  • 7
    Digitale Medien
    Digitale Medien
    Effect of the Immunomodulator Tilorone on the in Vivo Acetylation of Procainamide in the Rat (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 477-480 
    Details
    ISSN: 1573-904X
    Schlagwort(e): acetylation ; immunomodulators ; interferon inducers ; pharmacokinetics ; procainamide ; tilorone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Interferon and interferon inducers have been found to inhibit cytochrome P-450-dependent metabolism in animals and man. The effect of these agents on the acetylation of drugs has not been previously reported. Since these agents stimulate the reticuloendothelial system, together with the abundance of N-acetyltransferase in the reticuloendothelial system, it was hypothesized that these immunomodulators may affect drug acetylation. To test this hypothesis, the effect of tilorone (a synthetic interferon inducer) on the in vivo acetylation of procainamide was examined in the rat. Pretreatment with tilorone hydrochloride (50 mg/kg) 48 hr prior to the administration of procainamide hydrochloride (50 mg/kg) resulted in a 32% increase in the urinary recovery of N-acetylprocainamide and a 35% increase in the metabolic clearance of procainamide to N-acetylprocainamide. These data indicate that interferon inducers increase the N-acetylation of drugs in vivo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015964306318
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  • 8
    Digitale Medien
    Digitale Medien
    Effect of Hydralazine on the Elimination of Antipyrine in the Rat (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 515-518 
    Details
    ISSN: 1573-904X
    Schlagwort(e): antipyrine ; drug metabolism ; hydralazine ; hypothermia ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The concomitant administration of hydralazine with metoprolol or propranolol substantially increases the oral bioavailability of these beta-blockers, presumably via reduction of the first-pass effect. It has been suggested that this effect may be secondary to a decrease in the intrinsic clearance of propranolol, possibly by inhibition of oxidative metabolism. To examine the possibility that hydralazine alters oxidative metabolism in vivo, the effect of hydralazine on the pharmacokinetics of antipyrine was examined in the rat. The oral administration of hydralazine hydrochloride, 7.5 mg/kg, 15 min prior to antipyrine administration reduced antipyrine clearance from 9.66 ± 1.18 to 8.19 ± 0.76 ml/min/kg (P 〈 0.05). Hydralazine was observed to cause substantial hypothermia. The study was repeated in temperature-regulated animals and no alteration in antipyrine clearance was found. Two doses of hydralazine in temperature-regulated rats also failed to alter antipyrine clearance. Thus, it appears that the effect of hydralazine on antipyrine clearance is secondary to the hypothermic effect of hydralazine and not due to a direct inhibition of cytochrome P-450-mediated enzyme activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1016487824200
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  • 9
    Digitale Medien
    Digitale Medien
    Dextromethorphan Pretreatment Induces Antipyrine Clearance in the Rat (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 437-439 
    Details
    ISSN: 1573-904X
    Schlagwort(e): antipyrine ; dextromethorphan ; drug metabolism ; enzyme induction ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Numerous agents that undergo extensive first-pass metabolism have been shown to inhibit oxidative drug metabolism. To examine whether this effect is related to the chemical structure or pharmacokinetic characteristics of the inhibiting agent, we determined the effect of dextromethorphan (a compound which exhibits pharmacokinetic similarities to, but is chemically dissimilar from, previously studied agents) on the disposition of antipyrine. A single oral dose of dextromethorphan hydrobromide, 100 mg/kg, 1 hr prior to antipyrine administration had no significant effect on the pharmacokinetics of this model substrate. The administration of dextromethorphan at the same dose twice daily for 3 days and an additional dose 1 hr prior to antipyrine administration resulted in a 33% increase in the clearance of antipyrine. These data indicate that dextromethorphan is capable of inducing hepatic microsomal enzymes. Studies are needed to determine if this effect also occurs upon chronic administration in humans. These data suggest that the pharmacokinetic characteristic of extensive first-pass metabolism is not necessarily associated with inhibition of drug metabolism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015940518439
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  • 10
    Digitale Medien
    Digitale Medien
    Self-observation in natural environments: Reactive effects of behavior desirability and goal-setting (1978)
    Springer
    Cognitive therapy and research 2 (1978), S. 39-56 
    Details
    ISSN: 1573-2819
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Psychologie
    Notizen: Abstract Behavioral effects of self-monitoring in the laboratory may not prove significant when individuals self-record for extended periods in their normal environments. A series of three experiments examined the extent to which a behavior's desirability or “valence” may cause it to change when self-monitored for several days in natural settings. Subjects' time awareness, the dependent variable, was measured before and after exposure to favorable, unfavorable, or neutral evaluations of time concern; half of the subjects were also told that a specific time-awareness level or goal (performance standard)was desirable. Results disclosed limitations of previous laboratory data. Valences determined only the initial direction and magnitude of behavior change; their effect after the first posttreatment day was not uniform. A valence alone maintained significant behavior change only if the change was in a direction supported by the subject's environment. A performance standard maintained change in the face of an unfavorable environment providing the subject found the standard credible. A watchbox device permitted surreptitious reliability checks: Self-monitoring proved slightly more reliable than previous research had indicated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01172511
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