ISSN:
1432-1912
Keywords:
Tetanus
;
Toxin
;
Axonal transport
;
Autoradiography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Rats were injected i.v. with 125I-tetanus toxin. In autoradiographs of the spinal cord radioactivity was found over the pericarya and in the surroundings of the motoneurones whereas grain density was less over their nuclear region. In addition, pericarya in the lateral horn of the thoracic region and also the bipolar cells of the spinal ganglia contained radioactivity. The central part and the dorsal horns of spinal cord, and the white substance did not show any appreciable radioactivity. Within the medulla oblongata, clusters of large cells representing motor nuclei, as well as some fibre tracts close to them, contained 125I. Forebrain and cerebellum remained free. According to its histoautoradiographic appearance, generalized tetanus can be described best as a combination of multiple local tetani.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00501428
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