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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and structure of a series of thiophosphinato-bridged platinum complexes. Crystal and molecular structure of bis-.mu.-(diethylphosphido sulfide)bis(triphenyl phosphite)diplatinum (1975)
    s.l. : American Chemical Society
    Inorganic chemistry 14 (1975), S. 1121-1127 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50147a033
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential susceptibility of peripheral nerves of the hen to triorthocresyl phosphate and to trauma (1979)
    Springer
    Inflammation research 9 (1979), S. 227-231 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nerve fibres of largest diameter and of greatest length are considered to be the most vulnerable to triorthocresyl phosphate (TOCP). In this study, the differential vulnerability of the particular sciatic nerve branches was determined in the course of TOCP neuropathy and of Wallerian degeneration. The branch innervating the lateral gastrocnemius muscle, made up predominantly of large-diameter fibres, proved most susceptible to TOCP. By contrast, after proximal sciatic-nerve transection, degeneration commenced in the lateral nerve of the third digit, containing long nerve fibres of small diameter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024740
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  • 3
    Electronic Resource
    Electronic Resource
    The optimization test in the guinea-pig. A method for the predictive evaluation of the contact allergenicity of chemicals (1975)
    Springer
    Inflammation research 5 (1975), S. 174-179 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Guinea-pigs were sensitized with various substances (DNCB, penicillin G, PPL, ethylaminobenzoate, formalin) by the Draize method, the maximization method and the new optimization method (intracutaneous test employing adjuvant). The advantages of the optimization method favouring its adoption as a standard sensitization test are discussed in the light of the results obtained by this method and with the two established tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02027360
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  • 4
    Electronic Resource
    Electronic Resource
    Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 213-221 
    Details
    ISSN: 1432-0533
    Keywords: Intoxication ; Dog ; Clioquinol ; 2,5-hexanedione ; Distal axonopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The central distal axonopathy induced in dogs by the administration of high doses of clioquinol is contrasted with the central-peripheral distal axonopathy precipitated by intoxication with 2,5-hexanedione. Mature, pure-bred Beagle dogs received a daily oral dose of 400 mg/kg of clioquinol for up to 7 months, or 1 ml per animal (approximately corresponding to 110 mg/kg) of 2,5-hexanedione for up to 5 months. Intoxicated and control animals were killed and perfused at monthly intervals, so that the spatial-temporal development of the lesion could be followed and correlated with clinical symptoms. During the treatment, dogs intoxicated with 2,5-hexanedione developed symptoms of peripheral neuropathy consisting of flaccid weakness, muscle atrophy, hind-limb foot-drop and areflexia. By contrast, the dogs surviving clioquinol intoxication exhibited a stiff-legged gait, hyperreflexia but no muscle atrophy. Light and electron microscope examination of central and peripheral nervous tissue from dogs intoxicated with 2,5-hexanedione revealed giant axonal swelling and distal axonal degeneration. By contrast, dogs receiving clioquinol showed a distal axonal degeneration confined to the optic tract and the long spinal cord tracts, without any visible involvement of peripheral nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690549
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  • 5
    Electronic Resource
    Electronic Resource
    Sensory denervation of the plantar lumbrical muscle spindles in pyridoxine neuropathy (1978)
    Springer
    Acta neuropathologica 43 (1978), S. 213-216 
    Details
    ISSN: 1432-0533
    Keywords: Intrafusal muscle fibres ; Pyridoxine ; Neuropathy ; Muscle spindles ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male albino rats treated with excessive amounts of pyridoxine developed an impairment of neuromuscular function. The equatorial region of the plantar lumbrical intrafusal muscle fibres was studied in the electron microscope and the calibre of the nerve fibres was determined in semi-thin sections of the posterior tibial nerves. Degeneration of the primary sensory endings coincided with the onset of ataxia, and in more advanced stages of the neuropathy as well as after a 2-month treatment-free period the equatorial region was denervated. There was a corresponding decrease in the number of large nerve fibres. It is considered essential that primary sensory endings of lumbrical muscle spindles should be included in studies of distally accentuated sensory neuropathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691580
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  • 6
    Electronic Resource
    Electronic Resource
    Responses of single cells in cat's lateral geniculate nucleus and area 17 to the velocity of moving visual stimuli (1979)
    Springer
    Experimental brain research 34 (1979), S. 273-286 
    Details
    ISSN: 1432-1106
    Keywords: Stimulus velocity ; Single cell responses ; LGN ; Area 17 ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal responses to moving visual stimuli were recorded in the lateral geniculate nucleus (LGN) and area 17 of cats. Response duration (DE), number of spikes (NT), and mean frequency (FM) were estimated from the response histograms and analysed for their dependence on stimulus velocity. In the LGN, for about 2/3 of cells these response parameters changed monotonically with velocity up to about 100 °/s. In 1/3 of the cells, the response frequency was tuned to velocity. The speed at which individual cells reached a peak or plateau firing rate was correlated with their receptive field size. In area 17, most neurones were tuned to velocity. Nine out of 59 cells were insensitive to stimulus speed in that they responded equally well at stimulus velocities up to about 10 °/s. The results suggest that at higher levels in the nervous system information about velocity is represented in discrete groups of neurones. It is pointed out that different response parameters may be relevant for different perceptual phenomena associated with movement. The significance of integrational properties and lateral inhibition of nerve cells for the development of complex response properties is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235673
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  • 7
    Electronic Resource
    Electronic Resource
    The horizontal spread of intracortical inhibition in the visual cortex (1975)
    Springer
    Experimental brain research 22 (1975), S. 415-419 
    Details
    ISSN: 1432-1106
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234675
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  • 8
    Electronic Resource
    Electronic Resource
    Glucocorticosteroids and growth hormone secretion under physiological conditions and in states of steroid excess (1978)
    Springer
    European journal of pediatrics 128 (1978), S. 113-121 
    Details
    ISSN: 1432-1076
    Keywords: Growth hormone ; Cortisol ; Glucocorticoid therapy ; Cushing's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cortisol and growth hormone (GH) secretion (spontaneous variations at night and the release induced by insulin hypoglycaemia) were investigated in 69 children and adolescents. Statistical analysis of approximately 600 pairs of cortisol and GH values in this study demonstrated that physiological fluctuations of cortisol do not alter GH secretion. A review of the literature shows that GH secretion is consistently depressed in Cushing's disease of central origin and in Cushing's syndrome due to adrenal carcinoma. When acutely administered, doses higher than 100 mg of cortisol (or equivalent amounts of other steroids) per adult are necessary to block GH secretion and the hormones have to be given several hours previously. In long-term steroid treatment, suppression of GH is observed in only 1 out of 3 patients. The effect apparently does not persist beyond elimination of the last dose, i.e. generally not longer than 12 to 24 h. These data can be taken as a rationale for intermittent or alternating dosage schedules, and for the use of short acting derivatives if long-term, high-dose steroid treatment is necessary in children. It remains to be established whether growth deficiency in exogenous hypercortisolism is due to suppression of GH secretion, decreased production of somatomedins, direct antagonism of the action of somatomedins on growing cartilage, or a combination of these mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496996
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  • 9
    Electronic Resource
    Electronic Resource
    Predictive evaluation in animals of the contact allergenic potential of medically important substances (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 5 (1979), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Results of the optimization method and of other methods used to assess contact allergy in laboratory animals were compared with known epidemiological data on the occurrence of hypersensitivity reactions in man. Tests were performed with preservatives {formalin, ethylenediamine and sorbic acid), drugs (penicillin G, benzocaine and sulphathiazole) and other contactants belonging to widely different chemical classes (p-phenylenediamine, triclosan, pyrazole derivatives, nickel and chrome salts, eugenol, isoeugenol and mercaptobenzothiazole). The degree of sensitization achieved in guinea pigs by the optimized procedure (intradermal test with adjuvant combination) and the maximization procedure was invariably superior to that produced by the epidermal method using prior irritation of the site of application. Both the optimized procedure and the maximization test seem to be capable of identifying contact allergens that cause hypersensitivity reactions in as few as t in 10,000 of the human population as a whole. The optimization test merits consideration as a standardized and efficiently predictive procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1979.tb05528.x
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  • 10
    Electronic Resource
    Electronic Resource
    Predictive evaluation in animals of the contact allergenic potential of medically important substances I. Comparison of different methods of inducing and measuring cutaneous sensitization (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 4 (1978), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Groups of guinea pigs were sensitized with a 0.1% solution of dinitrochlorobenzene (DNCB) by the Draize intracutaneous method, The course of the induction process, the influence of the vehicles used and the extent to which the reactions are amenable to assessment according to objective criteria were examined. The sensitivity of the standardized Draize test was then compared with that of various other sensitization techniques, including:The intracutaneous test with adjuvant (optimization test)The maximization test according to Magnusson & Kligman (1969)The epidermal sensitization testThe epidermal sensitization lest wish prior irritation of the contact site (by croton oil or sodium lauryl sulphate).Comparison of these methods revealed that either the additional application of adjuvant or prior irritation of the contact site augmented the degree of sensitization to DNCR just as greatly as the simultaneous use of adjuvant and prior irritation of the skin, (maximization test.). The improved sensitization methods, and in particular the standardised optimization test, may prove to be of particular value for the study of so-called weak allergens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1978.tb03844.x
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