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  • 1
    Electronic Resource
    Electronic Resource
    Assay and characterization of serum-stimulated lipolytic activity in homogenates of human adipose tissue (1977)
    Springer
    Research in experimental medicine 170 (1977), S. 109-114 
    Details
    ISSN: 1433-8580
    Keywords: Adipose tissue ; Lipolysis ; Serum stimulation ; Lipoprotein lipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An assay of lipolytic activity in human adipose tissue is described, in which native homogenates of the adipose tissue yield the enzyme, as well as the triglyceride substrate, and the emulsifying phospholipids. The lipolytic activity in the presence of serum is characterized mainly as lipoprotein lipase activity by a pH-optimum of 8.0, by the fact that serum is necessary for full activity, and that it is inhibited by 1 M NaCl and by protamine. At serum concentrations of higher than 50% a marked inhibition of the lipolysis is observed. Noradrenaline, insulin, and heparin have no effect on the serum-stimulated lipolytic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851381
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Beziehung zwischen der Plasmakonzentration der Lipoproteide hoher Dichte (HDL) und der intravenösen Fettoleranz bei Normo- und Hypertriglyzeridämikern (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 797-800 
    Details
    ISSN: 1432-1440
    Keywords: Intravenous fat tolerance test ; High density lipoproteins ; Hypertriglyceridaemia ; Intravenöser Fettoleranztest ; High-density-lipoproteins ; Hypertriglyzeridämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 13 Normo- und 34 Hypertriglyzeridämikern wurden die Beziehungen zwischen den Plasmakonzentrationen von High-density-lipoprotein(HDL)-Cholesterin, Very-low-density(VLDL)-Triglyzeriden, Low-density-Lipoprotein(LDL)-Cholesterin und der fraktionellen Verschwinderate (K2) einer intravenös applizierten Fettemulsion (Intralipid®) untersucht. Für die Gruppe der Normal-personen und für die Gruppe der Hypertriglyzeridämiker bestand eine jeweils hochsignifikante Korrelation (p〈0,001) zwischen der Plasmakonzentration von HDL-Cholesterin und dem K2-Wert. Zwischen der Plasmakonzentration der VLDL-Triglyzeride bzw. des LDL-Cholesterins und dem K2-Wert ergaben sich für beide Gruppen keine statistisch gesicherten Beziehungen. Auf Grund dieser Befunde dürften die HDL wesentlich am Abtrasport der Plasmatriglyzeride beteiligt sein.
    Notes: Summary The relationship between the plasma concentration of high-density-lipoprotein(HDL)-cholesterol, very-low-density-lipoprotein(VLDL)-triglycerides, and low-density-lipoprotein(LDL)-cholesterol and the fractional removal rate (K2) of an intravenously administered fat emulsion (Intralipid®) was investigated in 13 normo- and 34 hypertriglyceridaemics. A highly significant correlation (p〈0,001) between the plasma concentration of HDL-cholesterol and the fractional removal rate of exogenous triglycerides was found for both groups. No significant relationship existed between the concentration of VLDL-triglycerides and of LDL-cholesterol and the removal rate of exogenous triglycerides. These observations suggest a major role of HDL in the removal of plasma triglycerides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489712
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Activation of adipose tissue lipoprotein lipase by lipoprotein fractions from normals and patients with type V hyperlipoproteinemia (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 1067-1069 
    Details
    ISSN: 1432-1440
    Keywords: Lipoproteidlipase ; Lipoproteide ; Hyperlipoproteinämie Typ V ; Lipoprotein lipase ; Lipoproteins ; Type V Hyperlipoproteinemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effects of the main lipoprotein density classes on the human adipose tissue lipoprotein lipase activity were studied. A dose-dependent stimulation of lipoprotein lipase activity was obtained for HDL and, to a lesser extent, for VLDL on a constant weight basis. LDL exerted virtually no effect. At higher concentrations, HDL as well as VLDL inhibited the stimulated lipolytic activity. In type V hyperlipoproteinemia, the stimulating effect of VLDL and of HDL was significantly lower, whereas the inhibiting action of HDL was markedly increased.
    Notes: Zusammenfassung Die Effekte der einzelnen Lipoproteidfraktionen des Plasmas auf die Aktivität der Lipoproteidlipase des menschlichen Fettgewebes wurden untersucht. HDL (high density lipoproteins) und, in geringerem Ausmaß, VLDL (very low density lipoproteins) bewirkten eine dosisabhängige Stimulierung der Aktivität der Lipoproteidlipase. LDL (low density lipoproteins) übten praktisch keinen Effekt aus. In höheren Konzentrationen hemmten sowohl HDL als auch VLDL die stimulierte lipolytische Aktivität. Bei Patienten mit Hyperlipoproteinämie Typ V war der stimulierende Effekt der VLDL und HDL viel geringer, die Hemmwirkung der HDL jedoch deutlich stärker ausgeprägt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476554
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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